Browsing by Author "Elhissi, Abdelbary"
Now showing items 21-32 of 32
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Letrozole-loaded nonionic surfactant vesicles prepared via a slurry-based proniosome technology: Formulation development and characterization
Nada, Khudair; Agouni, Abdelali; Elrayess, Mohamed A.; Najlah, Mohammad; Younes, Husam M.; Elhissi, Abdelbary... more authors ... less authors ( Elsevier , 2020 , Article)Slurry-based Letrozole (LTZ)-loaded proniosomes were designed using sucrose or sorbitol as carriers and various ratios of cholesterol (CH) and Tween 80 (T80) as lipid composition. Proniosomes were hydrated and probe-sonicated ... -
Liposome mediated-CYP1A1 gene silencing nanomedicine prepared using lipid film-coated proliposomes as a potential treatment strategy of lung cancer.
Zhang, Mengtian; Wang, Qin; Wan, Ka-Wai; Ahmed, Waqar; Phoenix, David A; Zhang, Zhirong; Elrayess, Mohamed A; Elhissi, Abdelbary; Sun, Xun... more authors ... less authors ( Elsevier , 2019 , Article)The occurrence of lung cancer is linked with tobacco smoking, mainly through the generation of polycyclic aromatic hydrocarbons (PAHs). Elevated activity of cytochrome P4501A1 (CYP1A1) plays an important role in the metabolic ... -
Liposomes for pulmonary drug delivery: The role of formulation and inhalation device design
Elhissi, Abdelbary ( Bentham Science Publishers B.V. , 2017 , Article Review)Liposomes are established drug carriers for inhalation owing to their safety and ability to provide controlled drug release in the lung. These carriers can entrap a wide range of therapeutic molecules for delivery in large ... -
Norfloxacin loaded lipid polymer hybrid nanoparticles for oral administration: Fabrication, characterization, in silico modelling and toxicity evaluation
Khan, Muhammad A.; Khan, Shahzeb; Kazi, Mohsin; Alshehri, Sultan M.; Shahid, Muhammad; Khan, Shafi U.; Hussain, Zahid; Sohail, Muhammad; Shafique, Muhammad; Hamid, Hajra A.; Kamran, Mahwish; Elhissi, Abdelbary; Wasim, Muhammad; Thu, Hnin E.... more authors ... less authors ( MDPI , 2021 , Article)Norfloxacin (NOR), widely employed as an anti-bacterial drug, has poor oral bioavailability. Nano based drug delivery systems are widely used to overcome the existing oral bioavailability challenges. Lipid–Polymer Hybrid ... -
Paclitaxel-loaded micro or nano transfersome formulation into novel tablets for pulmonary drug delivery via nebulization
Iftikhar, Khan; Apostolou, Maria; Bnyan, Ruba; Houacine, Chahinez; Elhissi, Abdelbary; Yousaf, Sakib S... more authors ... less authors ( Elsevier , 2020 , Article)A simplistic approach was adopted to manufacture novel paclitaxel (PTX) loaded protransfersome tablet formulations for pulmonary drug delivery. The large surface area offered by the pulmonary system acts as a desirable ... -
Piroxicam loaded polymer hybrid microspheres based tablets with modified release kinetics: Development, characterization and in vivo evaluation
Hamid, Hajra Afeera; Khan, Shahzeb; Shah, Syed Muhammad Noor; Asghar, Muhammad.; Shahid, Muhammad; Hussain, Zahid; Sohail, Muhammad; Khan, Barkat Ali; Amin, Fazli; Jan, Syed Umer; Elhissi, Abdelbary; Shah, Syed Muhammad Hassan; Minhas, Muhammad Usman; Shah, Syed Wadood Ali; Ahmad, Naveed... more authors ... less authors ( Pakistan Journal of Pharmaceutical Sciences , 2021 , Article)Piroxicam (PC) is a non-steroidal anti-inflammatory drug characterized by poor aqueous solubility and reported to cause and impart crucial GIT irritation, bleeding, peptic and duodenal ulcer. Engineering of PC ... -
Preparation and Characterization of Letrozole-Loaded Poly (D,L-Lactide) Nanoparticles for Breast Cancer Therapy
Alemrayat, Bayan; Elhissi, Abdelbary; Younes, Husam ( Hamad bin Khalifa University Press (HBKU Press) , 2016 , Conference Paper)Introduction: Breast cancer has been ranked first as the most prevalent type of cancer and the leading cause of cancer-related mortality among women worldwide. Letrozole (LTZ), an aromatase inhibitor, has been shown to be ... -
Proliposome powder or tablets for generating inhalable liposomes using a medical nebulizer
Khan, Iftikhar; Yousaf, Sakib; Najlah, Mohammad; Ahmed, Waqar; Elhissi, Abdelbary ( Springer , 2021 , Article)© 2020, The Author(s). Purpose: The aim of this study was to develop and compare proliposome powder and proliposome tablet formulations for drug delivery from a Pari-LC Sprint nebulizer. Methods: Proliposome powders were ... -
Proliposome Powders for the Generation of Liposomes: the Influence of Carbohydrate Carrier and Separation Conditions on Crystallinity and Entrapment of a Model Antiasthma Steroid
Khan, Iftikhar; Yousaf, Sakib; Subramanian, Sneha; Alhnan, Mohamed AlbedAhmed, Waqar; Elhissi, Abdelbary ( Springer New York LLC , 2018 , Article)Formulation effects on the entrapment of beclometasone dipropionate (BDP) in liposomes generated by hydration of proliposomes were studied, using the high-density dispersion medium deuterium oxide in comparison to deionized ... -
Proliposome powders prepared using a slurry method for the generation of beclometasone dipropionate liposomes
Khan, Iftikhar; Yousaf, Sakib; Subramanian, Sneha; Korale, Oshadie; Alhnan, Mohamed Albed; Ahmed, Waqar; Taylor, Kevin M.G.; Elhissi, Abdelbary... more authors ... less authors ( Elsevier , 2015 , Article)A novel “slurry method” was described for the preparation of proliposome powders using soya phosphatidylcholine (SPC) with cholesterol (1:1) and for incorporation of beclometasone dipropionate (BDP) at 2mole% of the total ... -
Recent advancements in stimuli responsive drug delivery platforms for active and passive cancer targeting
Rahim, Muhammad A.; Jan, Nasrullah; Khan, Safiullah; Shah, Hassan; Madni, Asadullah; Khan, Arshad; Jabar, Abdul; Khan, Shahzeb; Elhissi, Abdelbary; Hussain, Zahid; Aziz, Heather C.; Sohail, Muhammad; Khan, Mirazam; Thu, Hnin E.... more authors ... less authors ( MDPI AG , 2021 , Article Review)The tumor-specific targeting of chemotherapeutic agents for specific necrosis of cancer cells without affecting the normal cells poses a great challenge for researchers and scientists. Though extensive research has been ... -
Spray-Dried Alginate Microparticles for Potential Intranasal Delivery of Ropinirole Hydrochloride: Development, Characterization and Histopathological Evaluation
Hussein, Nozad; Omer, Huner; Ismael, Ava; Alhnan, Mohamed; Elhissi, Abdelbary; Ahmed, Waqar... more authors ... less authors ( Taylor & Francis , 2019 , Article)Ropinirole hydrochloride (RH) is an anti-Parkinson drug with relativity low oral bioavailability owing to its extensive hepatic first pass metabolism. Spray-dried mucoadhesive alginate microspheres of RH were developed and ...