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المؤلفJanket, Sok-Ja
المؤلفFraser, Douglas D
المؤلفBaird, Alison E
المؤلفTamimi, Faleh
المؤلفSohaei, Dorsa
المؤلفConte, Harry A
المؤلفPrassas, Ioannis
المؤلفDiamandis, Eleftherios P
تاريخ الإتاحة2023-12-28T05:14:42Z
تاريخ النشر2023
اسم المنشورThe Lancet Microbe
المصدرScopus
الرقم المعياري الدولي للكتاب26665247
معرّف المصادر الموحدhttp://dx.doi.org/10.1016/S2666-5247(23)00111-8
معرّف المصادر الموحدhttp://hdl.handle.net/10576/50642
الملخصThe most prevalent symptoms of post-COVID-19 condition are pulmonary dysfunction, fatigue and muscle weakness, anxiety, anosmia, dysgeusia, headaches, difficulty in concentrating, sexual dysfunction, and digestive disturbances. Hence, neurological dysfunction and autonomic impairments predominate in post-COVID-19 condition. Tachykinins including the most studied substance P are neuropeptides expressed throughout the nervous and immune systems, and contribute to many physiopathological processes in the nervous, immune, gastrointestinal, respiratory, urogenital, and dermal systems and participate in inflammation, nociception, and cell proliferation. Substance P is a key molecule in neuroimmune crosstalk; immune cells near the peripheral nerve endings can send signals to the brain with cytokines, which highlights the important role of tachykinins in neuroimmune communication. We reviewed the evidence that relates the symptoms of post-COVID-19 condition to the functions of tachykinins and propose a putative pathogenic mechanism. The antagonism of tachykinins receptors can be a potential treatment target.
اللغةen
الناشرElsevier
الموضوعTachykinins
COVID-19
pulmonary dysfunction
العنوانTachykinins and the potential causal factors for post-COVID-19 condition
النوعArticle Review
الصفحاتe642-e650
رقم العدد8
رقم المجلد4
dc.accessType Open Access


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