Browsing by Author "Iratni, Rabah"
Now showing items 1-20 of 29
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2-Nucleobase-substituted 4,6-Diaminotriazine Analogs: Synthesis and Anti-cancer Activity in 5-Fluorouracil-Sensitive and Resistant Colorectal Cancer Cells.
Hamze, Khalil; Abdallah, Rola H; Younis, Nour K; Fardoun, Manal; Darwiche, Nadine; Kobeissy, Firas; Iratni, Rabah; Bouhadir, Kamal; Eid, Ali H... more authors ... less authors ( Bentham Science Publishers , 2022 , Article)Cancer continues to be the second leading cause of death worldwide with colorectal cancer (CRC) being the third most common type. Despite significant advances in cancer therapies, current treatment of CRC remains suboptimal. ... -
Anti-atherosclerotic plants which modulate the phenotype of vascular smooth muscle cells
Al-Shehabi, Tuqa Saleh; Iratni, Rabah; Eid, Ali H. ( Elsevier , 2016 , Article)Background: Cardiovascular disease (CVD) remains the leading cause of global death, with atherosclerosis being a major contributor to this mortality. Several mechanisms are implicated in the pathogenesis of this disease. ... -
Anti-atherosclerotic plants which modulate the phenotype of vascular smooth muscle cells
Saleh Al-Shehabi, Tuqa; Iratni, Rabah; Eid, Ali H. ( Elsevier , 2016 , Article)Background: Cardiovascular disease (CVD) remains the leading cause of global death, with atherosclerosis being a major contributor to this mortality. Several mechanisms are implicated in the pathogenesis of this disease. ... -
Anti-Metastatic and Anti-Tumor Growth Effects of Origanum majorana on Highly Metastatic Human Breast Cancer Cells: Inhibition of NFκB Signaling and Reduction of Nitric Oxide Production
Al Dhaheri, Yusra; Attoub, Samir; Arafat, Kholoud; AbuQamar, Synan; Viallet, Jean; Saleh, Alaaeldin; Al Agha, Hala; Eid, Ali; Iratni, Rabah... more authors ... less authors ( Public Library of Science , 2013 , Article)Background: We have recently reported that Origanum majorana exhibits anticancer activity by promoting cell cycle arrest and apoptosis of the metastatic MDA-MB-231 breast cancer cell line. Here, we extended our study by ... -
C-peptide in diabetes: A player in a dual hormone disorder?
Dakroub, Ali; Dbouk, Ali; Asfour, Aref; Nasser, Suzanne A.; El-Yazbi, Ahmed F.; Sahebkar, Amirhossein; Eid, Assaad A.; Iratni, Rabah; Eid, Ali H.... more authors ... less authors ( Wiley-Blackwell , 2024 , Article)C-peptide, a byproduct of insulin synthesis believed to be biologically inert, is emerging as a multifunctional molecule. C-peptide serves an anti-inflammatory and anti-atherogenic role in type 1 diabetes mellitus (T1DM) ... -
Cadmium induces migration of colon cancer cells: Roles of reactive oxygen species, p38 and cyclooxygenase-2
Naji, Sara; Issa, Khodr; Eid, Assaad; Iratni, Rabah; Eid, Ali H. ( Cell Physiol Biochem Press GmbH & Co KG , 2019 , Article)Background/Aims: Cadmium (Cd) is a heavy metal contaminant whose toxicity is associated with colorectal cancer (CRC). However, the underlying molecular mechanisms of Cd-induced CRC malignancy remain obscure. Methods: A ... -
Carnosol Induces p38-Mediated ER Stress Response and Autophagy in Human Breast Cancer Cells
Alsamri, Halima; Alneyadi, Aysha; Muhammad, Khalid; Ayoub, Mohammed Akli; Eid, Ali; Iratni, Rabah... more authors ... less authors ( Frontiers , 2022 , Article)We recently reported that carnosol induces ROS-dependent autophagy and apoptosis in breast cancer cells. We also reported that carnosol inhibits breast cancer cell migration, invasion, and in ovo tumor growth, as well as ... -
Carnosol Is a Novel Inhibitor of p300 Acetyltransferase in Breast Cancer
Alsamri, Halima; Hasasna, Hussain El; Baby, Bincy; Alneyadi, Aysha; Dhaheri, Yusra Al; Ayoub, Mohammed Akli; Eid, Ali H.; Vijayan, Ranjit; Iratni, Rabah... more authors ... less authors ( Frontiers Media S.A. , 2021 , Article)Carnosol, a natural polyphenol abundant in edible plants such as sage, rosemary, and oregano, has shown promising anticancer activity against various types of cancers. Nonetheless, very little is known about its molecular ... -
Effect of Resveratrol on Pregnancy, Prenatal Complications and Pregnancy-Associated Structure Alterations.
