Browsing by Author "Crovella, Sergio"
Now showing items 41-60 of 71
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Microalgae potential to protect from heavy metals-induced carcinogenicity
Hadjira, Hamai-Amara; Abou-Saleh, Haissam; A. Al-Ghouti, Mohammad; Crovella, Sergio; Saadaoui, Imen; Soubra, Lama... more authors ... less authors ( Elsevier , 2024 , Article)Toxic elements are present naturally in the environment; however, during the last century, their level has been continuously rising in the air, water, and soil due to anthropogenic activities, including urban runoff, ... -
The mitochondrial-related effect of the 905 nm photobiomodulation therapy on 50B11 sensory neurons
Zupin, Luisa; Crovella, Sergio; Milena, Cadenaro; Barbi, Egidio; Celsi, Fulvio ( Wiley , 2023 , Article)Photobiomodulation therapy (PBMT) is known as a complementary tool to alleviate pain sensation in patients, nevertheless, there is still a gap of knowledge on its mechanism of action, thus limiting its clinical employment. ... -
Molecular analysis of inflammatory diseases.
Almughrbi, Aya Hamad; Crovella, Sergio ( Wiley , 2022 , Article Review)If we try to describe the search for molecular actors involved in inflammatory diseases, the picture best representing this task is a mission to unexplored worlds. However, researchers nowadays have powerful tools to support ... -
Molecular detection of SARS-CoV-2 from indoor air samples in environmental monitoring needs adequate temporal coverage and infectivity assessment
Pierluigi, Barbieri; Zupin, Luisa; Licen, Sabina; Torboli, Valentina; Semeraro, Sabrina; Cozzutto, Sergio; Palmisani, Jolanda; Di Gilio, Alessia; de Gennaro, Gianluigi; Fontana, Francesco; Omiciuolo, Cinzia; Pallavicini, Alberto; Ruscio, Maurizio; Crovella, Sergio... more authors ... less authors ( Elsevier , 2021 , Article)The relevance of airborne exposure to SARS-CoV-2 in indoor environments is a matter of research and debate, with special importance for healthcare low-risk settings. Experimental approaches to the bioaerosol sampling are ... -
Multiomics integration in skin diseases with alterations in notch signaling pathway: PlatOMICs phase 1 deployment
Brandão, Lucas André Cavalcanti; Tricarico, Paola Maura; Gratton, Rossella; Agrelli, Almerinda; Zupin, Luisa; Abou-Saleh, Haissam; Moura, Ronald; Crovella, Sergio... more authors ... less authors ( MDPI , 2021 , Article Review)The high volume of information produced in the age of omics was and still is an important step to understanding several pathological processes, providing the enlightenment of complex molecular networks and the identification ... -
MYD88, IRAK3 and Rheumatoid Arthritis pathogenesis: Analysis of differential gene expression in CD14 + monocytes and the inflammatory cytokine levels.
Gomes da Silva, Isaura Isabelle Fonseca; Barbosa, Alexandre Domingues; Souto, Fabricio Oliveira; Maia, Maria de Mascena Diniz; Crovella, Sergio; Souza, Paulo Roberto Eleuterio de; Sandrin-Garcia, Paula... more authors ... less authors ( Elsevier , 2021 , Article)Rheumatoid arthritis (RA) is a well-known chronic inflammatory disorder. Two molecular players act in the inflammation balance of the disease: MyD88 (Myeloid differentiation primary response 88) is related to TLR (Toll-like ... -
Nanomedicine as a Potential Tool against Monkeypox.
Mohamed, Nura Adam; Zupin, Luisa; Mazi, Sarah Ismail; Al-Khatib, Hebah A; Crovella, Sergio ( MDPI , 2023 , Article Review)Human monkeypox is a rare viral zoonosis that was first identified in 1970; since then, this infectious disease has been marked as endemic in central and western Africa. The disease has always been considered rare and ... -
Neck circumference predicts mortality in hospitalized COVID-19 patients
Di Bella, Stefano; Zerbato, Verena; Sanson, Gianfranco; Roman-Pognuz, Erik; De Cristofaro, Paolo; Palermo, Andrea; Valentini, Michael; Gobbo, Ylenia; Jaracz, Anna Wladyslawa; Hrzica, Elizabeta Bozic; Bresani-Salvi, Cristiane Campello; Galindo, Alexandre Bezerra; Crovella, Sergio; Luzzati, Roberto... more authors ... less authors ( MDPI , 2021 , Article)We aimed to determine whether neck circumference predicts mortality among hospitalized COVID-19 patients with respiratory failure. We performed a prospective multicenter (Italy and Brasil) study carried out from March to ... -
Optimization of Anti-SARS-CoV-2 Treatments Based on Curcumin, Used Alone or Employed as a Photosensitizer.
