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AuthorAmir, Elhadad
AuthorMezour, Mohamed A.
AuthorAbu Nada, Lina
AuthorShurbaji, Samar
AuthorMansour, Alaa
AuthorSmith, Sophia
AuthorMoussa, Hanan
Authorlee, Lisa
AuthorPérez-Soriano, Eva M.
AuthorMurshed, Monzur
AuthorChromik, Richard
AuthorTamimi, Faleh
Available date2024-05-21T10:18:17Z
Publication Date2024-02-27
Publication NameMaterials Chemistry and Physics
Identifierhttp://dx.doi.org/10.1016/j.matchemphys.2024.129114
ISSN0254-0584
URIhttps://www.sciencedirect.com/science/article/pii/S0254058424002396
URIhttp://hdl.handle.net/10576/55239
AbstractTitanium and its alloys are essential metals for orthopedic implant manufacturing due to their exceptional mechanical properties and biocompatibility, used extensively for treating various orthopedic conditions. However, Titanium (Ti) implants have a disadvantage due to lack of bioactivity, potentially affecting osseointegration and osteoconductive capabilities, and may take several months to integrate with bone tissue. In this work, we prepared a layer of 2D magnesium phosphate (MgPi) coating on the surface of titanium surfaces via the spin-coating technique. Various techniques were used to study the phase composition of the coatings, including FTIR, Raman spectroscopy, NMR, and XRD analysis. Morphology and chemical analysis were performed using Atomic force microscopy and SEM/EDX. Nano-scratch test and water contact angle measurements were used to measure adhesion strength and wettability. In addition, in vitro cell assays were used to assess cell adhesion and viability to determine how the MC3T3-E1 osteoblast-like cells reacted to the different treated Ti substrates. AFM results showed that the surface roughness became lower after coatings. MgPi-coated samples showed higher hydrophilicity, protein adsorption, and cell viability than uncoated samples. The nano-scratch test showed that the MgPi coating showed better adherence to chemically and thermally treated samples compared to untreated samples. The deposited MgPi coating has good adhesion to the Ti-substrates. Most significantly, compared to uncoated control (Ti) (p < 0.005) and chemically treated coated samples CT-MgPi (p < 0.005), MC3T3-E1 cell proliferation was significantly increased on thermochemical coated surfaces. These findings point to resorbable two-dimensional MgPi coatings as a potential candidate for promoting Ti implant osseointegration.
SponsorThe authors would like to acknowledge Le Réseau de recherche en santé buccodentaire et osseuse (RSBO) , Canada Research Chairs (CRC) , the Natural Sciences and Engineering Research Council of Canada (NSERC) for their financial support, Qatar University , and the Libyan ministry of education and scientific research .
Languageen
SubjectTitanium
Bioactivity
Magnesium phosphate
Coatings
Protein adsorption
Title2D magnesium phosphate resorbable coating to enhance cell adhesion on titanium surfaces
TypeArticle
Volume Number316
Open Access user License http://creativecommons.org/licenses/by/4.0/
ESSN1879-3312


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