تصفح حسب المؤلف "Alhoshani, Ali"
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6-Formylindolo(3,2-b)carbazole Dampens Inflammation and Reduces Endotoxin-Induced Kidney Injury via Nrf2 Activation
Dhulkifle, Hevna; Sayed, Tahseen S.; Abunada, Hanan H.; Abulola, Sara M.; Alhoshani, Ali; Korashy, Hesham M.; Maayah, Zaid H.... more authors ... less authors ( American Chemical Society (ACS) , 2023 , Article)Patients with sepsis are at a high risk of morbidity and mortality due to multiple organ injuries caused by pathological inflammation. Although sepsis is accompanied by multiple organ injuries, acute renal injury is a ... -
BCL-2 Inhibitor Venetoclax Induces Autophagy-Associated Cell Death, Cell Cycle Arrest, and Apoptosis in Human Breast Cancer Cells.
Alhoshani, Ali; Alatawi, Fahad O; Al-Anazi, Fawaz E; Attafi, Ibraheem M; Zeidan, Asad; Agouni, Abdelali; El Gamal, Heba M; Shamoon, Licia S; Khalaf, Sarah; Korashy, Hesham M... more authors ... less authors ( Dove Medical Press , 2020 , Article)Venetoclax (VCX) is a selective BCL-2 inhibitor approved for the treatment of leukemia and lymphoma. However, the mechanisms of anti-cancer effect of VCX either as a monotherapy or in combination with other chemotherapeutic ... -
EGFR Inhibitor Gefitinib Induces Cardiotoxicity through the Modulation of Cardiac PTEN/Akt/FoxO3a Pathway and Reactive Metabolites Formation: and Rat Studies.
Alhoshani, Ali; Alanazi, Fawaz E; Alotaibi, Moureq R; Attwa, Mohamed W; Kadi, Adnan A; Aldhfyan, Abdullah; Akhtar, Sabah; Hourani, Shireen; Agouni, Abdelali; Zeidan, Asad; Korashy, Hesham M... more authors ... less authors ( American Chemical Society , 2020 , Article)Gefitinib (GEF) is a selective inhibitor of the epidermal growth factor receptor (EGFR) used to treat non-small cell lung cancer. Yet, few cases of cardiotoxicity have been reported. However, the role of the PTEN/Akt/FoxO3a ... -
Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies
Fawaz E., Alanazi; As Sobeai, Homood M.; Alhazzani, Khalid; Al-Dhfyan, Abdullah; Alshammari, Musaad A; Alotaibi, Moureq; Al-hosaini, Khaled; Korashy, Hesham M.; Alhoshani, Ali... more authors ... less authors ( Elsevier , 2021 , Article)Melanoma is an aggressive skin cancer with a high rate of metastasis to other organs. Recent studies specified the overexpression of V-domain Ig suppressor of T-cell activation (VISTA) and Aryl Hydrocarbon Receptor (AHR) ...