تصفح حسب المؤلف "Zayed, Hatem"
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Anticancer Activity of Guggulsterone in Human Leukemic Cells
Younes, Salma Nagy Mahmoud Zaky (2020 , Master Thesis)Leukemia is a group of blood cancers that is characterized by the uncontrolled proliferation of hematopoietic cells and their progressive accumulation within the bone marrow (BM) and secondary lymphoid tissues. The main ... -
An Arab registry for type 1 diabetes: global benefits for type 1 diabetes patients
Zayed, Hatem; Ouhtit, Allal; El Bekay, Rajaa ( Taylor & Francis , 2016 , Article)BACKGROUND: The Arab world encompasses twenty-two Arabic-speaking countries, where the rate of consanguinity can exceed 50%. Type 1 diabetes (T1D), a chronic disorder that requires lifelong treatment, is believed to be ... -
Association between Soft Drink Consumption and Aggressive Behaviour among a Quarter Million Adolescents from 64 Countries Based on the Global School-Based Student Health Survey (GSHS)
Shi, Zumin; Malki, Ahmed; Abdel-Salam, Abdel-Salam; Liu, Jianghong; Zayed, Hatem ( MDPI , 2020 , Article)Soft drink consumption has become a significant public health concern that is associated with various adverse health outcomes.We aim to examine the association between soft drink consumption and aggressive behavior among ... -
Association of single nucleotide polymorphisms with dyslipidemia and risk of metabolic disorders in the State of Qatar
Al-Sharshani, Dalal; Velayutham, Dinesh; Samara, Muthanna; Gazal, Reham; Al Haj Zen, Ayman; Ismail, Mohamed A.; Ahmed, Mahmoud; Nasrallah, Gheyath; Younes, Salma; Rizk, Nasser; Hammuda, Sara; Qoronfleh, M. Walid; Farrell, Thomas; Zayed, Hatem; Abdulrouf, Palli Valapila; AlDweik, Manar; Silang, John Paul Ben; Rahhal, Alaa; Al-Jurf, Rana; Mahfouz, Ahmed; Salam, Amar; Al Rifai, Hilal; Al-Dewik, Nader I.... more authors ... less authors ( Wiley-Blackwell , 2023 , Article)Background: Dyslipidemia is recognized as one of the risk factors of cardiovascular diseases (CVDs), type 2 diabetes mellitus (T2DM), and non-alcoholic fatty liver disease (NAFLD). Objective: The study aimed to investigate ... -
Bioinformatics investigation on blood-based gene expressions of Alzheimer's disease revealed ORAI2 gene biomarker susceptibility: An explainable artificial intelligence-based approach
Sekaran, Karthik; Alsamman, Alsamman M.; George Priya Doss, C.; Zayed, Hatem ( Springer , 2023 , Article)The progressive, chronic nature of Alzheimer's disease (AD), a form of dementia, defaces the adulthood of elderly individuals. The pathogenesis of the condition is primarily unascertained, turning the treatment efficacy ... -
Chapter Four Controlling cell proliferation by targeting cyclin-dependent kinase 6 using drug repurposing approach
N., Madhana Priya; Balasundaram, Ambritha; Sidharth Kumar, N.; Udhaya Kumar, S.; Thirumal Kumar, D.; Magesh, R.; Zayed, Hatem; George Priya Doss, C.... more authors ... less authors ( Elsevier , 2023 , Book chapter)Cyclin-dependent kinase 6 (CDK6) is an essential kinase in cell cycle progression, which is a viable target for inhibitors in various malignancies, including breast cancer. This study aimed to virtually screen efficient ... -
Chapter Three Elucidating the mechanism of antimicrobial resistance in Mycobacterium tuberculosis using gene interaction networks
