Browsing by Author "Pozzoli, Giacomo"
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Aspirin inhibits cancer stem cells properties and growth of glioblastoma multiforme through Rb1 pathway modulation.
Pozzoli, Giacomo; Marei, Hany E; Althani, Asma; Boninsegna, Alma; Casalbore, Patrizia; Marlier, Lionel N J L; Lanzilli, Giulia; Zonfrillo, Manuela; Petrucci, Giovanna; Rocca, Bianca; Navarra, Pierluigi; Sgambato, Alessandro; Cenciarelli, Carlo... more authors ... less authors ( Wiley , 2019 , Article)Several clinical studies indicated that the daily use of aspirin or acetylsalicylic acid reduces the cancer risk via cyclooxygenases (Cox-1 and Cox-2) inhibition. In addition, aspirin-induced Cox-dependent and -independent ... -
Cancer immunotherapy with immune checkpoint inhibitors (ICIs): potential, mechanisms of resistance, and strategies for reinvigorating T cell responsiveness when resistance is acquired
Marei, Hany E.; Hasan, Anwarul; Pozzoli, Giacomo; Cenciarelli, Carlo ( BioMed Central Ltd , 2023 , Article Review)Cancer is still the leading cause of death globally. The approval of the therapeutic use of monoclonal antibodies against immune checkpoint molecules, notably those that target the proteins PD-1 and PD-L1, has changed the ... -
Pandemic COVID-19 caused by SARS-CoV-2: genetic structure, vaccination, and therapeutic approaches
Marei, Hany E.; Althani, Asmaa; Afifi, Nahla; Pozzoli, Giacomo; Caceci, Thomas; Angelini, Franco; Cenciarelli, Carlo... more authors ... less authors ( Springer , 2021 , Article Review)We give a summary of SARS-genetic CoV-2’s structure and evolution, as well as current attempts to develop efficient vaccine and treatment methods for SARS-CoV-2 infection, in this article. Most therapeutic strategies are ...