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المؤلفMashrah, Mubarak Ahmed
المؤلفFang, Ying
المؤلفSong, Wanxing
المؤلفAl-Maweri, Sadeq Ali
المؤلفLan, Yang
المؤلفLinhu, Ge
المؤلفWang, Liping
تاريخ الإتاحة2023-12-28T05:14:42Z
تاريخ النشر2023
اسم المنشورJournal of Oral Pathology and Medicine
المصدرScopus
الرقم المعياري الدولي للكتاب9042512
معرّف المصادر الموحدhttp://dx.doi.org/10.1111/jop.13480
معرّف المصادر الموحدhttp://hdl.handle.net/10576/50640
الملخصBackground: The present network meta-analysis aims to answer the question "what is the best topical intervention for the treatment of recurrent aphthous stomatitis that can provide an acceptable pain relief and promote wound healing?". Methods: From inception to October 2022, PubMed, Embase, Scopus, Cochrane Library, and China National Knowledge Infrastructure were searched to identify all potentially eligible randomized controlled trials. The primary outcomes were pain scores and/or healing time, while the secondary outcomes were the associated side effects. The Bayesian network meta-analysis accompanied by a random effect model and 95% credible intervals were calculated. Results: Forty-three randomized controlled trials with a total of 3067 participants, comparing 20 different topical medications, were included. Concerning pain reduction, the network meta-analysis failed to show any statistically significant differences when different topical treatments were compared together or even with a placebo at different time intervals. Except for doxycycline, which showed a statistically significant difference in terms of accelerating healing time, other topical interventions showed no statistically significant differences when compared with placebo or with each other. Conclusion: Within the limitations of the current network meta-analysis, it seems that: A low to moderate quality of evidence showed no superiority of any topical treatment over others concerning pain reduction, although rank probability tests revealed sucralfate, doxycycline, hyaluronic acid, and chamomile as the most efficacious treatment options at different evaluation times. Hence, further well-designed clinical trials with larger sample sizes are warranted. Topical doxycycline was shown to be the most efficacious intervention in promoting healing of recurrent aphthous stomatitis.
راعي المشروعThis study is supported by (1) the project of Guangzhou Science and Technology Bureau (202002030301), (2) the Guangdong Basic and Applied Research Fund Committee Project (2021A1515110988), and (3) the Guangdong Health Commission (A2021412).
اللغةen
الناشرJohn Wiley and Sons Inc
الموضوعaphthous ulcer
healing
pain relief
systematic review
topical treatment
العنوانTopical medications for the treatment of recurrent aphthous stomatitis: A network meta-analysis
النوعArticle Review
الصفحات811-825
رقم العدد9
رقم المجلد52
dc.accessType Abstract Only


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