Keerthana, G.; Vasudevan, Karthick; Dey, Hrituraj; Kausar, Tasmia; Udhaya Kumar, S.; Thirumal Kumar, D.; Zayed, Hatem; George Priya Doss, C.... more authors ... less authors ( Elsevier , 2023 , Book chapter)Antimicrobial resistance (AMR) in microorganisms is an urgent global health threat. AMR of Mycobacterium tuberculosis is associated with significant morbidity and mortality. It is of great importance to underpin the ... -
ChatGPT’s scorecard after the performance in a series of tests conducted at the multi-country level: A pattern of responses of generative artificial intelligence or large language models
Manojit, Bhattacharya; Pal, Soumen; Chatterjee, Srijan; Alshammari, Abdulrahman; Albekairi, Thamer H.; Jagga, Supriya; Ige Ohimain, Elijah; Zayed, Hatem; Byrareddy, Siddappa N.; Lee, Sang-Soo; Wen, Zhi-Hong; Agoramoorthy, Govindasamy; Bhattacharya, Prosun; Chakraborty, Chiranjib... more authors ... less authors ( Elsevier , 2024 , Article)Recently, researchers have shown concern about the ChatGPT-derived answers. Here, we conducted a series of tests using ChatGPT by individual researcher at multi-country level to understand the pattern of its answer accuracy, ... -
Comparative computational assessment of the pathogenicity of mutations in the Aspartoacylase enzyme
George Priya Doss, C.; Zayed, Hatem ( Springer US , 2017 , Article)Aspartoacylase (ASPA) is a zinc-dependent abundant enzyme in the brain, which catalyzes the conversion of N-acetyl aspartate (NAA) into acetate and aspartate. Mutations in the ASPA gene are associated with the development ... -
Correction to: Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance (Molecular Cancer, (2020), 19, 1, (57), 10.1186/s12943-020-01175-9)
Bhat, Ajaz A.; Younes, Salma N.; Raza, Syed Shadab; Zarif, Lubna; Nisar, Sabah; Ahmed, Ikhlak; Mir, Rashid; Kumar, Sachin; Sharawat, Surender K.; Hashem, Sheema; Elfaki, Imadeldin; Kulinski, Michal; Kuttikrishnan, Shilpa; Prabhu, Kirti S.; Khan, Abdul Q.; Yadav, Santosh K.; El-Rifai, Wael; Zargar, Mohammad A.; Zayed, Hatem; Haris, Mohammad; Uddin, Shahab... more authors ... less authors ( BMC , 2020 , Other)Following the publication of the original article [1], authors have noticed that one of the authors, Syed Shadab Raza, was missing in the Authors’ Contributions section. Please see below updated section. -
Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach
P., Sneha; D., Thirumal Kumar; C., George Priya Doss; R., Siva; Zayed, Hatem ( Plos One , 2017 , Article)Maturity-onset diabetes of the young type 3 (MODY3) is a non-ketotic form of diabetes associated with poor insulin secretion. Over the past years, several studies have reported the association of missense mutations in the ... -
Effect of Resveratrol on Pregnancy, Prenatal Complications and Pregnancy-Associated Structure Alterations.
Ramli, Iman; Posadino, Anna Maria; Giordo, Roberta; Fenu, Grazia; Fardoun, Manal; Iratni, Rabah; Eid, Ali H; Zayed, Hatem; Pintus, Gianfranco... more authors ... less authors ( MDPI , 2023 , Article Review)Adverse pregnancy outcomes are considered significant health risks for pregnant women and their offspring during pregnancy and throughout their lifespan. These outcomes lead to a perturbated in-utero environment that impacts ... -
Enhanced Identification of Transcriptional Enhancers Provides Mechanistic Insights into Diseases.
