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AuthorSampath, Chethan
AuthorRashid, Muhammed
AuthorSang, Shengmin
AuthorAhmedna, Mohamed
Available date2017-02-13T09:29:32Z
Publication Date2017-01-16
Publication NameFood Chemistryen_US
Identifierhttp://dx.doi.org/10.1016/j.foodchem.2017.01.056
CitationSampath, Chethan. Rashid, Muhammed. Sang, Shengmin. Ahmedna, Mohamed. "Specific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway", Food Chemistry, Vol. 226, pp. 79-88
ISSN0308-8146
URIhttp://hdl.handle.net/10576/5245
AbstractProlonged hyperglycemia activates the formation of advanced glycation end-products (AGEs). Major dicarbonyl compounds such as methylglyoxal or glyoxal are found to be the main precursors of AGEs and N(e)-(carboxymethyl)lysine (CML) found to be predominantly higher in the diabetic population. We hypothesized that phloretin from apple and [6]-gingerol from ginger inhibit formation of AGEs and suppress the receptor for advanced glycation end products (RAGE) via nuclear factor erythroid-2- related-factor-2 (Nrf2)-dependent pathway. Phloretin and [6]-gingerol were supplemented at two different doses to C57BL/6 mice on high fat diet or standard diet for a period of 17 weeks. Phloretin or [6]- gingerol supplementation significantly reduced plasma glucose, alanine aminotransferase, aspartate aminotransferase, AGEs and insulin levels. Phloretin and [6]-gingerol also decreased the levels of AGEs and CML levels, via Nrf2 pathway, enhancing GSH/GSSG ratio, heme oxygenase-1 and glyoxalase 1 in liver tissue. These results suggest that phloretin and [6]-gingerol are potential dietary compounds that can alleviate diabetes-induced complications.
SponsorQatar National research Fund
Languageen
PublisherElsevier
SubjectAdvance glycation end-products
SubjectPhloretin
Subject[6]-Gingerol
SubjectNrf2
SubjectRAGE
SubjectGSH
TitleSpecific bioactive compounds in ginger and apple alleviate hyperglycemia in mice with high fat diet-induced obesity via Nrf2 mediated pathway
TypeArticle
Pagination79-88
Volume Number226


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