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المؤلفEl Gamal, Heba
المؤلفMunusamy, Shankar
تاريخ الإتاحة2017-01-11T05:55:34Z
تاريخ النشر2017-01
المعرّفhttp://dx.doi.org/10.2174/0929866523666161128153548
الاقتباس"Aldose Reductase as a Drug Target for Treatment of Diabetic Nephropathy: Promises and Challenges", 2017, Vol. 24, numb. 1, El Gamal. Heba ,Munusamy. Shankar, Protein & Peptide Letters.
الرقم المعياري الدولي للكتاب0929-8665
معرّف المصادر الموحدhttp://hdl.handle.net/10576/5162
الملخصDiabetic nephropathy (DN) is one of the most serious microvascular complications of diabetes mellitus and the leading cause of end stage renal disease. One of the key pathways activated in DN is the polyol pathway, in which glucose is converted to sorbitol (a relatively non-metabolizable sugar) by the enzyme aldose reductase (AR). Shunting of glucose into this pathway causes disruption to glucose metabolism and subsequently damages the tissues via increased oxidative stress, protein kinase c activation and production of advanced glycation end products (AGE) in the kidney. This review aims to provide a comprehensive overview of the AR enzyme structure, substrate specificity and topology in normal physiology; to elaborate on the deleterious effects of AR activation in DN; and to summarize the potential therapeutic benefits and major challenges associated with AR inhibition in patients with DN.
راعي المشروعOffice of Academic Research, Qatar University for their support through intramural grants (# QUST-CPH-SPR-12/13-4, QUST-CPH-FALL-13/14-5, QUST-CPH- SPR-13/14-7, QUST-CPH-FALL-14/15-6, QUST-CPH-SPR-14/15-15).
اللغةen
الناشرBentham Science Publishers
الموضوعDiabetic Nephropathy
الموضوعPolyol Pathway
الموضوعProtein Kinase C
الموضوعSorbitol
الموضوعOxidative Stress
الموضوعAdvanced Glycation End products
الموضوعAldose Reductase
العنوانAldose Reductase as a Drug Target for Treatment of Diabetic Nephropathy: Promises and Challenges.
النوعArticle
الصفحات71-77
رقم العدد1
رقم المجلد24
ESSN1875-5305


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