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المؤلفRizk, Nasser M.
المؤلفEl-Menyar, Ayman
المؤلفEgue, Huda
المؤلفWais, Idil Souleman
المؤلفBaluli, Hissa Mohamed
المؤلفAlali, Khalid
المؤلفFarag, Fathi
المؤلفYounes, Noura
المؤلفAl Suwaidi, Jassim
تاريخ الإتاحة2016-11-14T09:52:43Z
تاريخ النشر2015
اسم المنشورBioMed Research International
المعرّفhttp://dx.doi.org/10.1155/2015/678924
الاقتباسNasser M. Rizk, Ayman El-Menyar, Huda Egue, et al., “The Association between Serum LDL Cholesterol and Genetic Variation in Chromosomal Locus 1p13.3 among Coronary Artery Disease Patients,” BioMed Research International, vol. 2015, Article ID 678924, 12 pages, 2015.
الرقم المعياري الدولي للكتاب2314-6133
معرّف المصادر الموحدhttp://hdl.handle.net/10576/4998
الملخصBackground. Several polymorphisms of a locus on chromosome 1p13.3 have a significant effect on low-density lipoprotein cholesterol (LDL-C), atherosclerosis, and acute coronary syndrome (ACS). Methods. We aimed to investigate the association between rs599839, rs646776, and rs4970834 of locus 1p13.3 and serum LDL-C and severity of coronary artery stenosis in ACS patients. Genotyping of the rs599839, rs646776, and rs4970834 polymorphisms was performed on Arab patients undergoing coronary angiography for ACS. Patients were divided into group A (ACS with insignificant stenosis (<50%)) and group B (with significant stenosis (≥50%)). Results. Patients carrying the minor G allele in rs599839 had significantly lower mean of LDL-C (2.58 versus 3.44 mM, P=0.026) than homozygous A allele carriers (GG versus AA). Carriers of minor C allele in rs64776 had significantly higher mean of HDL-C (2.16 versus 1.36 mM, P=0.004) than carriers of the T alleles (AA versus GG). The odd ratio and 95% confidence interval for dominant model for G allele carriers of rs599839 were 0.51 (0.30–0.92), P=0.038, among patients with significant stenosis. Conclusions. Polymorphisms rs646776 and rs599839 of locus 1p13.3 were significantly associated with LDL-C and other lipid parameters. In addition, the G-allele carriers of variant rs599839 had a significant protective effect against the atherosclerosis.
راعي المشروعQatar National Research Fund (a member of Qatar Foundation) under its Undergraduate Research Experience Program no. UREP: 07-091–3-020.
اللغةen
الناشرHindawi
الموضوعCholesterol, LDL/blood
Chromosomes, Human, Pair 1/genetics
Coronary Artery Disease/blood
Polymorphism, Genetic
العنوانThe Association between Serum LDL Cholesterol and Genetic Variation in Chromosomal Locus 1p13.3 among Coronary Artery Disease Patients
النوعArticle
رقم المجلد2015
ESSN2314-6141
dc.accessType Open Access


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