Browsing by Author "Nasrallah, Gheyath K."

Now showing items 1-20 of 199

    • Accre 8 emerging point of care CLIA system for vitamin B12 assessment compared with three established assays 

      Trad, Farah M.; AlHamad, Tasneem; Younes, Nadin; Abunasser, Shaden; Younes, Salma; ... more authors ( Nature Research , 2025 , Article)
      Accurate Vitamin B12 (Vit B12) quantification is essential for diagnosing deficiencies linked to neurological and hematological disorders. The Accre 8 Point-of-Care (POC) Chemiluminescent Immunoassay (CLIA) system offers ...

    • Addressing bias in the definition of SARS-CoV-2 reinfection: implications for underestimation 

      Chemaitelly, Hiam; Ayoub, Houssein H.; Tang, Patrick; Yassine, Hadi M.; Al Thani, Asmaa A.; ... more authors ( Frontiers Media , 2024 , Article)
      Introduction: Reinfections are increasingly becoming a feature in the epidemiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, accurately defining reinfection poses methodological ...

    • Adipose tissue dysfunction in cancer cachexia 

      Daas, Sahar I; Rizeq, Balsam R; Nasrallah, Gheyath K ( Wiley Periodicals, Inc. , 2018 , Article)
      Cancer cachexia is a complex disorder that is driven by inflammation and metabolic imbalances, resulting in extreme weight loss. Adipose tissue, a main player in cancer cachexia, is an essential metabolic and secretory ...

    • AEO-7 surfactant is “super toxic” and induces severe cardiac, liver and locomotion damage in zebrafish embryos 

      Al-Asmakh, Maha; Majdalawieh, Amin F.; Abdullah, Aboubakr M.; Younes, Nadin; Da’as, Sahar I.; ... more authors ( SpringerOpen , 2020 , Article)
      © 2020, The Author(s). Background: Fatty alcohol polyoxyethylene ether-7 (AEO-7), a non-ionic surfactant, has recently been receiving extensive attention from the ocean pipeline industry for its ability to inhibit corrosion. ...

    • An updated overview of cyanidins for chemoprevention and cancer therapy 

      Posadino, Anna Maria; Giordo, Roberta; Ramli, Iman; Zayed, Hatem; Nasrallah, Gheyath K.; ... more authors ( Elsevier , 2023 , Article Review)
      Anthocyanins are colored polyphenolic compounds that belong to the flavonoids family and are largely present in many vegetables and fruits. They have been used in traditional medicine in many cultures for a long time. The ...

    • Analytic comparison between three high-throughput commercial SARS-CoV-2 antibody assays reveals minor discrepancies in a high-incidence population 

      Nasrallah, Gheyath K; Dargham, Soha R; Shurrab, Farah; Al-Sadeq, Duaa W; Al-Jighefee, Hadeel; ... more authors ( Nature Research , 2021 , Article)
      Performance of three automated commercial serological IgG-based assays was investigated for assessing SARS-CoV-2 "ever" (past or current) infection in a population-based sample in a high exposure setting. PCR and serological ...

    • Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa 

      Majdalawieh, Amin F.; Fayyad, Muneera W.; Nasrallah, Gheyath K. ( Taylor & Francis , 2017 , Article)
      Over the past two decades, studies have documented the wide-range anti-cancer effects of Nigella sativa, known as black seed or black cumin. Thymoquinone (TQ), its major active ingredient, has also been extensively studied ...

    • Antibody Response to SARS-CoV-2: A Cohort Study in Qatar's Primary Care Settings. 

      Syed, Mohamed Ahmed; Al Nuaimi, Ahmed Sameer; Nasrallah, Gheyath K; Althani, Asmaa Ali J F; Zainel, Abduljaleel Abdullatif; ... more authors ( SAGE Publications , 2021 , Article)
      Globally, countries are rolling out Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) quarantine policies and vaccination programs. Research studies are needed in helping understand the likelihood of acquired ...

    • Antibody-dependent enhancement (ADE) of SARS-CoV-2 in patients exposed to MERS-CoV and SARS-CoV-2 antigens 

      Thomas, Swapna; Smatti, Maria K.; Alsulaiti, Haya; Zedan, Hadeel T.; Eid, Ali H.; ... more authors ( Wiley , 2024 , Article)
      This study evaluated the potential for antibody-dependent enhancement (ADE) in serum samples from patients exposed to Middle East respiratory syndrome coronavirus (MERS-CoV). Furthermore, we evaluated the effect of severe ...

    • Antibody-dependent enhancement of SARS-CoV-2, the impact of variants and vaccination 

      Thomas, Swapna; Smatti, Maria K.; Mohammad AlKhatib, Hebah Atef; Tayyar, Yaman; Nizar, Muna; ... more authors ( Taylor and Francis Group , 2025 , Article)
      This study characterized antibody-dependent enhancement (ADE) in serum samples from individuals exposed to SARS-CoV-2 via infection or vaccination and evaluated its association with SARS-CoV-2 variants (Wuhan and Omicron), ...

    • Antimicrobial Resistance of Commensal Escherichia coli Isolated from Food Animals in Qatar 

      Alhababi, Dalal A; Eltai, Nahla O; Nasrallah, Gheyath K; Farg, Elmoubasher A; Al Thani, Asmaa A; ... more authors ( Mary Ann Liebert , 2020 , Article)
      This study aims at evaluating the phenotypic and genotypic antimicrobial resistance (AMR) patterns of 18 clinically relevant antibiotics in food animals in Qatar. Fecal samples from camels, cattle, and pigeons (300) were ...