Murakawa, Y; Yoshihara, M; Kawaji, H.; Nishikawa, M; Zayed, Hatem; Suzuki H, Fantom Consortium, Hayashizaki Y.... more authors ... less authors ( Cell Press , 2016 , Article)Enhancers are distal cis-regulatory DNA elements that increase the expression of target genes. Various experimental and computational approaches including chromatin signature profiling have been developed to predict enhancers ... -
Exome sequence analysis of rare frequency variants in Late-Onset Alzheimer Disease
Sundarrajan, Sudharsana; Venkatesan, Arthi; Kumar S, Udhaya; Gopikrishnan, Mohanraj; Tayubi, Iftikhar Aslam; Aditya, M.; Siddaiah, Gowrishankar Bychapur; George Priya Doss, C.; Zayed, Hatem... more authors ... less authors ( Springer Nature , 2023 , Article)Alzheimer disease (AD) is a leading cause of dementia in elderly patients who continue to live between 3 and 11 years of diagnosis. A steep rise in AD incidents is observed in the elderly population in East-Asian countries. ... -
An extensive computational approach to analyze and characterize the functional mutations in the galactose-1-phosphate uridyl transferase (GALT) protein responsible for classical galactosemia
S, Udhaya Kumar; D, Thirumal Kumar; R, Siva; C, George Priya Doss; Zayed, Hatem ( Elsevier , 2019 , Article)Type I galactosemia is a very rare autosomal recessive genetic metabolic disorder that occurs because of the mutations present in the galactose-1-phosphate uridyl transferase (GALT) gene, resulting in a deficiency of the ... -
Genetic Epidemiology of Glucose-6-Dehydrogenase Deficiency in the Arab World
Doss, C. George Priya; Alasmar, Dima R.; Bux, Reem I.; Sneha, P.; Bakhsh, Fadheela Dad; Al-Azwani, Iman; El Bekay, Rajaa; Zayed, Hatem... more authors ... less authors ( Nature Publishing Group , 2016 , Article)A systematic search was implemented using four literature databases (PubMed, Embase, Science Direct and Web of Science) to capture all the causative mutations of Glucose-6-phosphate dehydrogenase (G6PD) deficiency (G6PDD) ... -
Identification of dysregulated canonical pathways associated with pathogenesis and progression of Amyotrophic Lateral Sclerosis—An integrated bioinformatics approach
Datta, Ankur; Udhaya Kumar, S.; D'costa, Maria; Bothe, Anusha; Thirumal Kumar, D.; Zayed, Hatem; George Priya Doss, C.... more authors ... less authors ( Elsevier , 2023 , Article)The mechanisms responsible for the pathogenesis and progression of Amyotrophic Lateral Sclerosis (ALS) remain poorly understood, making the diagnosis of ALS challenging. We aimed to find the novel gene biomarkers via ... -
Identification of potential circadian genes and associated pathways in colorectal cancer progression and prognosis using microarray gene expression analysis
S., Sri Hari; G., Keerthana; Dey, Hrituraj; Sangoji, Rahul V.; Thirumal Kumar, D.; Zayed, Hatem; Vasudevan, Karthick; George Priya Doss, C.... more authors ... less authors ( Elsevier , 2023 , Book chapter)Colorectal cancer (CRC) is third cancer causing death in the world. CRC is associated with disrupting the circadian rhythm (CR), closely associating the CRC progression and the dysregulation of genes involved in the ... -
The Implication of Mechanistic Approaches and the Role of the Microbiome in Polycystic Ovary Syndrome (PCOS): A Review
Mukherjee, Anirban Goutam; Wanjari, Uddesh Ramesh; Kannampuzha, Sandra; Murali, Reshma; Namachivayam, Arunraj; Ganesan, Raja; Dey, Abhijit; Babu, Achsha; Renu, Kaviyarasi; Vellingiri, Balachandar; Ramanathan, Gnanasambandan; George Priya Doss, C.; Elsherbiny, Nehal; Elsherbini, Amira M.; Alsamman, Alsamman M.; Zayed, Hatem; Gopalakrishnan, Abilash Valsala... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)As a complex endocrine and metabolic condition, polycystic ovarian syndrome (PCOS) affects women’s reproductive health. These common symptoms include hirsutism, hyperandrogenism, ovulatory dysfunction, irregular menstruation, ... -
Implications and theragnostic potentials of circular RNAs in rheumatic diseases
Alaa Ahmed, Abbas; Abdulkader, Hadil Adnan; Giordo, Roberta; Ashour, Hossam M.; Erre, Gian Luca; Pintus, Gianfranco; Zayed, Hatem... more authors ... less authors ( Elsevier , 2023 , Article Review)Circular RNAs (circRNAs), a class of non-coding RNAs (ncRNAs), are highly stable and ubiquitous molecules that exhibit tissue-specific expression. Accumulating evidence has shown that aberrant expression of circRNAs can ...