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AuthorZiyaul, Haque
AuthorTaleuzzaman, Mohamad
AuthorJamal, Ruqaiya
AuthorAl-Qahtani, Noora H.
AuthorHaque, Anzarul
Available date2024-09-11T04:59:49Z
Publication Date2024-10-15
Publication NameEuropean Journal of Pharmacology
Identifierhttp://dx.doi.org/10.1016/j.ejphar.2024.176904
ISSN00142999
URIhttps://www.sciencedirect.com/science/article/pii/S0014299924005934
URIhttp://hdl.handle.net/10576/58777
AbstractUrolithiasis, characterized by the formation of solid crystalline structures within the urinary tract, presents a significant global health burden with high recurrence rates and limited treatment efficacy. Recent research has identified various protein receptors and enzymes implicated in the pathogenesis of urolithiasis, offering potential targets for therapeutic intervention. Protein receptors such as the calcium-sensing receptor and vasopressin V2 receptor play crucial roles in regulating urinary calcium excretion and water reabsorption, respectively, influencing stone formation. Additionally, modulation of receptors like the angiotensin II receptor and aldosterone receptor can impact renal function and electrolyte balance, contributing to stone prevention. Furthermore, enzymes such as urease inhibitors and xanthine oxidase inhibitors offer targeted approaches to prevent the formation of specific stone types. This review discusses the potential of targeting these receptors and enzymes for the treatment of urolithiasis, exploring associated drugs and their mechanisms of action. Despite promising avenues for personalized and precision medicine approaches, challenges such as the need for robust clinical evidence and ensuring cost-effectiveness must be addressed for the translation of these interventions into clinical practice. By overcoming these challenges, receptor-targeted therapies and enzyme inhibitors hold promise for revolutionizing the management of urolithiasis and reducing its global burden.
SponsorThis work was supported by Qatar University through a National Capacity Building Program Grant (NCBP) [ QUCPCAM-22/24-463]. The publication of the article was financially supported by the Qatar National Library. Statements made herein are solely the responsibility of the authors.
Languageen
PublisherElsevier
SubjectUrolithiasis
Calcium-sensing receptor
Vasopressin receptor
Urease inhibitors
Xanthine oxidase inhibitors
TitleTargeting protein receptors and enzymes for precision management of urolithiasis: A comprehensive review
TypeArticle
Volume Number981
ESSN1879-0712
dc.accessType Full Text


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