Efficacy and Safety of Lotilaner Ophthalmic Solution (0.25%) for the Treatment of Demodex Blepharitis: A GRADE Assessed Systematic Review and Meta-Analysis of Observational & Experimental Studies
المؤلف | Talha, Muhammad |
المؤلف | Haris Ali, Mohammad |
المؤلف | Fatima, Eeshal |
المؤلف | Nadeem, Arsalan |
المؤلف | Ahmed, Abdullah |
المؤلف | Nashwan, Abdulqadir J. |
تاريخ الإتاحة | 2024-08-28T04:23:42Z |
تاريخ النشر | 2024 |
اسم المنشور | American Journal of Ophthalmology |
المصدر | Scopus |
الرقم المعياري الدولي للكتاب | 29394 |
الملخص | Purpose: Several treatments have been in use for Demodex blepharitis, before the discovery of lotilaner, like tea tree oil and antibiotics; however, they either have irritable effects or systemic adverse effects, respectively. Lotilaner, a novel ectoparasiticide, has been proposed as a treatment for patients grappling with Demodex blepharitis. This review aims to assess the safety and efficacy of lotilaner in the treatment of Demodex blepharitis. Design: Systematic review and meta-analysis. Methods: An extensive search was conducted on PubMed, Cochrane Library, Scopus, and Google Scholar to find relevant literature till July 31, 2023 following the PRISMA guidelines. A total of 143 articles were retrieved by database searching, out of which 6 studies met the inclusion criteria and were included in the review. Four randomized controlled trials were included in the meta-analysis of mite eradication incidence. The review is registered with PROSPERO: CRD42023459997. Results: Lotilaner is effective in eradicating Demodex mites in individuals suffering from Demodex blepharitis according to RR for the intervention versus the control group of 3.55 (95% confidence interval [CI]: 2.87-4.40, P < .00001, I2 = 0%). The meta-analysis of clinically meaningful collarette score revealed the summary RR for the intervention versus the control group was 3.15 (95% CI: 2.56-3.89, P < 0.00001, I2 = 27%). In conclusion, the results of the included studies were comparable and consistent. Conclusions: Our results indicated that lotilaner is an effective, well-tolerated, and promising drug in treating patients with Demodex blepharitis. Lotilaner administration and cost-effectiveness should now be contemplated for the study population as these constituents have a vital impact on its treatment success. |
راعي المشروع | Funding/Support: Open Access funding is provided by the Qatar National Library. Financial Disclosures: The authors indicate no financial support or conflicts of interest. All authors attest that they meet the current ICMJE criteria for authorship. |
اللغة | en |
الناشر | Elsevier |
الموضوع | lotilaner eye drops application site pruritus blepharitis blurred vision chalazion confidence interval conjunctival hyperemia cost effectiveness analysis demodex blepharitis demodex blepharitis demodicosis demography drug efficacy drug safety eye burning eye discharge eye pain eye redness human intervention study meta analysis photophobia practice guideline prospective study randomized controlled trial (topic) Review risk assessment sample size scoring system skin irritation systematic review visual acuity animal blepharitis diagnosis drug therapy mite mite infestation observational study parasitic eye infection parasitology treatment outcome Animals Blepharitis Eye Infections, Parasitic Humans Mite Infestations Mites Observational Studies as Topic Ophthalmic Solutions Treatment Outcome |
النوع | Article Review |
الصفحات | 16-Aug |
رقم المجلد | 264 |
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