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    The gut microbiota influences blood-brain barrier permeability in mice.

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    Date
    2014-11-01
    Author
    Braniste, Viorica
    Al-Asmakh, Maha
    Kowal, Czeslawa
    Anuar, Farhana
    Abbaspour, Afrouz
    Tóth, Miklós
    Korecka, Agata
    Bakocevic, Nadja
    Ng, Lai Guan
    Guan, Ng Lai
    Kundu, Parag
    Gulyás, Balázs
    Halldin, Christer
    Hultenby, Kjell
    Nilsson, Harriet
    Hebert, Hans
    Volpe, Bruce T
    Diamond, Betty
    Pettersson, Sven
    Metadata
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    Abstract
    Pivotal to brain development and function is an intact blood-brain barrier (BBB), which acts as a gatekeeper to control the passage and exchange of molecules and nutrients between the circulatory system and the brain parenchyma. The BBB also ensures homeostasis of the central nervous system (CNS). We report that germ-free mice, beginning with intrauterine life, displayed increased BBB permeability compared to pathogen-free mice with a normal gut flora. The increased BBB permeability was maintained in germ-free mice after birth and during adulthood and was associated with reduced expression of the tight junction proteins occludin and claudin-5, which are known to regulate barrier function in endothelial tissues. Exposure of germ-free adult mice to a pathogen-free gut microbiota decreased BBB permeability and up-regulated the expression of tight junction proteins. Our results suggest that gut microbiota-BBB communication is initiated during gestation and propagated throughout life.
    DOI/handle
    http://dx.doi.org/10.1126/scitranslmed.3009759
    http://hdl.handle.net/10576/6393
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    • Health Sciences-CAS (pre 2016) [‎126 ‎ items ]

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