تصفح حسب المؤلف "Agrelli, Almerinda"
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Brief Report: Polymorphisms in TNF-α/TNFR1 Pathway Genes Are Associated With CD4+ T-Cell Recovery in HIV-1–Infected Individuals on Antiretroviral Therapy
Celerino da Silva, Ronaldo; Alves, Neyla M. Pereira; Gondim Silva, Maria L.; Agrelli, Almerinda; Coelho, Antonio V. Campos; Guimarães, Rafael L.; Arraes, Luiz C.; Crovella, Sergio; Brandão, Lucas A. Cavalcanti... more authors ... less authors ( NLM (Medline) , 2021 , Article)Background: Antiretroviral therapy (ART) is an important hallmark of HIV-1 treatment, enabling viral load suppression to undetectable levels and CD4+ T-cell recovery. However, some individuals do not recover the CD4+ ... -
Different molecular pathways are disrupted in Pyoderma gangrenosum patients and are associated with the severity of the disease.
Moura, Ronald Rodrigues; Brandão, Lucas; Moltrasio, Chiara; Agrelli, Almerinda; Tricarico, Paola Maura; Maronese, Carlo Alberto; Crovella, Sergio; Marzano, Angelo Valerio... more authors ... less authors ( Nature Research , 2023 , Article)Pyoderma gangrenosum (PG) is a rare inflammatory skin disease classified within the spectrum of neutrophilic dermatoses. The pathophysiology of PG is yet incompletely understood but a prominent role of genetics facilitating ... -
In silico analysis of molecular interactions between HIV-1 glycoprotein gp120 and TNF receptors
Neyla Maria Pereira, Alves; de Moura, Ronald Rodrigues; Bernardo, Lucas Coêlho; Agrelli, Almerinda; de Oliveira, Ana Sofia Lima Estevão; da Silva, Natália Pereira; Crovella, Sergio; Brandão, Lucas André Cavalcanti... more authors ... less authors ( Elsevier , 2021 , Article)Proinflammatory microenvironmental is crucial for the Human Immunodeficiency Virus Type 1 (HIV-1) pathogenesis. The viral glycoprotein 120 (gp120) must interact with the CD4+ T cell chemokine receptor (CCR5) and a co-receptor ... -
A loss-of-function NCSTN mutation associated with familial Dowling Degos disease and hidradenitis suppurativa
de Oliveira, Ana Sofia Lima Estevao; de Siqueira, Roberta Cardoso; Nait-Meddour, Cécile; Tricarico, Paola Maura; Moura, Ronald; Agrelli, Almerinda; d'Adamo, Adamo Pio; Jamain, Stéphane; Crovella, Sergio; de Fátima Medeiros Brito, Maria; Boniotto, Michele; Brandão, Lucas André Cavalcanti... more authors ... less authors ( Wiley , 2023 , Article)Dowling Degos disease (DDD) is a rare autosomal dominant genodermatosis characterized by acquired, slowly progressive reticulated pigmented lesions primarily involving flexural skin areas. Mutations in KRT5, POGLUT-1 and ... -
Multiomics integration in skin diseases with alterations in notch signaling pathway: PlatOMICs phase 1 deployment
Brandão, Lucas André Cavalcanti; Tricarico, Paola Maura; Gratton, Rossella; Agrelli, Almerinda; Zupin, Luisa; Abou-Saleh, Haissam; Moura, Ronald; Crovella, Sergio... more authors ... less authors ( MDPI , 2021 , Article Review)The high volume of information produced in the age of omics was and still is an important step to understanding several pathological processes, providing the enlightenment of complex molecular networks and the identification ... -
An overview of Zika virus genotypes and their infectivity
Bernardo-Menezes, Lucas Coêlho; Agrelli, Almerinda; de Oliveira, Ana Sofia Lima Estevão; de Moura, Ronald Rodrigues; Crovella, Sergio; Brandão, Lucas André Cavalcanti... more authors ... less authors ( Sociedade Brasileira de Medicina Tropical , 2022 , Article Review)Zika virus (ZIKV) is an enveloped, single-stranded RNA arbovirus belonging to the genus Flavivirus. It was first isolated from a sentinel monkey in Uganda in 1947. More recently, ZIKV has undergone rapid geographic expansion ... -
Transcriptome Meta-Analysis Confirms the Hidradenitis Suppurativa Pathogenic Triad: Upregulated Inflammation, Altered Epithelial Organization, and Dysregulated Metabolic Signaling
de Oliveira, Ana Sofia Lima Estevao; Bloise, Giovanna; Moltrasio, Chiara; Coelho, Antonio; Agrelli, Almerinda; Moura, Ronald; Tricarico, Paola Maura; Jamain, Stéphane; Marzano, Angelo Valerio; Crovella, Sergio; Cavalcanti Brandão, Lucas André... more authors ... less authors ( MDPI , 2022 , Article)Hidradenitis suppurativa (HS) is an inflammatory skin condition clinically characterized by recurrent painful deep-seated nodules, abscesses, and sinus tracks in areas bearing apocrine glands, such as axillae, breasts, ...