Browsing by Author "Althani, Asmaa"

Now showing items 1-9 of 9

    • Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA) 

      Sartelli, Massimo; Weber, Dieter; Ruppé, Etienne; Bassetti, Matteo; Wright, Brian; ... more authors ( BioMed Central , 2016 , Article)
      Intra-abdominal infections (IAI) are an important cause of morbidity and are frequently associated with poor prognosis, particularly in high-risk patients. The cornerstones in the management of complicated IAIs are timely ...

    • Common and Rare Genetic Variants Associated With Alzheimer's Disease 

      Marei, Hany E.; Althani, Asmaa; Suhonen, Jaana; El Zowalaty, Mohamed E.; Albanna, Mohammad A.; ... more authors ( WILEY PERIODICALS, INC. , 2016 , Article)
      Alzheimer's disease (AD) is one of the most devastating disorders. Despite the continuing increase of its incidence among aging populations, no effective cure has been developed mainly due to difficulties in early diagnosis ...

    • Human olfactory bulb neural stem cells (Hu-OBNSCs) can be loaded with paclitaxel and used to inhibit glioblastoma cell growth 

      Marei, Hany E.; Casalbore, Patrizia; Althani, Asmaa; Coccè, Valentina; Cenciarelli, Carlo; ... more authors ( MDPI , 2019 , Article)
      Exploitation of the potential ability of human olfactory bulb (hOB) cells to carry, release, and deliver an effective, targeted anticancer therapy within the central nervous system (CNS) milieu remains elusive. Previous ...

    • Microfluidics integrated biosensors: A leading technology towards lab-on-a-chip and sensing applications 

      Luka, George; Ahmadi, Ali; Najjaran, Homayoun; Alocilja, Evangelyn; DeRosa, Maria; ... more authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2015 , Article)
      A biosensor can be defined as a compact analytical device or unit incorporating a biological or biologically derived sensitive recognition element immobilized on a physicochemical transducer to measure one or more analytes. ...

    • Over-Expression of hNGF in Adult Human Olfactory Bulb Neural Stem Cells Promotes Cell Growth and Oligodendrocytic Differentiation 

      Marei, Hany E.; Althani, Asmaa; Afifi, Nahla; Abd-Elmaksoud, Ahmed; Bernardini, Camilla; ... more authors ( Public Library of Science ONE Staff , 2013 , Article)
      The adult human olfactory bulb neural stem/progenitor cells (OBNC/PC) are promising candidate for cell-based therapy for traumatic and neurodegenerative insults. Exogenous application of NGF was suggested as a promising ...

    • Recent Perspective About the Amyloid Cascade Hypothesis and Stem Cell-Based Therapy in the Treatment of Alzheimer's Disease 

      Marei, Hany E.; Althani, Asmaa; Suhonen, Jaana; El Zowalaty, Mohamed E.; Albanna, Mohammad A.; ... more authors ( Bentham Science , 2016 , Book chapter)
      Alzheimer's disease (AD) is a complex neurodegenerative condition that is clinically characterized by impaired cognitive functions. The major morphologically observed lesion of AD encompasses the accumulation of extracellular ...

    • Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes 

      Razali, Rozaimi Mohamad; Rodriguez-Flores, Juan; Ghorbani, Mohammadmersad; Naeem, Haroon; Aamer, Waleed; ... more authors ( Nature Research , 2021 , Article)
      Arab populations are largely understudied, notably their genetic structure and history. Here we present an in-depth analysis of 6,218 whole genomes from Qatar, revealing extensive diversity as well as genetic ancestries ...

    • Whole genome sequencing in the Middle Eastern Qatari population identifies genetic associations with 45 clinically relevant traits 

      Thareja, Gaurav; Al-Sarraj, Yasser; Belkadi, Aziz; Almotawa, Maryam; Ismail, Said; ... more authors ( Springer Nature , 2021 , Article)
      Clinical laboratory tests play a pivotal role in medical decision making, but little is known about their genetic variability between populations. We report a genome-wide association study with 45 clinically relevant traits ...

    • Willingness to participate in genome testing: a survey of public attitudes from Qatar 

      Abdul-Rahim, Hanan; Ismail, Said; Hasan, Amel; Fadl, Tasnim; Khaled, Salma; ... more authors ( Springer , 2020 , Article)
      Genomics has the potential to revolutionize medical approaches to disease prevention, diagnosis, and treatment, but it does not come without challenges. The success of a national population-based genome program, like the ...