Browsing by Author "Yousaf, Sakib"
Now showing items 1-9 of 9
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Design characteristics of inhaler devices used for pulmonary delivery of medical aerosols
Khan, Iftikhar; Yousaf, Sakib; Alhnan, Mohamed Albed; Ahmed, Waqar; Elhissi, Abdelbary; Jackson, Mark J.... more authors ... less authors ( Springer International Publishing , 2016 , Book chapter)For the treatment of respiratory diseases, it is vital to deliver therapeutic doses of drugs to specific regions in the tracheobronchial tree (TBT) of the lung with maximal efficiency and minimal wastage of medication. ... -
Fabrication, characterization and optimization of nanostructured lipid carrier formulations using Beclomethasone dipropionate for pulmonary drug delivery via medical nebulizers
Khan, Iftikhar; Hussein, Sozan; Houacine, Chahinez; Khan Sadozai, Sajid; Islam, Yamir; Bnyan, Ruba; Elhissi, Abdelbary; Yousaf, Sakib... more authors ... less authors ( Elsevier , 2021 , Article)Aerosolization is a non-invasive approach in drug delivery for localized and systemic effect. Nanostructured lipid carriers (NLCs) are new generation versatile carriers, which offer protection from degradation and enhance ... -
A Facile and Novel Approach to Manufacture Paclitaxel-Loaded Proliposome Tablet Formulations of Micro or Nano Vesicles for Nebulization
Khan, Iftikhar; Lau, Katie; Bnyan, Ruba; Houacine, Chahinez; Roberts, Matthew; Isreb, Abdullah; Elhissi, Abdelbary; Yousaf, Sakib... more authors ... less authors ( Springer , 2020 , Article)© 2020, The Author(s). Purpose: The aim of this study was to develop novel paclitaxel-loaded proliposome tablet formulations for pulmonary drug delivery. Method: Proliposome powder formulations (i.e. F1 – F27) were prepared ... -
Impact of dispersion media and carrier type on spray-dried proliposome powder formulations loaded with beclomethasone dipropionate for their pulmonary drug delivery via a next generation impactor
Khan, Iftikhar; Al-Hasani, Ali; Khan, Mohsin H.; Khan, Aamir N.; -Alam, Fakhr-e; Sadozai, Sajid K.; Elhissi, Abdelbary; Khan, Jehanzeb; Yousaf, Sakib... more authors ... less authors ( Public Library of Science , 2023 , Article)Drug delivery via aerosolization for localized and systemic effect is a non-invasive approach to achieving pulmonary targeting. The aim of this study was to prepare spray-dried proliposome (SDP) powder formulations to ... -
Impact of phospholipids, surfactants and cholesterol selection on the performance of transfersomes vesicles using medical nebulizers for pulmonary drug delivery
Iftikhar, Khan; Needham, Rachel; Yousaf, Sakib; Houacine, Chahinez; Islam, Yamir; Bnyan, Ruba; Sadozai, Sajid Khan; Elrayess, Mohamed A.; Elhissi, Abdelbary... more authors ... less authors ( Elsevier , 2021 , Article)The aim of this study is to formulate and optimize novel transfersome formulations for pulmonary drug delivery. Transfersome formulations (F1 – F18) were prepared by a thin-film method using three phospholipids (Soya ... -
Paclitaxel-loaded micro or nano transfersome formulation into novel tablets for pulmonary drug delivery via nebulization
Iftikhar, Khan; Apostolou, Maria; Bnyan, Ruba; Houacine, Chahinez; Elhissi, Abdelbary; Yousaf, Sakib S... more authors ... less authors ( Elsevier , 2020 , Article)A simplistic approach was adopted to manufacture novel paclitaxel (PTX) loaded protransfersome tablet formulations for pulmonary drug delivery. The large surface area offered by the pulmonary system acts as a desirable ... -
Proliposome powder or tablets for generating inhalable liposomes using a medical nebulizer
Khan, Iftikhar; Yousaf, Sakib; Najlah, Mohammad; Ahmed, Waqar; Elhissi, Abdelbary ( Springer , 2021 , Article)© 2020, The Author(s). Purpose: The aim of this study was to develop and compare proliposome powder and proliposome tablet formulations for drug delivery from a Pari-LC Sprint nebulizer. Methods: Proliposome powders were ... -
Proliposome Powders for the Generation of Liposomes: the Influence of Carbohydrate Carrier and Separation Conditions on Crystallinity and Entrapment of a Model Antiasthma Steroid
Khan, Iftikhar; Yousaf, Sakib; Subramanian, Sneha; Alhnan, Mohamed AlbedAhmed, Waqar; Elhissi, Abdelbary ( Springer New York LLC , 2018 , Article)Formulation effects on the entrapment of beclometasone dipropionate (BDP) in liposomes generated by hydration of proliposomes were studied, using the high-density dispersion medium deuterium oxide in comparison to deionized ... -
Proliposome powders prepared using a slurry method for the generation of beclometasone dipropionate liposomes
Khan, Iftikhar; Yousaf, Sakib; Subramanian, Sneha; Korale, Oshadie; Alhnan, Mohamed Albed; Ahmed, Waqar; Taylor, Kevin M.G.; Elhissi, Abdelbary... more authors ... less authors ( Elsevier , 2015 , Article)A novel “slurry method” was described for the preparation of proliposome powders using soya phosphatidylcholine (SPC) with cholesterol (1:1) and for incorporation of beclometasone dipropionate (BDP) at 2mole% of the total ...