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Tumor microenvironment: an evil nexus promoting aggressive head and neck squamous cell carcinoma and avenue for targeted therapy.
(
Springer Nature
, 2021 , Article Review)
Head and neck squamous cell carcinoma (HNSCC) is a very aggressive disease with a poor prognosis for advanced-stage tumors. Recent clinical, genomic, and cellular studies have revealed the highly heterogeneous and ...
Genetic variations influence brain changes in patients with attention-deficit hyperactivity disorder
(
Springer Nature
, 2021 , Article Review)
Attention-deficit hyperactivity disorder (ADHD) is a neurological and neurodevelopmental childhood-onset disorder characterized by a persistent pattern of inattentiveness, impulsiveness, restlessness, and hyperactivity. ...
Cytokine-chemokine network driven metastasis in esophageal cancer; promising avenue for targeted therapy
(
BMC
, 2021 , Article Review)
Esophageal cancer (EC) is a disease often marked by aggressive growth and poor prognosis. Lack of targeted therapies, resistance to chemoradiation therapy, and distant metastases among patients with advanced disease account ...
Role of NAD+ in regulating cellular and metabolic signaling pathways
(
Elsevier
, 2021 , Article Review)
BackgroundNicotinamide adenine dinucleotide (NAD+), a critical coenzyme present in every living cell, is involved in a myriad of metabolic processes associated with cellular bioenergetics. For this reason, NAD+ is often ...
miRNAs as novel immunoregulators in cancer
(
Elsevier
, 2021 , Article Review)
The immune system is a well-known vital regulator of tumor growth, and one of the main hallmarks of cancer is evading the immune system. Immune system deregulation can lead to immune surveillance evasion, sustained cancer ...
Chemokine-cytokine networks in the head and neck tumor microenvironment
(
MDPI
, 2021 , Article Review)
Head and neck squamous cell carcinomas (HNSCCs) are aggressive diseases with a dismal patient prognosis. Despite significant advances in treatment modalities, the five-year survival rate in patients with HNSCC has improved ...
Insights Into the Role of CircRNAs: Biogenesis, Characterization, Functional, and Clinical Impact in Human Malignancies
(
Frontiers Media
, 2021 , Article Review)
Circular RNAs (circRNAs) are an evolutionarily conserved novel class of non-coding endogenous RNAs (ncRNAs) found in the eukaryotic transcriptome, originally believed to be aberrant RNA splicing by-products with decreased ...
Cadmium: An Emerging Role in Adipose Tissue Dysfunction
(
Springer
, 2021 , Article Review)
Cadmium (Cd) is a toxic heavy metal that is widespread in the environment due to the substantial anthropogenic inputs from the agriculture and industrial sectors. The toxic impact of Cd adversely affects human health and ...
Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications.
(
Elsevier
, 2020 , Article Review)
The global burden of breast cancer (BC) is increasing significantly. This trend is caused by several factors such as late diagnosis, limited treatment options for certain BC subtypes, drug resistance which all lead to poor ...
RAS-mediated oncogenic signaling pathways in human malignancies
(
Elsevier
, 2018 , Article Review)
Abnormally activated RAS proteins are the main oncogenic driver that governs the functioning of major signaling
pathways involved in the initiation and development of human malignancies. Mutations in RAS genes and
or its ...