Browsing by Author "Gupta, Ishita"

Now showing items 1-19 of 19

    • Circulating miRNAs in HER2-Positive and Triple Negative Breast Cancers: Potential Biomarkers and Therapeutic Targets. 

      Gupta, Ishita; Rizeq, Balsam; Vranic, Semir; Moustafa, Ala-Eddin Al; Al Farsi, Halema ( MDPI , 2020 , Article)
      Breast cancer is one of the most prevalent diseases among women worldwide and is highly associated with cancer-related mortality. Of the four major molecular subtypes, HER2-positive and triple-negative breast cancer (TNBC) ...

    • Co‑prevalence of human Papillomaviruses (HPV) and Epstein–Barr virus (EBV) in healthy blood donors from diverse nationalities in Qatar 

      Gupta, Ishita; Nasrallah, Gheyath; Sharma, Anju; Jabeen, Ayesha; Smatti, Maria; ... more authors ( BMC , 2020 , Article)
      Background: Infections by both human oncoviruses, human Papillomaviruses (HPV) and Epstein–Barr virus (EBV) are very common in the adult human population and are associated with various malignancies. While HPV is ...

    • Dasatinib and PD-L1 inhibitors provoke toxicity and inhibit angiogenesis in the embryo 

      Maha, Al-Asmakh; Bawadi, Hiba; Hamdan, Munia; Gupta, Ishita; Kheraldine, Hadeel; ... more authors ( Elsevier , 2021 , Article)
      Dasatinib is a targeted cancer therapy, while programmed death ligand 1 (PD-L1) inhibitors are a form of immune checkpoint therapy used to treat various types of cancers. Several studies showed the potential efficacy of ...

    • Elaeagnus angustifolia Plant Extract Induces Apoptosis via P53 and Signal Transducer and Activator of Transcription 3 Signaling Pathways in Triple-Negative Breast Cancer Cells 

      Fouzat, Arij; Hussein, Ola Jihad; Gupta, Ishita; Al-Farsi, Halema F.; Khalil, Ashraf; ... more authors ( Frontiers Media , 2022 , Article)
      Elaeagnus angustifolia (EA) is used as an alternative medicine in the Middle East to manage numerous human diseases. We recently reported that EA flower extract inhibits cell proliferation and invasion of human oral and ...

    • Elaeagnus angustifolia Plant Extract Inhibits Epithelial-Mesenchymal Transition and Induces Apoptosis via HER2 Inactivation and JNK Pathway in HER2-Positive Breast Cancer Cells 

      Jabeen, Ayesha; Sharma, Anju; Gupta, Ishita; Kheraldine, Hadeel; Vranic, Semir; ... more authors ( MDPI , 2020 , Article)
      Elaeagnus angustifolia (EA) is a medicinal plant used for treating several human diseases in the Middle East. Meanwhile, the outcome of extract on HER2-positive breast cancer remains nascent. Thus, we herein investigated ...

    • Forecasting the effects of smoking prevalence scenarios on years of life lost and life expectancy from 2022 to 2050: a systematic analysis for the Global Burden of Disease Study 2021 

      Dana, Bryazka; Reitsma, Marissa B; Abate, Yohannes Habtegiorgis; Abd Al Magied, Abdallah H A; Abdelkader, Atef; ... more authors ( Elsevier , 2024 , Article)
      BackgroundSmoking is the leading behavioural risk factor for mortality globally, accounting for more than 175 million deaths and nearly 4·30 billion years of life lost (YLLs) from 1990 to 2021. The pace of decline in smoking ...

    • Global, regional, and national burden of headache disorders, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023 

      Husøy, Andreas Kattem; Xu, Yvonne Yiru; Steinmetz, Jaimie D; Aalipour, Mohammad Amin; Aalruz, Hasan; ... more authors ( Elsevier , 2025 , Article)
      BackgroundThe Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2023 estimates health loss from migraine, tension-type headache, and medication-overuse headache. This study presents updated results on ...

    • Helicobacter pylori and epithelial mesenchymal transition in human gastric cancers: An update of the literature 

      Jamal Eddin, Tala M.; Nasr, Shahd M.O.; Gupta, Ishita; Zayed, Hatem; Al Moustafa, Ala-Eddin ( Elsevier , 2023 , Article Review)
      Gastric cancer, a multifactorial disease, is considered one of the most common malignancies worldwide. In addition to genetic and environmental risk factors, infectious agents, such as Epstein-Barr virus (EBV) and Helicobacter ...

    • High-Risk Human Papillomaviruses and Epstein-Barr Virus in Colorectal Cancer and Their Association with Clinicopathological Status. 

      Gupta, Ishita; Al Farsi, Halema; Jabeen, Ayesha; Skenderi, Faruk; Al-Thawadi, Hamda; ... more authors ( MDPI , 2020 , Article)
      Colorectal cancer (CRC) is a common malignancy with a high mortality rate worldwide. It is a complex, multifactorial disease that is strongly impacted by both hereditary and environmental factors. The role of microbes ...

