تصفح حسب المؤلف "Giordo, Roberta"
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Activation of the Pro-Oxidant PKCβII-p66Shc Signaling Pathway Contributes to Pericyte Dysfunction in Skeletal Muscles of Diabetic Patients with Critical Limb Ischemia
Vono, Rosa; Fuoco, Claudio; Testa, Stefano; Pirrò, Stefano; Maselli, Davide; McCollough, David Ferland; Sangalli, Elena; Pintus, Gianfranco; Giordo, Roberta; Finzi, Giovanna; Sessa, Fausto; Cardani, Rosanna; Gotti, Ambra; Losa, Sergio; Cesareni, Gianni; Rizzi, Roberto; Bearzi, Claudia; Cannata, Stefano; Spinetti, Gaia; Gargioli, Cesare; Madeddu, Paolo... more authors ... less authors ( American Diabetes Association , 2016 , Article)Critical limb ischemia (CLI), foot ulcers, former amputation and impaired regeneration are independent risk factors for limb amputation in diabetic subjects. The present work investigates whether and by which mechanism ... -
Cytoprotective, antioxidant, and anti-migratory activity of Pistacia lentiscus L. supercritical carbon dioxide extract on primary human endothelial cells
Giordo, Roberta; Cossu, Annalisa; Porcu, Maria Cristina; Cappuccinelli, Roberto; Biosa, Grazia; Sharifi-Rad, Javad; Pretti, Luca; Nasrallah, Gheyath K.; Pintus, Gianfranco; Posadino, Anna Maria... more authors ... less authors ( Taylor & Francis , 2022 , Article)Green chemistry is a useful tool for producing valuable chemicals from biomass. However, extracted compounds need to be tested for safety and efficacy before their use in humans. Here we investigate the chemical composition ... -
Effect of Resveratrol on Pregnancy, Prenatal Complications and Pregnancy-Associated Structure Alterations.
Ramli, Iman; Posadino, Anna Maria; Giordo, Roberta; Fenu, Grazia; Fardoun, Manal; Iratni, Rabah; Eid, Ali H; Zayed, Hatem; Pintus, Gianfranco... more authors ... less authors ( MDPI , 2023 , Article Review)Adverse pregnancy outcomes are considered significant health risks for pregnant women and their offspring during pregnancy and throughout their lifespan. These outcomes lead to a perturbated in-utero environment that impacts ... -
EndMT regulation by small RNAs in diabetes-associated fibrotic conditions: potential link with oxidative stress
Giordo, Roberta; Mohammed, Yusra; Allam, Hilda; Abusnana, Salah; Pappalardo, Lucia; Nasrallah, Gheyath; Mangoni, Arduino; Pintus, Gianfranco... more authors ... less authors ( Frontiers Media , 2021 , Article)Diabetes-associated complications, such as retinopathy, nephropathy, cardiomyopathy, and atherosclerosis, the main consequences of long-term hyperglycemia, often lead to organ dysfunction, disability, and increased mortality. ... -
Implications and theragnostic potentials of circular RNAs in rheumatic diseases
Alaa Ahmed, Abbas; Abdulkader, Hadil Adnan; Giordo, Roberta; Ashour, Hossam M.; Erre, Gian Luca; Pintus, Gianfranco; Zayed, Hatem... more authors ... less authors ( Elsevier , 2023 , Article Review)Circular RNAs (circRNAs), a class of non-coding RNAs (ncRNAs), are highly stable and ubiquitous molecules that exhibit tissue-specific expression. Accumulating evidence has shown that aberrant expression of circRNAs can ... -
NADPH-derived ROS generation drives fibrosis and endothelial-to-mesenchymal transition in systemic sclerosis: Potential cross talk with circulating miRNAs
Posadino, Anna Maria; Erre, Gian Luca; Cossu, Annalisa; Emanueli, Costanza; Eid, Ali H.; Zinellu, Angelo; Pintus, Gianfranco; Giordo, Roberta... more authors ... less authors ( Walter de Gruyter , 2022 , Article)Systemic sclerosis (SSc) is an immune disorder characterized by diffuse fibrosis and vascular abnormalities of the affected organs. Although the etiopathology of this disease is largely unknown, endothelial damage and ... -
Non-coding RNAs as biomarkers of myocardial infarction
Almaghrbi, Heba; Giordo, Roberta; Pintus, Gianfranco; Zayed, Hatem ( Elsevier , 2023 , Article)Non-coding RNAs (ncRNAs) encompass a family of ubiquitous RNA molecules that lack protein-coding potential and have tissue-specific expression. A significant body of evidence indicates that ncRNA's aberrant expression plays ... -
Potential Therapeutic Targets of Resveratrol in the Prevention and Treatment of Pulmonary Fibrosis
Ramli, Iman; Cheriet, Thamere; Posadino, Anna Maria; Giordo, Roberta; Zayed, Hatem; Eid, Ali H.; Pintus, Gianfranco... more authors ... less authors ( IMR Press Limited , 2023 , Article)Pulmonary fibrosis (PF) is a feared component in over 200 interstitial pulmonary diseases, which are characterized by increased alveolar wall thickness, excessive scarring, and aberrant extracellular matrix restructuring ... -
Resveratrol Inhibits Oxidative Stress and Prevents Mitochondrial Damage Induced by Zinc Oxide Nanoparticles in Zebrafish (Danio rerio)
Giordo, Roberta; Nasrallah, Gheyath; Al-Jamal, Ola; Paliogiannis, Panagiotis; Pintus, Gianfranco ( MDPI , 2020 , Article)Despite their wide industrial use, Zinc oxide (ZnO) nanoparticles (NPs) exhibit a high toxic potential while concerns of their health-related risks are still present, urging additional in vivo clarification studies. ... -
Resveratrol-Elicited PKC Inhibition Counteracts NOX-Mediated Endothelial to Mesenchymal Transition in Human Retinal Endothelial Cells Exposed to High Glucose
Giordo, Roberta; Nasrallah, Gheyath K.; Posadino, Anna Maria; Galimi, Francesco; Capobianco, Giampiero; Eid, Ali Hussein; Pintus, Gianfranco... more authors ... less authors ( MDPI , 2021 , Article)Diabetes-associated long-term hyperglycaemia leads to oxidative stress-mediated fibrosis in different tissues and organs. Endothelial-to-mesenchymal-transition (EndMT) appears to play a role in diabetes-associated fibrotic ... -
Resveratrol-mediated regulation of mitochondria biogenesis-associated pathways in neurodegenerative diseases: molecular insights and potential therapeutic applications.
Shaito, Abdullah; Al-Mansoob, Maryam; Ahmad, Salma M S; Haider, Mohammad Z; Eid, Ali H; Posadino, Anna Maria; Pintus, Gianfranco; Giordo, Roberta... more authors ... less authors ( Bentham Science Publisher , 2022 , Article Review)Neurodegenerative disorders include neurological conditions that affect nerve cells, causing the progressive loss of their functions and ultimately leading to loss of mobility, coordination, and mental functioning. The ...