    • Arrhythmogenic calmodulin E105A mutation alters cardiac RyR2 regulation leading to cardiac dysfunction in zebrafish 

      Da'as, Sahar I; Thanassoulas, Angelos; Calver, Brian L; Beck, Konrad; Salem, Rola; ... more authors ( Wiley , 2019 , Article)
      Calmodulin (CaM) is a universal calcium (Ca )-binding messenger that regulates many vital cellular events. In cardiac muscle, CaM associates with ryanodine receptor 2 (RyR2) and regulates excitation-contraction coupling. ...

    • Assessing healthy vaccinee effect in COVID-19 vaccine effectiveness studies: a national cohort study in Qatar. 

      Chemaitelly, Hiam; Ayoub, Houssein H; Coyle, Peter; Tang, Patrick; Hasan, Mohammad R; ... more authors ( National Center for Biotechnology Information , 2025 , Article)
      This study investigated the presence of the healthy vaccinee effect-the imbalance in health status between vaccinated and unvaccinated individuals-in two rigorously conducted COVID-19 vaccine effectiveness studies involving ...

    • Assessment of Broadly Reactive Responses in Patients With MERS-CoV Infection and SARS-CoV-2 Vaccination 

      Zedan, Hadeel T.; Smatti, Maria K.; Thomas, Swapna; Nasrallah, Gheyath K.; Afifi, Nahla M.; ... more authors ( American Medical Association , 2023 , Article)
      Importance: In the ongoing COVID-19 pandemic, there remain unanswered questions regarding the nature and importance of the humoral immune response against other coronaviruses. Although coinfection of the Middle East ...

    • Assessment of the Neutralizing Antibody Response of BNT162b2 and mRNA-1273 SARS-CoV-2 Vaccines in Naïve and Previously Infected Individuals: A Comparative Study 

      Shurrab, Farah M.; Al-Sadeq, Duaa W.; Abou-Saleh, Haissam; Al-Dewik, Nader; Elsharafi, Amira E.; ... more authors ( MDPI , 2022 , Report)
      The currently authorized mRNA COVID-19 vaccines, Pfizer-BNT162b2 and Moderna-mRNA-1273, offer great promise for reducing the spread of the COVID-19 by generating protective immunity against SARS-CoV-2. Recently, it was ...

    • Association of Prior SARS-CoV-2 Infection With Risk of Breakthrough Infection Following mRNA Vaccination in Qatar. 

      Abu-Raddad, Laith J; Chemaitelly, Hiam; Ayoub, Houssein H; Yassine, Hadi M; Benslimane, Fatiha M; ... more authors ( American Medical Association , 2021 , Article)
      The effect of prior SARS-CoV-2 infection on vaccine protection remains poorly understood. To assess protection from SARS-CoV-2 breakthrough infection after mRNA vaccination among persons with vs without prior SARS-CoV-2 ...

    • Author Correction: Global burden of chikungunya virus infections and the potential benefit of vaccination campaigns (Nature Medicine, (2025), 31, 7, (2342-2349), 10.1038/s41591-025-03703-w) 

      Ribeiro dos Santos, Gabriel; Jawed, Fariha; Mukandavire, Christinah; Deol, Arminder; Scarponi, Danny; ... more authors ( Nature Research , 2025 , Article)
      Correction to: Nature Medicinehttps://doi.org/10.1038/s41591-025-03703-w, published online 10 June 2025. In the version of the article initially published, our code regarding the calculation of Years of Life lived with a ...

    • Biochemical and structural impact of two novel missense mutations in cystathionine β-synthase gene associated with homocystinuria 

      Al-Sadeq, Duaa W.; Conter, Carolina; Thanassoulas, Angelos; Al-Dewik, Nader; Safieh-Garabedian, Bared; ... more authors ( Portland Press Ltd , 2024 , Article)
      Homocystinuria is a rare disease caused by mutations in the CBS gene that results in a deficiency of cystathionine β-synthase (CBS). CBS is an essential pyridoxal 50-phosphate (PLP)-dependent enzyme in the transsulfuration ...

    • Bivalent mRNA-1273.214 vaccine effectiveness against SARS-CoV-2 omicron XBB* infections 

      Chemaitelly, Hiam; Ayoub, Houssein H.; AlMukdad, Sawsan; Faust, Jeremy S.; Tang, Patrick; ... more authors (2023 , Article)
      In October of 2022, Qatar introduced COVID-19 bivalent vaccination for persons ≥ 12 years using the 50-μg mRNA-1273.214 vaccine combining SARS-CoV-2 ancestral and omicron BA.1 strains.1 We estimated this vaccine’s effectiveness ...

    • BNT162b2 and mRNA-1273 COVID-19 vaccine effectiveness against the SARS-CoV-2 Delta variant in Qatar. 

      Tang, Patrick; Hasan, Mohammad R; Chemaitelly, Hiam; Yassine, Hadi M; Benslimane, Fatiha M; ... more authors ( Nature Researc , 2021 , Article)
      With the global expansion of the highly transmissible SARS-CoV-2 Delta (B.1.617.2) variant, we conducted a matched test-negative case-control study to assess the real-world effectiveness of COVID-19 messenger RNA vaccines ...