    • Incidence and association of high-risk HPVs and EBV in patients with advanced stages of colorectal cancer from Qatar 

      Fernandes, Queenie; Gupta, Ishita; Murshed, Khaled; Samra, Hayan Abo; Al-Thawadi, Hamda; ... more authors ( Taylor and Francis Ltd. , 2023 , Article)
      High-risk Human Papillomaviruses (HPVs) and Epstein-Barr virus (EBV) are present and involved in several types of human carcinomas, including cervical and, head and neck cancers. Nevertheless, their presence and association ...

    • Incidence of HPVs, EBV and MMTV-like Virus in Breast Cancer in Qatar. 

      Gupta, Ishita; Al-Sarraf, Reem; Farghaly, Hanan; Vranic, Semir; Sultan, Ali A; ... more authors ( Karger Publishers , 2022 , Article)
      Human papillomaviruses (HPVs), Epstein-Barr virus (EBV), and mouse mammary tumor virus-like virus (MMTV-like virus) can be present and contribute to breast cancer development and progression. However, the role of these ...

    • Mesoporous silica coated carbon nanofibers reduce embryotoxicity via ERK and JNK pathways 

      Abdo, Ghada G.; Gupta, Ishita; Kheraldine, Hadeel; Rizeq, Balsam; Zagho, Moustafa M.; ... more authors ( Elsevier Ltd , 2021 , Article)
      Carbon nanofibers (CNFs) have been implicated in biomedical applications, yet, they are still considered as a potential hazard. Conversely, mesoporous silica is a biocompatible compound that has been used in various ...

    • Novel nitrogen-based chalcone analogs provoke substantial apoptosis in HER2-positive human breast cancer cells via JNK and ERK1/ERK2 signaling pathways 

      Rizeq, Balsam; Gupta, Ishita; Kheraldine, Hadeel; Elkhalifa, Dana; Al-Farsi, Halema F.; ... more authors ( MDPI , 2021 , Article)
      Natural chalcones possess antitumor properties and play a role as inducers of apoptosis, antioxidants and cytotoxic compounds. We recently reported that novel nitrogen chalcone-based compounds, which were generated in our ...

    • Quantification of the growth suppression of HER2+ breast cancer colonies under the effect of trastuzumab and PD-1/PD-L1 inhibitor. 

      Padmanabhan, Regina; Kheraldine, Hadeel; Gupta, Ishita; Meskin, Nader; Hamad, Anas; ... more authors ( Frontiers Media , 2022 , Article)
      Immune checkpoint blockade (ICB)-based therapy is revolutionizing cancer treatment by fostering successful immune surveillance and effector cell responses against various types of cancers. However, patients with HER2+ ...

    • Role of E2F transcription factor in oral cancer: Recent insight and advancements 

      Amal, Kassab; Gupta, Ishita; Moustafa, Ala-Eddin Al ( Elsevier , 2023 , Article)
      The family of mammalian E2F transcription factors (E2Fs) comprise of 8 members (E2F1-E2F8) classified as activators (E2F1-E2F3) and repressors (E2F4-E2F8) primarily regulating the expression of several genes related to ...

    • SOD2, a Potential Transcriptional Target Underpinning CD44-Promoted Breast Cancer Progression 

      Alateyah, Nouralhuda; Gupta, Ishita; Rusyniak, Radoslaw Stefan; Ouhtit, Allal ( MDPI , 2022 , Article Review)
      CD44, a cell-adhesion molecule has a dual role in tumor growth and progression; it acts as a tumor suppressor as well as a tumor promoter. In our previous work, we developed a tetracycline-off regulated expression of CD44’s ...

    • Targeting HER2-positive breast cancer cells by a combination of dasatinib and BMS-202: Insight into the molecular pathways. 

      Kheraldine, Hadeel; Gupta, Ishita; Cyprian, Farhan Sachal; Vranic, Semir; Al-Farsi, Halema F; ... more authors ( Springer Nature , 2024 , Article)
      Recent investigations have reported the benefits of using a tyrosine kinase inhibitor, dasatinib (DA), as well as programmed death-ligand 1 (PD-L1) inhibitors in the management of several solid tumors, including breast ...

    • The burden of diseases, injuries, and risk factors by state in the USA, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021 

      Mokdad, Ali H.; Bisignano, Catherine; Hsu, Johnathan M.; Ababneh, Hazim S.; Abbasgholizadeh, Rouzbeh; ... more authors ( Elsevier , 2024 , Article)
      Background The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides a comprehensive assessment of health and risk factor trends at global, regional, national, and subnational levels. This study ...

    • The power of phytochemicals combination in cancer chemoprevention 

      Rizeq, Balsam; Gupta, Ishita; Ilesanmi, Josephine; AlSafran, Mohammed; Rahman, MD Mizanur; ... more authors ( Ivyspring International Publisher , 2020 , Article Review)
      Conventional therapies for cancer treatment have posed many challenges, including toxicity, multidrug resistance and economic expenses. In contrast, complementary alternative medicine (CAM), employing phytochemicals have ...