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المؤلفEl-Menyar, Ayman A.
المؤلفRizk, Nasser M.
المؤلفAl-Qahtani, Awad
المؤلفAlKindi, Fahad
المؤلفElyas, Ahmed
المؤلفFarag, Fathi
المؤلفBakhsh, Fadheela Dad
المؤلفEbrahim, Samah
المؤلفAhmed, Emad
المؤلفAl-khinji, Mooza
المؤلفAl-Thani, Hassan
المؤلفAl Suwaidi, Jassim
تاريخ الإتاحة2016-11-10T11:25:29Z
تاريخ النشر2015-04
اسم المنشورJournal of Research in Medical Sciences
المعرّفhttp://www.jmsjournal.net/text.asp?2015/20/4/346/158252
الاقتباسEl-Menyar AA, Rizk NM, Al-Qahtani A, et al. The cardiovascular implication of single nucleotide polymorphisms of chromosome 9p21 locus among Arab population. Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciences. 2015;20(4):346-352.
الرقم المعياري الدولي للكتاب1735-1995
معرّف المصادر الموحدhttp://hdl.handle.net/10576/4989
الملخصBackground: Based on several reports including genome-wide association studies, genetic variability has been linked with higher (nearly half) susceptibility toward coronary artery disease (CAD). We aimed to evaluate the association of chromosome 9p21 single nucleotide polymorphisms (SNPs): rs2383207, rs10757278, and rs10757274 with the risk and severity of CAD among Arab population. Materials and Methods: A prospective observational case-control study was conducted between 2011 and 2012, in which 236 patients with CAD were recruited from the Heart Hospital in Qatar. Patients were categorized according to their coronary angiographic findings. Also, 152 healthy volunteers were studied to determine if SNPs are associated with risk of CAD. All subjects were genotyped for SNPs (rs2383207, rs2383206, rs10757274 and rs10757278) using allele-specific real-time polymerase chain reaction. Results: Patients with CAD had a mean age of 57 ± 10; of them 77% were males, 54% diabetics, and 25% had family history of CAD. All SNPs were in Hardy-Weinberg equilibrium except rs2383206, with call rate >97%. After adjusting for age, sex and body mass index, the carriers of GG genotype for rs2383207 have increased the risk of having CAD with odds ratio (OR) of 1.52 (95% confidence interval [CI] = 1.01-2.961, P = 0.046). Also, rs2383207 contributed to CAD severity with adjusted OR 1.80 (95% CI = 1.04-3.12, P = 0.035) based on the dominant genetic model. The other SNPs (rs10757274 and rs10757278) showed no significant association with the risk of CAD or its severity. Conclusion: Among Arab population in Qatar, only G allele of rs2483207 SNP is significantly associated with risk of CAD and its severity.
راعي المشروعThis study was made possible by a grant from the Qatar National Research Fund under its Undergraduate Research Experience Program# UREP (010 -030–3-070).
اللغةen
الناشرMedknow Publications
الموضوعChromosome 9p21
Coronary artery disease
Qatar
Single nucleotide polymorphisms
العنوانThe cardiovascular implication of single nucleotide polymorphisms of chromosome 9p21 locus among Arab population
النوعArticle
الصفحات346-352
رقم العدد4
رقم المجلد20
ESSN1735-7136
dc.accessType Open Access


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