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    Browsing by Author "Yassine, Hadi M."

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        Addressing bias in the definition of SARS-CoV-2 reinfection: implications for underestimation 

        Chemaitelly, Hiam; Ayoub, Houssein H.; Tang, Patrick; Yassine, Hadi M.; Al Thani, Asmaa A.; Hasan, Mohammad R.; Coyle, Peter; Al-Kanaani, Zaina; Al-Kuwari, Einas; Jeremijenko, Andrew; Kaleeckal, Anvar Hassan; Latif, Ali Nizar; Shaik, Riyazuddin Mohammad; Abdul-Rahim, Hanan F.; Nasrallah, Gheyath K.; Al-Kuwari, Mohamed Ghaith; Butt, Adeel A.; Al-Romaihi, Hamad Eid; Al-Thani, Mohamed H.; Al-Khal, Abdullatif; Bertollini, Roberto; Abu-Raddad, Laith J.... more authors ... less authors ( Frontiers Media , 2024 , Article)
        Introduction: Reinfections are increasingly becoming a feature in the epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, accurately defining reinfection poses methodological ...
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        Assessment of the Risk of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Reinfection in an Intense Reexposure Setting 

        Abu-Raddad, Laith J.; Chemaitelly, Hiam; Malek, Joel A.; Ahmed, Ayeda A.; Mohamoud, Yasmin A.; Younuskunju, Shameem; Ayoub, Houssein H.; Al Kanaani, Zaina; Al Khal, Abdullatif; Al Kuwari, Einas; Butt, Adeel A.; Coyle, Peter; Jeremijenko, Andrew; Kaleeckal, Anvar Hassan; Latif, Ali Nizar; Shaik, Riyazuddin Mohammad; Abdul Rahim, Hanan F.; Yassine, Hadi M.; Al Kuwari, Mohamed G.; Al Romaihi, Hamad Eid; Al-Thani, Mohamed H.; Bertollini, Roberto... more authors ... less authors ( NLM (Medline) , 2021 , Article)
        BACKGROUND: Risk of reinfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is unknown. We assessed the risk and incidence rate of documented SARS-CoV-2 reinfection in a cohort of laboratory-confirmed ...
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        Associations of Vaccination and of Prior Infection with Positive PCR Test Results for SARS-CoV-2 in Airline Passengers Arriving in Qatar 

        Bertollini, Roberto; Chemaitelly, Hiam; Yassine, Hadi M.; Al-Thani, Mohamed H.; Al-Khal, Abdullatif; Abu-Raddad, Laith J.... more authors ... less authors ( American Medical Association , 2021 , Article)
        The SARS-CoV-2 pandemic has severely affected international travel. With efficacious COVID-19 vaccines available, Qatar implemented a pilot program between February 18 and April 26, 2021, to ease travel restrictions by ...
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        Biological Properties of SARS-CoV-2 Variants: Epidemiological Impact and Clinical Consequences 

        Hoteit, R.; Hoteit, Reem; Yassine, Hadi M. ( MDPI , 2022 , Article Review)
        Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a virus that belongs to the coronavirus family and is the cause of coronavirus disease 2019 (COVID-19). As of May 2022, it had caused more than 500 million ...
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        Bivalent mRNA-1273.214 vaccine effectiveness against SARS-CoV-2 omicron XBB* infections 

        Chemaitelly, Hiam; Ayoub, Houssein H.; AlMukdad, Sawsan; Faust, Jeremy S.; Tang, Patrick; Coyle, Peter; Yassine, Hadi M.; Al Thani, Asmaa A.; Al-Khatib, Hebah A.; Hasan, Mohammad R.; Al-Kanaani, Zaina; Al-Kuwari, Einas; Jeremijenko, Andrew; Kaleeckal, Anvar H.; Latif, Ali N.; Shaik, Riyazuddin M.; Abdul-Rahim, Hanan F.; Nasrallah, Gheyath K.; Al-Kuwari, Mohamed G.; Butt, Adeel A.; Al-Romaihi, Hamad E.; Al-Thani, Mohamed H.; Al-Khal, Abdullatif; Bertollini, Roberto; Abu-Raddad, Laith J.... more authors ... less authors (2023 , Article)
        In October of 2022, Qatar introduced COVID-19 bivalent vaccination for persons ≥ 12 years using the 50-μg mRNA-1273.214 vaccine combining SARS-CoV-2 ancestral and omicron BA.1 strains.1 We estimated this vaccine’s effectiveness ...
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        BNT162b2 antigen dose and SARS-CoV-2 omicron infection in adolescents 

