تصفح حسب المؤلف "Iratni, Rabah"
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Role of RhoA and Rho-associated kinase in phenotypic switching of vascular smooth muscle cells: Implications for vascular function
Tedy, Sawma; Shaito, Abdullah; Najm, Nicolas; Sidani, Munir; Orekhov, Alexander; El-Yazbi, Ahmed F.; Iratni, Rabah; Eid, Ali H.... more authors ... less authors ( Elsevier , 2022 , Article Review)Cardiovascular disease (CVD) continues to be the primary cause of global mortality. Vascular smooth muscle cells (VSMCs) are integral components of vascular structure and function, evident by their vital roles in modulating ... -
Salinomycin induces apoptosis and senescence in breast cancer: Upregulation of p21, downregulation of survivin and histone H3 and H4 hyperacetylation
Al Dhaheri, Yusra; Attoub, Samir; Arafat, Kholoud; AbuQamar, Synan; Eid, Ali; Al Faresi, Nesreen; Iratni, Rabah... more authors ... less authors ( Elsevier , 2013 , Article)Background In the present study, we investigated the effect of Salinomycin on the survival of three human breast cancer cell lines MCF-7, T47D and MDA-MB-231 grown in adherent culture conditions. Methods Cell viability ... -
Salvia fruticosa Induces Vasorelaxation in Rat Isolated Thoracic Aorta: Role of the PI3K/Akt/eNOS/NO/cGMP Signaling Pathway
Anwar, M. Akhtar; Samaha, Ali A.; Ballan, Samar; Saleh, Alaaeldin I.; Iratni, Rabah; Eid, Ali H.... more authors ... less authors ( Nature Publishing Group , 2017 , Article)Salvia fruticosa (SF) Mill. is traditionally used for its antihypertensive actions. However, little is known about its pharmacologic and molecular mechanisms of action. Here we determined the effects of an ethanolic extract ... -
The SARS-CoV-2 Spike Protein Activates the Epidermal Growth Factor Receptor-Mediated Signaling
Palakkott, Abdul Rasheed; Alneyadi, Aysha; Muhammad, Khalid; Eid, Ali Hussein; Amiri, Khaled M.A.; Akli Ayoub, Mohammed; Iratni, Rabah... more authors ... less authors ( MDPI , 2023 , Article)The coronavirus disease-19 (COVID-19) pandemic is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At the molecular and cellular levels, the SARS-CoV-2 uses its envelope glycoprotein, the ... -
Synthesis of New Chromene Derivatives Targeting Triple-Negative Breast Cancer Cells
Alneyadi, Aysha; Nizami, Zohra N.; Aburawi, Hanan E.; Hisaindee, Soleiman; Nawaz, Muhammad; Attoub, Samir; Ramadan, Gaber; Benhalilou, Nehla; Al Azzani, Mazoun; Elmahi, Yassine; Almeqbali, Aysha; Muhammad, Khalid; Eid, Ali H.; Vijayan, Ranjit; Iratni, Rabah... more authors ... less authors ( MDPI , 2023 , Article)Breast cancer continues to be the leading cause of cancer-related deaths among women worldwide. The most aggressive type of breast cancer is triple-negative breast cancer (TNBC). Indeed, not only does TNBC not respond well ... -
Therapeutic potential of flavonoids in cancer: ROS-mediated mechanisms
Hasan, Slika; Mansour, Hadi; Wehbe, Nadine; Nasser, Suzanne A.; Iratni, Rabah; Nasrallah, Gheyath; Shaito, Abdullah; Ghaddar, Tarek; Kobeissy, Firas; Eid, Ali H.... more authors ... less authors ( Elsevier , 2022 , Article)Cancer is a leading cause of morbidity and mortality around the globe. Reactive oxygen species (ROS) play contradicting roles in cancer incidence and progression. Antioxidants have attracted attention as emerging therapeutic ... -
Visfatin : An emerging adipocytokine bridging the gap in the evolution of cardiovascular diseases
Dakroub, Ali; Nasser, Suzanne A; Kobeissy, Firas; Yassine, Hadi M; Orekhov, Alexander; Sharifi-Rad, Javad; Iratni, Rabah; El-Yazbi, Ahmed F; Eid, Ali H... more authors ... less authors ( Wiley , 2021 , Article)Visfatin/nicotinamide phosphoribosyltransferase (NAMPT) is an adipokine expressed predominately in visceral fat tissues. High circulating levels of visfatin/NAMPT have been implicated in vascular remodeling, vascular ... -
Ziziphus nummularia attenuates the malignant phenotype of human pancreatic cancer cells: Role of ros
Mesmar, J.; Mesmar, Joelle; Fardoun, Manal M.; Abdallah, Rola; Al Dhaheri, Yusra; Yassine, Hadi M.; Iratni, Rabah; Badran, Adnan; Eid, Ali H.; Baydoun, Elias... more authors ... less authors ( MDPI AG , 2021 , Article)Pancreatic cancer (PC) is the fourth leading cause of all cancer-related deaths. Despite major improvements in treating PC, low survival rate remains a major challenge, indicating the need for alternative approaches, ... -
Ziziphus nummularia Inhibits Inflammation-Induced Atherogenic Phenotype of Human Aortic Smooth Muscle Cells
Fardoun, Manal; Al-Shehabi, Tuqa; El-Yazbi, Ahmed; Issa, Khodr; Zouein, Fouad; Maaliki, Dina; Iratni, Rabah; Eid, Ali H.... more authors ... less authors ( Hindawi Limited , 2017 , Article)Cardiovascular disease (CVD) continues to be the leading cause of death worldwide. Atherosclerosis is a CVD characterized by plaque formation resulting from inflammation-induced insults to endothelial cells, monocytes, and ...