Browsing by Author "Chouchane, Lotfi"

Now showing items 1-3 of 3

    • A population study of clinically actionable genetic variation affecting drug response from the Middle East 

      Jithesh, Puthen Veettil; Abuhaliqa, Mohammed; Syed, Najeeb; Ahmed, Ikhlak; El Anbari, Mohammed; ... more authors ( Nature Research , 2022 , Article)
      Clinical implementation of pharmacogenomics will help in personalizing drug prescriptions and alleviate the personal and financial burden due to inefficacy and adverse reactions to drugs. However, such implementation is ...

    • Discovery of new therapeutic targets in ovarian cancer through identifying significantly non-mutated genes 

      Al-Farsi, Halema; Al-Azwani, Iman; Malek, Joel A.; Chouchane, Lotfi; Rafii, Arash; ... more authors ( BioMed Central Ltd , 2022 , Article)
      Background: Mutated and non-mutated genes interact to drive cancer growth and metastasis. While research has focused on understanding the impact of mutated genes on cancer biology, understanding non-mutated genes that are ...

    • Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes 

      Razali, Rozaimi Mohamad; Rodriguez-Flores, Juan; Ghorbani, Mohammadmersad; Naeem, Haroon; Aamer, Waleed; ... more authors ( Nature Research , 2021 , Article)
      Arab populations are largely understudied, notably their genetic structure and history. Here we present an in-depth analysis of 6,218 whole genomes from Qatar, revealing extensive diversity as well as genetic ancestries ...