        Chemaitelly, Hiam; Ayoub, Houssein H.; Coyle, Peter; Tang, Patrick; Yassine, Hadi M.; Al Thani, Asmaa A.; Al-Khatib, Hebah A.; Hasan, Mohammad R.; Al-Kanaani, Zaina; Al-Kuwari, Einas; Jeremijenko, Andrew; Kaleeckal, Anvar Hassan; Latif, Ali Nizar; Shaik, Riyazuddin Mohammad; Abdul-Rahim, Hanan F.; Nasrallah, Gheyath K.; Al-Kuwari, Mohamed Ghaith; Al-Romaihi, Hamad Eid; Butt, Adeel A.; Al-Thani, Mohamed H.; Al-Khal, Abdullatif; Bertollini, Roberto; Abu-Raddad, Laith J.... more authors ... less authors ( Elsevier , 2023 , Other)
        COVID-19 vaccine antigen dose might affect protection against SARS-CoV-2 infection,1, 2 but direct evidence to quantify this effect is absent. We conducted a matched, retrospective, cohort study using a regression ...
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        A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate 

        Geethakumari, Anupriya M; Sultana, Asfia; Fatima, Asma; Uddin, S M Nasir; Abdulhakim, Somaiya; Mohamed, Amera; Rahman, Samiha; Al-Buainain, Khaloud; Yassine, Hadi M; Khatib, Hebah A Al; Biswas, Kabir H... more authors ... less authors ( Elsevier , 2025 , Article)
        Here, we report the engineering of a Bioluminescence Resonance Energy Transfer (BRET)-based SARS-CoV-2 main protease (Mpro) biosensor containing the Mpro N-terminal autocleavage sequence in tandem and a nanobody that shows ...
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        Burden and disease pathogenesis of influenza and other respiratory viruses in diabetic patients 

        Swapna, Thomas; Ouhtit, Allal; Al Khatib, Hebah A.; Eid, Ali H.; Mathew, Shilu; Nasrallah, Gheyath K.; Emara, Mohamed M.; Al Maslamani, Muna A.; Yassine, Hadi M.... more authors ... less authors ( Elsevier , 2022 , Article Review)
        Over the past two decades, diabetes mellitus (DM) has been receiving increasing attention among autoimmune diseases. The prevalence of type 1 and type 2 diabetes has increased rapidly and has become one of the leading ...
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        Characterizing the effective reproduction number during the COVID-19 pandemic: Insights from Qatar's experience 

        Bsat, Raghid; Chemaitelly, Hiam; Coyle, Peter; Tang, Patrick; Hasan, Mohammad R.; Kanaani, Zaina Al; Kuwari, Einas Al; Butt, Adeel A.; Jeremijenko, Andrew; Kaleeckal, Anvar Hassan; Latif, Ali Nizar; Shaik, Riyazuddin Mohammad; Nasrallah, Gheyath K.; Benslimane, Fatiha M.; Khatib, Hebah A.Al; Yassine, Hadi M.; Kuwari, Mohamed G.Al; Romaihi, Hamad Eid Al; Al-Thani, Mohamed H.; Khal, Abdullatif Al; Bertollini, Roberto; Abu-Raddad, Laith J.; Ayoub, Houssein H.... more authors ... less authors ( Edinburgh University Global Health Society , 2022 , Article)
        Background The effective reproduction number, Rt, is a tool to track and understand pandemic dynamics. This investigation of Rt estimations was conducted to guide the national COVID-19 response in Qatar, from the onset of ...
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        Comparable antibody levels in heterologous and homologous mRNA COVID-19 vaccination, with superior neutralizing and IgA antibody responses in mRNA homologous boosting 