Ramli, Iman; Posadino, Anna Maria; Giordo, Roberta; Fenu, Grazia; Fardoun, Manal; Iratni, Rabah; Eid, Ali H; Zayed, Hatem; Pintus, Gianfranco... more authors ... less authors ( MDPI , 2023 , Article Review)Adverse pregnancy outcomes are considered significant health risks for pregnant women and their offspring during pregnancy and throughout their lifespan. These outcomes lead to a perturbated in-utero environment that impacts ... -
Flavonoids in adipose tissue inflammation and atherosclerosis: One arrow, two targets
Fardoun, Manal Muin; Maaliki, Dina; Halabi, Nabil; Iratni, Rabah; Bitto, Alessandra; Baydoun, Elias; Eid, Ali H.... more authors ... less authors ( Portland Press Ltd , 2020 , Article Review)Flavonoids are polyphenolic compounds naturally occurring in fruits and vegetables, in addition to beverages such as tea and coffee. Flavonoids are emerging as potent therapeutic agents for cardiovascular as well as metabolic ... -
Lipid-lowering therapies for atherosclerosis: Statins, fibrates, ezetimibe and pcsk9 monoclonal antibodies
Ali, A.H.; Younis, Nour; Abdallah, Rola; Shaer, Farah; Dakroub, Ali; Ayoub, Mohammed Akli; Iratni, Rabah; Yassine, Hadi Mohamad; Zibara, Kazem; Orekhov, Alexander; El-Yazbi, Ahmed Fawzy; Eid, Ali H.... more authors ... less authors ( Bentham Science Publishers , 2021 , Article Review)Cardiovascular disease (CVD) remains the primary cause of global morbidity and mortality. CVD includes various life-threatening conditions such as myocardial infarction, stroke and peripheral arterial diseases. In this ... -
Marjoram Relaxes Rat Thoracic Aorta Via a PI3-K/eNOS/cGMP Pathway.
Badran, Adnan; Baydoun, Elias; Samaha, Ali; Pintus, Gianfranco; Mesmar, Joelle; Iratni, Rabah; Issa, Khodr; Eid, Ali H... more authors ... less authors ( MDPI , 2019 , Article)Despite pharmacotherapeutic advances, cardiovascular disease (CVD) remains the primary cause of global mortality. Alternative approaches, such as herbal medicine, continue to be sought to reduce this burden. is recognized ... -
Mitotic Arrest and Apoptosis in Breast Cancer Cells Induced by Origanum majorana Extract: Upregulation of TNF-α and Downregulation of Survivin and Mutant p53
Al Dhaheri, Yusra; Eid, Ali; AbuQamar, Synan; Attoub, Samir; Khasawneh, Mohammad; Aiche, Ghenima; Hisaindee, Soleiman; Iratni, Rabah... more authors ... less authors ( Public Library of Science , 2013 , Article)Background: In the present study, we investigated the effect of Origanum majorana ethanolic extract on the survival of the highly proliferative and invasive triple-negative p53 mutant breast cancer cell line MDA-MB-231. ... -
Origanum syriacum L. Attenuates the Malignant Phenotype of MDA-MB231 Breast Cancer Cells
AlKahlout, Amal; Fardoun, Manal; Mesmar, Joelle; Abdallah, Rola; Badran, Adnan; Nasser, Suzanne A.; Baydoun, Serine; Kobeissy, Firas; Shaito, Abdullah; Iratni, Rabah; Muhammad, Khalid; Baydoun, Elias; Eid, Ali H.... more authors ... less authors ( Frontiers Media , 2022 , Article)Breast cancer is the leading cause of cancer-related deaths among women. Among breast cancer types, triple negative breast cancer (TNBC) is the most aggressive, and is resistant to hormonal and chemotherapeutic treatments. ... -
