Browsing by Author "Iratni, Rabah"
Now showing items 1-15 of 15
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2-Nucleobase-substituted 4,6-Diaminotriazine Analogs: Synthesis and Anti-cancer Activity in 5-Fluorouracil-Sensitive and Resistant Colorectal Cancer Cells.
Hamze, Khalil; Abdallah, Rola H; Younis, Nour K; Fardoun, Manal; Darwiche, Nadine; Kobeissy, Firas; Iratni, Rabah; Bouhadir, Kamal; Eid, Ali H... more authors ... less authors ( Bentham Science Publishers , 2022 , Article)Cancer continues to be the second leading cause of death worldwide with colorectal cancer (CRC) being the third most common type. Despite significant advances in cancer therapies, current treatment of CRC remains suboptimal. ... -
C-peptide in diabetes: A player in a dual hormone disorder?
Dakroub, Ali; Dbouk, Ali; Asfour, Aref; Nasser, Suzanne A.; El-Yazbi, Ahmed F.; Sahebkar, Amirhossein; Eid, Assaad A.; Iratni, Rabah; Eid, Ali H.... more authors ... less authors ( Wiley-Blackwell , 2024 , Article)C-peptide, a byproduct of insulin synthesis believed to be biologically inert, is emerging as a multifunctional molecule. C-peptide serves an anti-inflammatory and anti-atherogenic role in type 1 diabetes mellitus (T1DM) ... -
Carnosol Induces p38-Mediated ER Stress Response and Autophagy in Human Breast Cancer Cells
Alsamri, Halima; Alneyadi, Aysha; Muhammad, Khalid; Ayoub, Mohammed Akli; Eid, Ali; Iratni, Rabah... more authors ... less authors ( Frontiers , 2022 , Article)We recently reported that carnosol induces ROS-dependent autophagy and apoptosis in breast cancer cells. We also reported that carnosol inhibits breast cancer cell migration, invasion, and in ovo tumor growth, as well as ... -
Carnosol Is a Novel Inhibitor of p300 Acetyltransferase in Breast Cancer
Alsamri, Halima; Hasasna, Hussain El; Baby, Bincy; Alneyadi, Aysha; Dhaheri, Yusra Al; Ayoub, Mohammed Akli; Eid, Ali H.; Vijayan, Ranjit; Iratni, Rabah... more authors ... less authors ( Frontiers Media S.A. , 2021 , Article)Carnosol, a natural polyphenol abundant in edible plants such as sage, rosemary, and oregano, has shown promising anticancer activity against various types of cancers. Nonetheless, very little is known about its molecular ... -
Effect of Resveratrol on Pregnancy, Prenatal Complications and Pregnancy-Associated Structure Alterations.
Ramli, Iman; Posadino, Anna Maria; Giordo, Roberta; Fenu, Grazia; Fardoun, Manal; Iratni, Rabah; Eid, Ali H; Zayed, Hatem; Pintus, Gianfranco... more authors ... less authors ( MDPI , 2023 , Article Review)Adverse pregnancy outcomes are considered significant health risks for pregnant women and their offspring during pregnancy and throughout their lifespan. These outcomes lead to a perturbated in-utero environment that impacts ... -
Lipid-lowering therapies for atherosclerosis: Statins, fibrates, ezetimibe and pcsk9 monoclonal antibodies
Ali, A.H.; Younis, Nour; Abdallah, Rola; Shaer, Farah; Dakroub, Ali; Ayoub, Mohammed Akli; Iratni, Rabah; Yassine, Hadi Mohamad; Zibara, Kazem; Orekhov, Alexander; El-Yazbi, Ahmed Fawzy; Eid, Ali H.... more authors ... less authors ( Bentham Science Publishers , 2021 , Article Review)Cardiovascular disease (CVD) remains the primary cause of global morbidity and mortality. CVD includes various life-threatening conditions such as myocardial infarction, stroke and peripheral arterial diseases. In this ... -
Origanum syriacum L. Attenuates the Malignant Phenotype of MDA-MB231 Breast Cancer Cells
AlKahlout, Amal; Fardoun, Manal; Mesmar, Joelle; Abdallah, Rola; Badran, Adnan; Nasser, Suzanne A.; Baydoun, Serine; Kobeissy, Firas; Shaito, Abdullah; Iratni, Rabah; Muhammad, Khalid; Baydoun, Elias; Eid, Ali H.... more authors ... less authors ( Frontiers Media , 2022 , Article)Breast cancer is the leading cause of cancer-related deaths among women. Among breast cancer types, triple negative breast cancer (TNBC) is the most aggressive, and is resistant to hormonal and chemotherapeutic treatments. ... -
Pharmacological and antioxidant activities of rhus coriaria l. (sumac)
