Browsing by Author "Gadeau, Alain Pierre"
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Crosstalk between Sodium–Glucose Cotransporter Inhibitors and Sodium–Hydrogen Exchanger 1 and 3 in Cardiometabolic Diseases
Al-Shamasi, Al-Anood; Elkaffash, Rozina; Mohamed, Meram; Rayan, Menatallah; Al-Khater, Dhabya; Gadeau, Alain-Pierre; Ahmed, Rashid; Hasan, Anwarul; Eldassouki, Hussein; Yalcin, Huseyin Cagatay; Abdul-Ghani, Muhammad; Mraiche, Fatima... more authors ... less authors ( MDPI , 2021 , Article)Abnormality in glucose homeostasis due to hyperglycemia or insulin resistance is the hallmark of type 2 diabetes mellitus (T2DM). These metabolic abnormalities in T2DM lead to cellular dysfunction and the development of ... -
Empagliflozin inhibits angiotensin II-induced hypertrophy in H9c2 cardiomyoblasts through inhibition of NHE1 expression
Abdulrahman, Nabeel; Ibrahim, Meram; Joseph, Jensa Mariam; Elkoubatry, Hanan Mahmoud; Al-Shamasi, Al Anood; Rayan, Menatallah; Gadeau, Alain Pierre; Ahmed, Rashid; Eldassouki, Hussein; Hasan, Anwarul; Mraiche, Fatima... more authors ... less authors ( Springer , 2022 , Article)Diabetes mellitus (DM)-induced cardiac morbidities have been the leading cause of death among diabetic patients. Recently, sodium-glucose cotransporter-2 (SGLT-2) inhibitors including empagliflozin (EMPA), which have been ... -
Evaluating the effects of sodium glucose co-transporter -2 inhibitors from a renin–angiotensin–aldosterone system perspective in patients infected with COVID-19: contextualizing findings from the dapagliflozin in respiratory failure in patients with COVID-19 study
Moustafa, Diala Alhaj; Imran, Zainab; Ismail, Roua; Rayan, Menatallah; Gadeau, Alain Pierre; Eldassouki, Hussein; Abdulrahman, Nabeel; Mraiche, Fatima... more authors ... less authors ( Springer , 2022 , Article Review)Numerous studies demonstrate parallels between CVD, type 2 diabetes mellitus (T2DM) and COVID-19 pathology, which accentuate pre-existing complications in patients infected with COVID-19 and potentially exacerbate the infection ... -
Na+/H+ exchanger isoform 1 induced osteopontin expression in cardiomyocytes involves NFAT3/Gata4
Mlih, Mohamed; Abdulrahman, Nabeel; Gadeau, Alain-Pierre; Mohamed, Iman A.; Jaballah, Maiy; Mraiche, Fatima... more authors ... less authors ( Springer-Verlag , 2015 , Article)Osteopontin (OPN), a multifunctional glycophosphoprotein, has been reported to contribute to the development and progression of cardiac remodeling and hypertrophy. Cardiac-specific OPN knockout mice were protected against ... -
Na+/H+ exchanger isoform 1-induced osteopontin expression facilitates cardiomyocyte hypertrophy
Mohamed, Iman A.; Gadeau, Alain-Pierre; Fliegel, Larry; Lopaschuk, Gary; Mlih, Mohamed; Abdulrahman, Nabeel; Fillmore, Natasha; Mraiche, Fatima... more authors ... less authors ( Public Library of Science , 2015 , Article)Enhanced expression and activity of the Na+/H+ exchanger isoform 1 (NHE1) has been implicated in cardiomyocyte hypertrophy in various experimental models. The upregulation of NHE1 was correlated with an increase in osteopontin ...