Pharmacological and antioxidant activities of rhus coriaria l. (sumac)
Alsamri, Halima; Athamneh, Khawlah; Pintus, Gianfranco; Eid, Ali H.; Iratni, Rabah ( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)Rhus coriaria L. (Anacardiaceae), commonly known as sumac, is a commonly used spice, condiment, and flavoring agent, especially in the Mediterranean region. Owing to its bountiful beneficial values, sumac has been used in ... -
Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms
Altabbal, Suhib; Athamnah, Khawla; Rahma, Aaesha; Wali, Adil Farooq; Eid, Ali H.; Iratni, Rabah; Al Dhaheri, Yusra... more authors ... less authors ( MDPI , 2023 , Article)Cancer is the second most life-threatening disease and has become a global health and economic problem worldwide. Due to the multifactorial nature of cancer, its pathophysiology is not completely understood so far, which ... -
Repurposing Ivermectin for COVID-19: Molecular Aspects and Therapeutic Possibilities
Wehbe, Zena; Wehbe, Maya; Iratni, Rabah; Pintus, Gianfranco; Zaraket, Hassan; Yassine, Hadi M; Eid, Ali H... more authors ... less authors ( Frontiers Media , 2021 , Article)As of January 2021, SARS-CoV-2 has killed over 2 million individuals across the world. As such, there is an urgent need for vaccines and therapeutics to reduce the burden of COVID-19. Several vaccines, including mRNA, ... -
Rhus coriaria induces senescence and autophagic cell death in breast cancer cells through a mechanism involving p38 and ERK1/2 activation
El Hasasna, Hussain; Athamneh, Khawlah; Al Samri, Halima; Karuvantevida, Noushad; Al Dhaheri, Yusra; Hisaindee, Soleiman; Ramadan, Gaber; Al Tamimi, Nedaa; AbuQamar, Synan; Eid, Ali; Iratni, Rabah... more authors ... less authors ( Nature Publishing Group , 2015 , Article)Here, we investigated the anticancer effect of Rhus coriaria on three breast cancer cell lines. We demonstrated that Rhus coriaria ethanolic extract (RCE) inhibits the proliferation of these cell lines in a time- and ... -
Rhus coriaria L. (Sumac) evokes endothelium-dependent vasorelaxation of rat aorta: Involvement of the cAMP and cGMP pathways
Anwar, Mohammad A.; Samaha, Ali A.; Baydoun, Safaa; Iratni, Rabah; Eid, Ali H. ( Frontiers Media S.A. , 2018 , Article)Rhus coriaria L. (sumac) is widely used in traditional remedies and cuisine of countries of the Mediterranean as well as Central and South-West Asia. Administration of sumac to experimental models and patients with diverse ... -
Rhus coriaria suppresses angiogenesis, metastasis and tumor growth of breast cancer through inhibition of STAT3, NFκB and nitric oxide pathways
El Hasasna, Hussain; Saleh, Alaaeldin; Al Samri, Halima; Athamneh, Khawlah; Attoub, Samir; Arafat, Kholoud; Benhalilou, Nehla; Alyan, Sofyan; Viallet, Jean; Al Dhaheri, Yusra; Eid, Ali; Iratni, Rabah... more authors ... less authors ( Nature Publishing Group , 2016 , Article)Recently, we reported that Rhus coriaria exhibits anticancer activities by promoting cell cycle arrest and autophagic cell death of the metastatic triple negative MDA-MB-231 breast cancer cells. Here, we investigated the ...