        Salma, Younes; Nicolai, Eleonora; Younes, Nadin; Pieri, Massimo; Bernardini, Sergio; Nizamuddin, Parveen B.; Al-Sadeq, Duaa W.; Daas, Hanin I.; Ismail, Ahmed; Yassine, Hadi M.; Abu-Raddad, Laith J.; Nasrallah, Gheyath K.... more authors ... less authors ( Elsevier , 2024 , Article)
        BackgroundPriming with two doses of AZD1222 (Oxford-AstraZeneca; ChAd) followed by a third mRNA vaccine boosting is considered in several countries, yet comparisons between heterologous and homologous booster efficacy ...
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        Comparative analysis of within-host diversity among vaccinated COVID-19 patients infected with different SARS-CoV-2 variants 

        Hebah A., Al-Khatib; Smatti, Maria K.; Ali, Fatma H.; Zedan, Hadeel T.; Thomas, Swapna; Ahmed, Muna N.; El-kahlout, Reham A.; Al Bader, Mashael A.; Elgakhlab, Dina; Coyle, Peter V.; Abu-Raddad, Laith J.; Al Thani, Asma A.; Yassine, Hadi M.... more authors ... less authors ( Elsevier , 2022 , Article)
        Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a rapidly evolving RNA virus that mutates within hosts and exists as viral quasispecies. Here, we evaluated the within-host diversity among vaccinated and ...
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        Comprehensive analysis of human coronavirus antibody responses in ICU and non-ICU COVID-19 patients reveals IgG3 against SARS-CoV-2 spike protein as a key biomarker of disease severity 

        Ali, Fatma H.; Gentilcore, Giusy; Al-Jighefee, Hadeel T.; Taleb, Sara Ahmad; Hssain, Ali Ait; Qotba, Hamda A.; Al Thani, Asmaa A.; Abu Raddad, Laith J.; Nasrallah, Gheyath K.; Grivel, Jean Charles; Yassine, Hadi M.... more authors ... less authors ( Microbiology Society , 2025 , Article)
        Introduction. Pre-existing immunity to human coronaviruses (HCoVs) may shape the immune response in COVID-19 patients. Increasing evidence suggests that immune cross-reactivity between SARS-CoV-2 and other coronaviruses ...
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        A Comprehensive Machine Learning Approach for COVID-19 Target Discovery in the Small-Molecule Metabolome 

        Sumon, Md Shaheenur Islam; Hossain, Md Sakib Abrar; Al-Sulaiti, Haya; Yassine, Hadi M.; Chowdhury, Muhammad E.H. ( Multidisciplinary Digital Publishing Institute (MDPI) , 2025 , Article)
        Background/Objectives: Respiratory viruses, including Influenza, RSV, and COVID-19, cause various respiratory infections. Distinguishing these viruses relies on diagnostic methods such as PCR testing. Challenges stem from ...
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        Computational screening of known broad-spectrum antiviral small organic molecules for potential influenza HA stem inhibitors. 

        Mathew, Shilu; Al Thani, Asmaa A; Yassine, Hadi M ( Public Library of Science , 2018 , Article)
        With the emergence of new influenza virus strains that are resistant to current inhibitors such as oseltamivir (anti-neuraminidase (NA)) and amantadine (anti-M2 proton channel), influenza A viruses continue to be a serious ...
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        Coronavirus Disease 2019 Disease Severity in Children Infected With the Omicron Variant 

        Butt, A.A.; Butt, Adeel A.; Dargham, Soha R.; Loka, Srusvin; Shaik, Riyazuddin M.; Chemaitelly, Hiam; Tang, Patrick; Hasan, Mohammad R.; Coyle, Peter V.; Yassine, Hadi M.; Al-Khatib, Hebah A.; Smatti, Maria K.; Kaleeckal, Anvar H.; Latif, Ali Nizar; Zaqout, Ahmed; Almaslamani, Muna A.; Al Khal, Abdullatif; Bertollini, Roberto; Abou-Samra, Abdul Badi; Abu-Raddad, Laith J.... more authors ... less authors ( NLM (Medline) , 2022 , Article)
        SHORT SUMMARY: Severe acute respiratory syndrome coronavirus 2 infection from the Omicron variant in children/adolescents is less severe than infection from the Delta variant. Those 6 to <18 years also have less severe ...
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        COVID-19 Disease Severity in Persons Infected with Omicron BA.1 and BA.2 Sublineages and Association with Vaccination Status 

