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AuthorAl Fahhad, Marwan. A. [مروان الفهد]
Available date2009-11-25T15:18:45Z
Publication Date2003
Publication NameQatar University Science Journal
CitationQatar University Science Journal, 2003, Vol. 23, Pages 77-86.
URIhttp://hdl.handle.net/10576/9862
AbstractSynthetic red blood cells known as LEH is a material that offers an excellent alternative to substitution blood since the chemical composition of the Oxy, LEH, is similar to that of the natural blood cells. Unfortunately, this alternative, like the natural blood, has a limited shelf life at room temperature due to thermal and/or solar (optical) radiations exposure. In this study experiments were run on LEH assays, with and without protection additives, to weigh up the effect of exposing LEH to thermal effect, using a digital controlled oven, and to optical radiations, using an appropriate apparatus to simulate the solar optical radiations. Constant evaluation of the acceptability of this artificial blood alternative was done with the help of an advanced computerized technique. The results of the experiment have shown that exposing LEH to thermal and optical radiations leads to a reduction of the concentration of the oxyhemoglobin and a heightened of the concentration of the methemoglobin. The rate of LEH degra dation in the two treatments was linked to the time in which they were exposed both to the thermal and optical radiations effects. Antioxidants, ascorbic acid and alfa-tocopherol were used in order to conserve and guard the prepared LEH from the degradation that happens to it due to the effects of both thermal and optical radiations.
Languageen
PublisherQatar University
SubjectBiological Science
بيولوجيا
TitleThermal and Optical Radiation Effects on LEH
Alternative Titleالتأثير الحرارى والضوئي على كريات الدم الحمراء المصنعة
TypeArticle
Pagination77-86
Volume Number23
Alternative Abstractتصلح كريات الدم الحمراء المصنعة المعروفة باسم ل.ا.هـ كبديل ممتاز في عمليات نقل الدم ، وهى منافس جيد لنقل الأوكسجين ، تماما كما تفعل كريات الدم الحمراء الطبيعية،. ولكن للأسف فان هذا البديل الصناعي يشبه الدم الطبيعي في قصر مدة الحياة عندما يحفظ على الرف في درجة حرارة الغرفة العادية، وذلك نظرا لتأثره بالإشعاع الحرارى والضوئي . في هذه الدراسة تم عمل تحاليل حول عمل كريات الدم الحمراء المصنعة، مع وبدون اضافات للحماية .
dc.accessType Open Access


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