Browsing by Author "Crank, Michelle C"
Now showing items 1-4 of 4
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Activation Dynamics and Immunoglobulin Evolution of Pre-existing and Newly Generated Human Memory B cell Responses to Influenza Hemagglutinin.
Andrews, Sarah F; Chambers, Michael J; Schramm, Chaim A; Plyler, Jason; Raab, Julie E; Kanekiyo, Masaru; Gillespie, Rebecca A; Ransier, Amy; Darko, Sam; Hu, Jianfei; Chen, Xuejun; Yassine, Hadi M; Boyington, Jeffrey C; Crank, Michelle C; Chen, Grace L; Coates, Emily; Mascola, John R; Douek, Daniel C; Graham, Barney S; Ledgerwood, Julie E; McDermott, Adrian B... more authors ... less authors ( Elsevier , 2019 , Article)Vaccine-induced memory B cell responses to evolving viruses like influenza A involve activation of pre-existing immunity and generation of new responses. To define the contribution of these two types of responses, we ... -
Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages.
Corbett, Kizzmekia S; Moin, Syed M; Yassine, Hadi M; Cagigi, Alberto; Kanekiyo, Masaru; Boyoglu-Barnum, Seyhan; Myers, Sky I; Tsybovsky, Yaroslav; Wheatley, Adam K; Schramm, Chaim A; Gillespie, Rebecca A; Shi, Wei; Wang, Lingshu; Zhang, Yi; Andrews, Sarah F; Joyce, M Gordon; Crank, Michelle C; Douek, Daniel C; McDermott, Adrian B; Mascola, John R; Graham, Barney S; Boyington, Jeffrey C... more authors ... less authors ( American Society for Microbiology , 2019 , Article)Influenza vaccines targeting the highly conserved stem of the hemagglutinin (HA) surface glycoprotein have the potential to protect against pandemic and drifted seasonal influenza viruses not covered by current vaccines. ... -
Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses.
Boyoglu-Barnum, Seyhan; Hutchinson, Geoffrey B; Boyington, Jeffrey C; Moin, Syed M; Gillespie, Rebecca A; Tsybovsky, Yaroslav; Stephens, Tyler; Vaile, John R; Lederhofer, Julia; Corbett, Kizzmekia S; Fisher, Brian E; Yassine, Hadi M; Andrews, Sarah F; Crank, Michelle C; McDermott, Adrian B; Mascola, John R; Graham, Barney S; Kanekiyo, Masaru... more authors ... less authors ( Nature Research , 2020 , Article)The conserved hemagglutinin (HA) stem has been a focus of universal influenza vaccine efforts. Influenza A group 1 HA stem-nanoparticles have been demonstrated to confer heterosubtypic protection in animals; however, the ... -
Use of Hemagglutinin Stem Probes Demonstrate Prevalence of Broadly Reactive Group 1 Influenza Antibodies in Human Sera.
Yassine, Hadi M; McTamney, Patrick M; Boyington, Jeffery C; Ruckwardt, Tracy J; Crank, Michelle C; Smatti, Maria K; Ledgerwood, Julie E; Graham, Barney S... more authors ... less authors ( Nature Publishing Group , 2018 , Article)A better understanding of the seroprevalence and specificity of influenza HA stem-directed broadly neutralizing antibodies (bNAbs) in the human population could significantly inform influenza vaccine design efforts. Here, ...