تصفح حسب المؤلف "Carlus, F. H."
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An in silico analysis of the impact of POLE mutations on cladribine docking
Loganathan, L.; Al-Haidose, A.; Ganesh Kumar, A.; Sujatha, L. B.; Carlus, F. H.; Alharbi, A.; Alhyassat, S.; Muthusamy, K.; Carlus, S. J.; Abdallah, A. M.... more authors ... less authors ( Verduci Editore srl , 2022 , Article)OBJECTIVE: Polymerase ε exonuclease (POLE) is an enzyme involved in DNA replication and may be an attractive therapeutic target in various cancers. Here we sought to model the impact of specific POLE mutations on protein ... -
A novel homozygous TPM1 mutation in familial pediatric hypertrophic cardiomyopathy and in silico screening of potential targeting drugs.
Carlus, S J; Almuzaini, I S; Karthikeyan, M; Loganathan, L; Al-Harbi, G S; Carlus, F H; Al-Mazroea, A H; Morsy, M M; Abo-Haded, H M; Abdallah, A M; Al-Harbi, K M... more authors ... less authors ( Verduci Editore s.r.l. , 2020 , Article)Familial hypertrophic cardiomyopathy (HCM) is the most common genetic cardiac disease. While sarcomeric gene mutations explain many HCM cases, the genetic basis of about half of HCM cases remains elusive. Here we aimed to ...