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AuthorRizk, Nasser M.
AuthorEl-Menyar, Ayman
AuthorEgue, Huda
AuthorWais, Idil Souleman
AuthorBaluli, Hissa Mohamed
AuthorAlali, Khalid
AuthorFarag, Fathi
AuthorYounes, Noura
AuthorAl Suwaidi, Jassim
Available date2016-11-14T09:52:43Z
Publication Date2015
Publication NameBioMed Research Internationalen_US
Identifierhttp://dx.doi.org/10.1155/2015/678924
CitationNasser M. Rizk, Ayman El-Menyar, Huda Egue, et al., “The Association between Serum LDL Cholesterol and Genetic Variation in Chromosomal Locus 1p13.3 among Coronary Artery Disease Patients,” BioMed Research International, vol. 2015, Article ID 678924, 12 pages, 2015.
ISSN2314-6133
URIhttp://hdl.handle.net/10576/4998
AbstractBackground. Several polymorphisms of a locus on chromosome 1p13.3 have a significant effect on low-density lipoprotein cholesterol (LDL-C), atherosclerosis, and acute coronary syndrome (ACS). Methods. We aimed to investigate the association between rs599839, rs646776, and rs4970834 of locus 1p13.3 and serum LDL-C and severity of coronary artery stenosis in ACS patients. Genotyping of the rs599839, rs646776, and rs4970834 polymorphisms was performed on Arab patients undergoing coronary angiography for ACS. Patients were divided into group A (ACS with insignificant stenosis (<50%)) and group B (with significant stenosis (≥50%)). Results. Patients carrying the minor G allele in rs599839 had significantly lower mean of LDL-C (2.58 versus 3.44 mM, P=0.026) than homozygous A allele carriers (GG versus AA). Carriers of minor C allele in rs64776 had significantly higher mean of HDL-C (2.16 versus 1.36 mM, P=0.004) than carriers of the T alleles (AA versus GG). The odd ratio and 95% confidence interval for dominant model for G allele carriers of rs599839 were 0.51 (0.30–0.92), P=0.038, among patients with significant stenosis. Conclusions. Polymorphisms rs646776 and rs599839 of locus 1p13.3 were significantly associated with LDL-C and other lipid parameters. In addition, the G-allele carriers of variant rs599839 had a significant protective effect against the atherosclerosis.
SponsorQatar National Research Fund (a member of Qatar Foundation) under its Undergraduate Research Experience Program no. UREP: 07-091–3-020.
Languageen
PublisherHindawi
SubjectCholesterol, LDL/blood
SubjectChromosomes, Human, Pair 1/genetics
SubjectCoronary Artery Disease/blood
SubjectPolymorphism, Genetic
TitleThe Association between Serum LDL Cholesterol and Genetic Variation in Chromosomal Locus 1p13.3 among Coronary Artery Disease Patients
TypeArticle
Volume Number2015
dc.identifier.essn 2314-6141


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