Alsamri, Halima; Athamneh, Khawlah; Pintus, Gianfranco; Eid, Ali H.; Iratni, Rabah ( Multidisciplinary Digital Publishing Institute (MDPI) , 2021 , Article)Rhus coriaria L. (Anacardiaceae), commonly known as sumac, is a commonly used spice, condiment, and flavoring agent, especially in the Mediterranean region. Owing to its bountiful beneficial values, sumac has been used in ... -
Propolis: A Detailed Insight of Its Anticancer Molecular Mechanisms
Altabbal, Suhib; Athamnah, Khawla; Rahma, Aaesha; Wali, Adil Farooq; Eid, Ali H.; Iratni, Rabah; Al Dhaheri, Yusra... more authors ... less authors ( MDPI , 2023 , Article)Cancer is the second most life-threatening disease and has become a global health and economic problem worldwide. Due to the multifactorial nature of cancer, its pathophysiology is not completely understood so far, which ... -
Rhus coriaria induces senescence and autophagic cell death in breast cancer cells through a mechanism involving p38 and ERK1/2 activation
El Hasasna, Hussain; Athamneh, Khawlah; Al Samri, Halima; Karuvantevida, Noushad; Al Dhaheri, Yusra; Hisaindee, Soleiman; Ramadan, Gaber; Al Tamimi, Nedaa; AbuQamar, Synan; Eid, Ali; Iratni, Rabah... more authors ... less authors ( Nature Publishing Group , 2015 , Article)Here, we investigated the anticancer effect of Rhus coriaria on three breast cancer cell lines. We demonstrated that Rhus coriaria ethanolic extract (RCE) inhibits the proliferation of these cell lines in a time- and ... -
Rhus coriaria L. (Sumac) evokes endothelium-dependent vasorelaxation of rat aorta: Involvement of the cAMP and cGMP pathways
Anwar, Mohammad A.; Samaha, Ali A.; Baydoun, Safaa; Iratni, Rabah; Eid, Ali H. ( Frontiers Media S.A. , 2018 , Article)Rhus coriaria L. (sumac) is widely used in traditional remedies and cuisine of countries of the Mediterranean as well as Central and South-West Asia. Administration of sumac to experimental models and patients with diverse ... -
Rhus coriaria suppresses angiogenesis, metastasis and tumor growth of breast cancer through inhibition of STAT3, NFκB and nitric oxide pathways
El Hasasna, Hussain; Saleh, Alaaeldin; Al Samri, Halima; Athamneh, Khawlah; Attoub, Samir; Arafat, Kholoud; Benhalilou, Nehla; Alyan, Sofyan; Viallet, Jean; Al Dhaheri, Yusra; Eid, Ali; Iratni, Rabah... more authors ... less authors ( Nature Publishing Group , 2016 , Article)Recently, we reported that Rhus coriaria exhibits anticancer activities by promoting cell cycle arrest and autophagic cell death of the metastatic triple negative MDA-MB-231 breast cancer cells. Here, we investigated the ... -
Role of RhoA and Rho-associated kinase in phenotypic switching of vascular smooth muscle cells: Implications for vascular function
Tedy, Sawma; Shaito, Abdullah; Najm, Nicolas; Sidani, Munir; Orekhov, Alexander; El-Yazbi, Ahmed F.; Iratni, Rabah; Eid, Ali H.... more authors ... less authors ( Elsevier , 2022 , Article Review)Cardiovascular disease (CVD) continues to be the primary cause of global mortality. Vascular smooth muscle cells (VSMCs) are integral components of vascular structure and function, evident by their vital roles in modulating ... -
The SARS-CoV-2 Spike Protein Activates the Epidermal Growth Factor Receptor-Mediated Signaling
Palakkott, Abdul Rasheed; Alneyadi, Aysha; Muhammad, Khalid; Eid, Ali Hussein; Amiri, Khaled M.A.; Akli Ayoub, Mohammed; Iratni, Rabah... more authors ... less authors ( MDPI , 2023 , Article)The coronavirus disease-19 (COVID-19) pandemic is caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). At the molecular and cellular levels, the SARS-CoV-2 uses its envelope glycoprotein, the ... -
Ziziphus nummularia attenuates the malignant phenotype of human pancreatic cancer cells: Role of ros
Mesmar, J.; Mesmar, Joelle; Fardoun, Manal M.; Abdallah, Rola; Al Dhaheri, Yusra; Yassine, Hadi M.; Iratni, Rabah; Badran, Adnan; Eid, Ali H.; Baydoun, Elias... more authors ... less authors ( MDPI AG , 2021 , Article)Pancreatic cancer (PC) is the fourth leading cause of all cancer-related deaths. Despite major improvements in treating PC, low survival rate remains a major challenge, indicating the need for alternative approaches, ...