College of Pharmacy: المرسلات الحديثة
السجلات المعروضة 21 -- 40 من 65
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Ethanol-Based Proliposomes Incorporating Dexamethasone for The Treatment of COVID-19 Acute Respiratory Distress Syndrome (ARDS) Using Medical Nebulizers
(2023 , Master Thesis)Background/Objective: Systemic dexamethasone has demonstrated mortality reduction in COVID-19-related acute respiratory distress syndrome (ARDS). The aim of this study is to use ethanol-based proliposome technology to ... -
Trends and Appropriateness of Sodium-glucose Co-transporter 2 Inhibitors Use in Qatar
(2023 , Master Thesis)Background: Sodium glucose co-transporter 2 inhibitors (SGLT2is) are the most recently approved class of oral antidiabetic drugs (ADDs). The objective of this study was to explore the trends in the use of SGLT2is compared ... -
HYPERTENSION MANAGEMENT AND PRESCRIBING PRACTICES IN PRIMARY HEALTHCARE SETTINGS IN QATAR: A MULTI-METHODS
(2023 , Master Thesis)Background: The use of antihypertensive medications controls blood pressure (BP) and reduces the incidence of complications. This study explored the prescribing patterns and trends of antihypertensive medications utilization, ... -
EXPLORATION OF THE APPLICATION OF PHARMACOGENETICS IN THE MANAGEMENT OF DEPRESSION
(2023 , Master Thesis)Genetic factors have been reported as playing an important role in the treatment efficacy of antidepressants (ADs). Studies report up to 55 % of patients experience AD treatment failure. The aim of this research was to ... -
IMPACT OF SGLT2 INHIBITORS ON CKD PROGRESSION IN DIABETIC PATIENTS IN QATAR A RETROSPECTIVE COHORT STUDY
(2023 , Master Thesis)Background: The risk of end-stage renal disease rises is based on the estimated glomerular filtration rate (eGFR) reduction. Even though multiple large-scale clinical trials have demonstrated the preventive benefits of ... -
SUCCINYLATED CURCUMIN LOADED IN MANNOSYLATED CHITOSAN NANOPARTICLES FOR COLON CANCER THERAPY
(06-2 , Master Thesis)Colon cancer (CRC) is the second leading cause of death and the third most diagnosed type worldwide. Although curcumin (CUR) has potent anticancer activity, it suffers from low solubility, bioavailability, and instability. ... -
THE EFFECT OF NATURAL AND SYNTHETIC COMPOUNDS ON COLORECTAL CANCER: IN VITRO AND IN VIVO STUDIES
(06-2 , Master Thesis)Colorectal cancer (CRC) is one of the deadliest malignancies in the world. Despite improved treatment, CRC incidence and mortality rates have been increasing lately. Current conventional therapies are associated with severe ... -
ANTICANCER EFFECTS OF MODIFIED CITRUS PECTIN AND CURCUMIN IN CHITOSAN NANOPARTICLES ON COLON CANCER
(06-2 , Master Thesis)We aimed to study the influence of stirring effect while modifying citrus pectin (CP), in addition to create a combination of curcumin in chitosan-modified citrus pectin (CCM-NPs) nanoparticles, along with Galectin-3 in ... -
CLINICAL AND ECONOMIC IMPACT OF GENETIC AND NON-GENETIC FACTORS ON INR NORMALIZATION IN PRE-OPERATIVE MANAGEMENT OF WARFARIN PATIENTS
(2021 , Dissertation)The aim of this Ph.D. was to evaluate the periprocedural anticoagulation management of patients receiving warfarin in Qatar clinically and economically. In addition, exploring the clinical and economic impact of genetic ... -
Cost-effectiveness Analysis of Ibuprofen versus Indomethacin or Paracetamol for the Treatment of Patent Ductus Arteriosus in Preterm Neonates
(2021 , Master Thesis)Objective: This thesis sought to evaluate the cost-effectiveness of oral paracetamol and intravenous (IV) indomethacin as alternatives to ibuprofen for patent ductus arteriosus (PDA) in neonates in Hamad Medical Corporation ... -
