Mechanochemical arylative detrifluoromethylation of trifluoromethylarenes
المؤلف | Mkrtchyan, Satenik |
المؤلف | Shkoor, Mohanad |
المؤلف | Sarfaraz, Sehrish |
المؤلف | Ayub, Khurshid |
المؤلف | Iaroshenko, Viktor O. |
تاريخ الإتاحة | 2024-01-22T07:57:55Z |
تاريخ النشر | 2023-07-26 |
اسم المنشور | Organic and Biomolecular Chemistry |
المعرّف | http://dx.doi.org/10.1039/d3ob00787a |
الاقتباس | Mkrtchyan, S., Shkoor, M., Sarfaraz, S., Ayub, K., & Iaroshenko, V. O. (2023). Mechanochemical arylative detrifluoromethylation of trifluoromethylarenes. Organic & Biomolecular Chemistry, 21(32), 6549-6555. |
الرقم المعياري الدولي للكتاب | 14770520 |
الملخص | The stoichiometric defluorinative functionalization of ArCF3 is a conceptually appealing research target. It enables the challenging late-stage functionalization of CF3-containing aromatic molecules and contributes to the remedy of environmental risks resulting from the accumulation of relatively inert ArCF3-containing molecules. Similarly, Ar-CN bond features limit their utilization in cross-coupling reactions. Thus, the employment of benzonitriles in decyanative Suzuki-Miyaura type coupling remains in high demand in the field of C-C bond formation. Herein, we report mechanochemically induced and ytterbium oxide (Yb2O3)-mediated defluorinative cyanation of trifluoromethylarenes. In addition, we describe a facile mechanochemically facilitated and nickel-catalyzed decyanative arylation of benzonitriles to access biphenyls. Combining both processes in a one-pot multicomponent protocol to achieve a concise direct arylative detrifluoromethylation of ArCF3 is described herein. This work is the first hitherto realization of C-C coupling with CF3 as a formal leaving group. |
راعي المشروع | This research project was supported by a grant (Nr. APVV-21-0362) from “Agentúra na podporu výskumu a vývoja” Slovakia. |
اللغة | en |
الناشر | Royal Society of Chemistry |
الموضوع | CF3 group C-F bond activation |
النوع | Article |
الصفحات | 6549-6555 |
رقم العدد | 32 |
رقم المجلد | 21 |
ESSN | 1477-0539 |
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