        Butt, Adeel A.; Dargham, Soha R.; Coyle, Peter; Yassine, Hadi M.; Al-Khal, Abdullatif; Abou-Samra, Abdul Badi; Abu-Raddad, Laith J.... more authors ... less authors ( American Medical Association , 2022 , Article)
        Infection with the SARS-CoV-2 Omicron variant is associated with less severe disease compared with the Delta variant.1-3 Two main Omicron sublineages—BA.1 and BA.2—have variable geographic distribution. In Qatar, BA.1 was ...
      • Covid-19 Vaccine Protection among Children and Adolescents in Qatar. 

        Chemaitelly, Hiam; AlMukdad, Sawsan; Ayoub, Houssein H; Altarawneh, Heba N; Coyle, Peter; Tang, Patrick; Yassine, Hadi M; Al-Khatib, Hebah A; Smatti, Maria K; Hasan, Mohammad R; Al-Kanaani, Zaina; Al-Kuwari, Einas; Jeremijenko, Andrew; Kaleeckal, Anvar H; Latif, Ali N; Shaik, Riyazuddin M; Abdul-Rahim, Hanan F; Nasrallah, Gheyath K; Al-Kuwari, Mohamed G; Al-Romaihi, Hamad E; Butt, Adeel A; Al-Thani, Mohamed H; Al-Khal, Abdullatif; Bertollini, Roberto; Abu-Raddad, Laith J... more authors ... less authors ( Massachusetts Medical Society , 2022 , Article)
        The BNT162b2 vaccine against coronavirus disease 2019 (Covid-19) has been authorized for use in children 5 to 11 years of age and adolescents 12 to 17 years of age but in different antigen doses. We assessed the real-world ...
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        The Current Status of Cytomegalovirus (CMV) Prevalence in the MENA region: a systematic review 

        Al Mana, Hassan; Yassine, Hadi M.; Youne, Nadin N.; Al-Mohannadi, Anjud; Al-Sadeq, Duaa W.; Alhababi, Dalal; Nasrallah, Gheyath K.... more authors ... less authors ( MDPI , 2019 , Article)
        Human cytomegalovirus (CMV) is a highly prevalent herpesvirus worldwide. According to the Centers for Disease Control and Prevention (CDC) and the World Health Organization (WHO), CMV infects people of all ages, and by ...
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        Demographics and Epidemiology of Hepatitis B in the State of Qatar: A Five-Year Surveillance-Based Incidence Study 

        Al Romaihi, Hamad E.; Ganesan, Nandakumar; Farag, Elmoubasher A.; Smatti, Maria K.; Nasrallah, Gheyath K.; Himatt, Sayed M.; Derbala, Moutaz F.; Alshamali, Maha; Mahadoon, Lylu K.; Khogali, Hayat S.; Sallam, Mohamed; Al Thani, Asmaa A.; Al Thani, Mohammed; Al Kaabi, Saad; Yassine, Hadi M.... more authors ... less authors ( MDPI , 2019 , Article)
        Background: Expatriates represent >80% of Qatar’s population, mostly arriving from countries in Africa and Asia that are endemic with many diseases. This increases the risk for introducing new pathogens into the country ...
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        Detection of Antinuclear Antibodies Targeting Intracellular Signal Transduction, Metabolism, Apoptotic Processes and Cell Death in Critical COVID-19 Patients 

        Nasarallah, Gheyath K.; Fakhroo, Aisha D.; Khan, Taushif; Cyprian, Farhan S.; Al Ali, Fatima; Ata, Manar M.A.; Taleb, Sara; Zedan, Hadeel T.; Al-Sadeq, Duaa W.; Amanullah, Fathima H.; Hssain, Ali A.; Eid, Ali H.; Abu-Raddad, Laith J.; Al-Khal, Abdullatif; Al Thani, Asmaa A.; Marr, Nico; Yassine, Hadi M.... more authors ... less authors ( Universita Cattolica del Sacro Cuore , 2022 , Article)
        Background and Objectives: The heterogeneity of the coronavirus disease of 2019 (COVID-19) lies within its diverse symptoms and severity, ranging from mild to lethal. Acute respiratory distress syndrome (ARDS) is a leading ...

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