Browsing by Author "Al-Mansoori, Layla"
Now showing items 1-10 of 10
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Age and sport intensity-dependent changes in cytokines and telomere length in elite athletes
Sellami, Maha; Al-Muraikhy, Shamma; Al-Jaber, Hend; Al-Amri, Hadaia; Al-Mansoori, Layla; Mazloum, Nayef A.; Donati, Francesco; Botre, Francesco; Elrayess, Mohamed A.... more authors ... less authors ( MDPI , 2021 , Article Review)Background: Exercise-associated immune response plays a crucial role in the aging process. The aim of this study is to investigate the effect of sport intensity on cytokine levels, oxidative stress markers and telomere ... -
Assessment of Serum Cytokines and Oxidative Stress Markers in Elite Athletes Reveals Unique Profiles Associated With Different Sport Disciplines
Sohail, Muhammad U.; Al-Mansoori, Layla; Al-Jaber, Hend; Georgakopoulos, Costas; Donati, Francesco; Botrè, Francesco; Sellami, Maha; Elrayess, Mohamed A.... more authors ... less authors ( Frontiers Media , 2020 , Article)© Copyright © 2020 Sohail, Al-Mansoori, Al-Jaber, Georgakopoulos, Donati, Botrè, Sellami and Elrayess. Objectives: Circulating cytokines and oxidative stress markers vary in response to different exercise regimens. This ... -
Effect of sera from elite athletes on cytokine secretion and insulin signaling in preadipocytes and skeletal muscle cells
Alheidous, Sara; Al-Muraikhy, Shamma; Rizk, Nasser; Sellami, Maha; Donati, Francesco; Botre, Francesco; Al-Mansoori, Layla; Elrayess, Mohamed A.... more authors ... less authors ( Frontiers Media , 2022 , Article)Introduction: The immunomodulatory effect of physical activity can impact insulin signaling differentially in adipose tissues and skeletal muscle cells, depending on sport intensity. In this study, the effect of serum from ... -
GATA-3 as a potential therapeutic target for insulin resistance and type 2 diabetes mellitus.
Al-Jaber, Hend; Al-Mansoori, Layla; Elrayess, Mohamed A ( PubMed Central , 2020 , Article Review)Impaired adipogenesis plays an important role in the development of obesity-associated insulin resistance and type 2 diabetes as it leads to ectopic fat deposition. The anti-adipogenic transcription factor GATA-3 was ... -
In vitro studies on CNGRC-CPG2 fusion proteins for ligand-directed enzyme prodrug therapy for targeted cancer therapy
Al-Mansoori, Layla; Bashraheel, Sara S; Qahtani, Alanod D Al; O'Connor, C David; Elsinga, Philip; Goda, Sayed K... more authors ... less authors ( Impact Journals , 2020 , Article)The sequence asparagine-glycine arginine (NGR), flanked by Cysteine (Cys) residues so as to form a disulfide-bridge (CNGRC), has previously been found to target and bind specifically to aminopeptidase N (APN), which is ... -
Metabolomics of lean/overweight insulin resistant females reveals alterations in steroids and fatty acids.
Diboun, Ilhame; Al-Mansoori, Layla; Al-Jaber, Hend; Albagha, Omar; Elrayess, Mohamed A ( Endocrine Society , 2020 , Article)The global diabetes epidemic is largely attributed to obesity-triggered metabolic syndrome. However, the impact of insulin resistance (IR) prior to obesity on the high prevalence of diabetes and the molecular mediators ... -
Production of Long-Acting CNGRC–CPG2 Fusion Proteins: New Derivatives to Overcome Drug Immunogenicity of Ligand-Directed Enzyme Prodrug Therapy for Targeted Cancer Treatment
Al-Mansoori, Layla; Al Qahtani, Alanod D.; Elsinga, Philip; Goda, Sayed K. ( SAGE , 2021 , Article)Objectives: Aminopeptidase N (APN) is an enzyme highly expressed in metastatic cancers and could be used in targeted cancer therapy. Our previous work showed the successful construction of CNGRC–carboxypeptidase G2 (CPG2) ... -
Role of Inflammatory Cytokines, Growth Factors and Adipokines in Adipogenesis and Insulin Resistance
Al-Mansoori, Layla; Al-Jaber, Hend; Prince, Mohammad Shoaib; Elrayess, Mohamed A. ( Springer , 2021 , Article Review)Obesity, manifested by increased adiposity, represents a main cause of morbidity in the developed countries, causing increased risk of insulin resistance and type 2 diabetes mellitus. Recruitment of macrophages and activation ... -
Suppression of GATA-3 increases adipogenesis, reduces inflammation and improves insulin sensitivity in 3T3L-1 preadipocytes
Al-Mansoori, Layla; Al-Jaber, Hend; Madani, Aisha Y.; Mazloum, Nayef A.; Agouni, Abdelali; Ramanjaneya, Manjunath; Abou-Samra, Abdul Badi; Elrayess, Mohamed A.... more authors ... less authors ( Elsevier , 2020 , Article)© 2020 Impaired adipogenesis plays an important role in the development of obesity-associated insulin resistance and type 2 diabetes. Adipose tissue inflammation is a crucial mediator of this process. GATA-3 plays important ... -
The Role of GATA3 in Adipogenesis & Insulin Resistance
Al-Jaber, Hend Sultan; Al-Mansoori, Layla Jadea; ElRayess, Mohamed Aghar ( Qatar University Press , 2020 , Poster)Background: Impaired adipogenesis plays an important role in the development of obesity-associated insulin resistance and type 2 diabetes. Adipose tissue inflammation is a crucial mediator of this process. In hyperglycemia, ...