CLINICAL AND PHARMACOECONOMIC ANALYSES OF CDK4/6 INHIBITORS USE IN STAGE IV BREAST CANCER FEMALES IN THE STATE OF QATAR: A COMPARATIVE RETROSPECTIVE OBSERVATIONAL STUDY WITH COST-EFFECTIVENESS AND COST-UTILITY ANALYSES
(2021 , Master Thesis)Introduction: Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are indicated in the first-line treatment of hormonal receptor positive and HER-2 negative (HR+/HER2- negative) advanced breast cancer. Although phase III ... -
MOLECULAR FEATURES OF TRIPLE NEGATIVE BREAST CANCER STEM CELLS: A GENE EXPRESSION PROFILING ANALYSIS OF MDA-MB-231 CELLS
(2021 , Master Thesis)Triple negative breast cancer (TNBC) is a chemoresistant subtype of female breast tumors. Chemoresistance is attributed to the presence of long-lived cancer stem cells (CSCs) responsible for therapy failure. This study ... -
MODULATION OF THE MOLECULAR EXPRESSION AND FUNCTION OF BCL-2 FAMILY PROTEINS BY THE ARYL HYDROCARBON RECEPTOR IN BREAST CANCER STEM CELLS OF THE MDA-MB-231
(2021 , Master Thesis)Breast cancer (BC) is a frequently occurring neoplasm in women and is a second major cause of cancer related deaths. Despite the remarkable advancements in the understanding of BC and its treatments, the diseases still ... -
COMMUNITY PHARMACISTS' SELF-PERCEIVED COMPETENCY, AND ENABLERS, AND BARRIERS TOWARDS THE MANAGEMENT OF COMMON MINOR AILMENTS IN QATAR
(2021 , Master Thesis)The study aimed to assess community pharmacists' self-perceived competency, and enablers and barriers towards managing common minor ailments in Qatar, and its predictors. A cross-sectional study, with pretested questionnaires, ... -
A COST-EFFECTIVENESS ANALYSIS FOR HIGH VERSUS LOW DOSE CAFFEINE FOR THE TREATMENT OF APNEA IN NEONATAL INTENSIVE CARE UNIT
(2021 , Master Thesis)Objective: This thesis sought to evaluate the cost effectiveness of high dose (HD) caffeine as alternative therapy over the standard low dose (LD) caffeine for apnea of prematurity (AOP) in neonates, in Hamad Medical ... -
ASSESSMENT OF ADHERENCE, BARRIERS AND STRENGTHS TO ADHERENCE AMONG ADOLESCENTS WITH TYPE 1 DIABETES IN QATAR: PERSPECTIVES OF PATIENTS AND THEIR CAREGIVERS
(2021 , Master Thesis)Background: Metabolic control among adolescents with type 1 diabetes mellitus (T1DM) is generally poor. Non-adherence is one of the contributors to this poor glycemic control, leading to high complication rates. The objective ... -
Surface Coating of Carbon Nanofiber by Mesoporous Silica: a Promising Strategy to Reduce its Toxicity during Embryogenesis
(2021 , Master Thesis)Although carbon nanofibers (CNFs) have been implicated in biomedical applications, they are still considered as a potential hazard. Conversely, mesoporous silica nanoparticles are generally considered as a suitable and ... -
Exploring the Impact and Value of Collaborative Care Model in Diabetes Care at a Primary Healthcare Setting In Qatar
(2020 , Master Thesis)Background: Diabetes mellitus (DM) is one of the top health priorities in Qatar due to its high prevalence and negative health consequences. The current prevalence of DM in Qatar is 15.5%, which is projected to increase ... -
Economic Evaluation of the Cyp2c19 Genotype-Guided Antiplatelet Therapy Compared To Universal Use of Ticagrelor or Clopidogrel in Qatar
(2020 , Master Thesis)Background: Clopidogrel requires activation primarily by cytochrome P450 2C19 (CYP2C19). Patients with CYP2C19 loss-of-function alleles (LOF) are at increased risk of major adverse cardiovascular events. Ticagrelor is ... -
Strengthening the Quality of Clinical Pharmacokinetic Studies: Development and Validation of a Critical Appraisal Tool For Clinical Pharmacokinetic Research
(2020 , Master Thesis)Background: Critical appraisal process is central to the practice of evidence-based medicine that aids in assessing the quality of the published scientific knowledge. To our knowledge, there is no critical appraisal ...