Zupin, Luisa; Fontana, Francesco; Clemente, Libera; Borelli, Violetta; Ricci, Giuseppe; Ruscio, Maurizio; Crovella, Sergio... more authors ... less authors ( MDPI , 2022 , Article)Curcumin, the bioactive compound of the spice , has already been reported as a potential COVID-19 adjuvant treatment due to its immunomodulatory and anti-inflammatory properties. In this study, SARS-CoV-2 was challenged ... -
An overview of Zika virus genotypes and their infectivity
Bernardo-Menezes, Lucas Coêlho; Agrelli, Almerinda; de Oliveira, Ana Sofia Lima Estevão; de Moura, Ronald Rodrigues; Crovella, Sergio; Brandão, Lucas André Cavalcanti... more authors ... less authors ( Sociedade Brasileira de Medicina Tropical , 2022 , Article Review)Zika virus (ZIKV) is an enveloped, single-stranded RNA arbovirus belonging to the genus Flavivirus. It was first isolated from a sentinel monkey in Uganda in 1947. More recently, ZIKV has undergone rapid geographic expansion ... -
Paraviral cutaneous manifestations associated to SARS-CoV-2 Omicron variant
Zupin, Luisa; Moltrasio, Chiara; Tricarico, Paola Maura; Del Vecchio, Cecilia; Fontana, Francesco; Marzano, Angelo Valerio; Crovella, Sergio... more authors ... less authors ( Taylor and Francis Group , 2022 , Article)Background: The spreading of the SARS-CoV-2 Omicron variant is probably due to its increased transmissibility and ability to escape from neutralising antibodies. Cutaneous manifestations have been reported after infection ... -
Persistent viral infectivity after 27 days from COVID-19 symptoms onset
Zupin, Luisa; Fontana, Francesco; Clemente, Libera; Boschian-Bailo, Pierino; Ruscio, Maurizio; Crovella, Sergio... more authors ... less authors ( BMJ Publishing Group , 2021 , Article)The persistence of SARS-CoV- 2 in pharyngeal swabs belonging to patients affected by COVID-19 is not a rare occurrence. Indeed, the viral load determined through real-time reverse-transcriptase PCR (rRT-PCR) test peaks at ... -
Plant Antimicrobial Peptides as Potential Tool for Topic Treatment of Hidradenitis Suppurativa
Santos-Silva, Carlos André dos; Tricarico, Paola Maura; Vilela, Lívia Maria Batista; Roldan-Filho, Ricardo Salas; Amador, Vinícius Costa; d’Adamo, Adamo Pio; Rêgo, Mireli de Santana; Benko-Iseppon, Ana Maria; Crovella, Sergio... more authors ... less authors ( Frontiers Media , 2021 , Article)Among chronic skin autoinflammatory diseases, Hidradenitis Suppurativa (HS) stands out for its chronicity, highly variable condition, and profound impact on the patients’ quality of life. HS is characterized by suppurative ... -
Pleiotropic role of notch signaling in human skin diseases
Gratton, Rossella; Tricarico, Paola Maura; Moltrasio, Chiara; de Oliveira, Ana Sofia Lima Estevão; Brandão, Lucas; Marzano, Angelo Valerio; Zupin, Luisa; Crovella, Sergio... more authors ... less authors ( MDPI , 2020 , Article Review)Notch signaling orchestrates the regulation of cell proliferation, differentiation, migration and apoptosis of epidermal cells by strictly interacting with other cellular pathways. Any disruption of Notch signaling, either ... -
Proteomic study identifies glycolytic and inflammation pathways involved in recurrent otitis media
Ura, Blendi; Celsi, Fulvio; Zupin, Luisa; Arrigoni, Giorgio; Battisti, Ilaria; Gaita, Bartolomea; Grasso, Domenico Leonardo; Orzan, Eva; Sagredini, Raffaella; Barbi, Egidio; Crovella, Sergio... more authors ... less authors ( MDPI , 2020 , Article)Recurrent acute otitis media (RAOM) in children is clinically defined as the occurrence of at least three episodes of acute otitis media over a course of 6 months. A further common pathological condition of interest in the ... -
A rare loss-of-function genetic mutation suggest a role of dermcidin deficiency in hidradenitis suppurativa pathogenesis
Tricarico, Paola Maura; Gratton, Rossella; Santos-Silva, Carlos André dos; Moura, Ronald Rodrigues de; Ura, Blendi; Sommella, Eduardo; Campiglia, Pietro; Del Vecchio, Cecilia; Moltrasio, Chiara; Berti, Irene; D’Adamo, Adamo Pio; Elsherbini, Ahmed M.A.; Staudenmaier, Lena; Chersi, Karin; Boniotto, Michele; Krismer, Bernhard; Schittek, Birgit; Crovella, Sergio... more authors ... less authors ( Frontiers Media , 2022 , Article)Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with a multifactorial aetiology that involves a strict interplay between genetic factors, immune dysregulation and lifestyle. Familial forms represent ... -
Recent Developments in Nanomaterials-Based Drug Delivery and Upgrading Treatment of Cardiovascular Diseases
Mohamed, Nura A.; Marei, Isra; Crovella, Sergio; Abou-Saleh, Haissam ( MDPI , 2022 , Article)Cardiovascular diseases (CVDs) are the leading causes of morbidity and mortality worldwide. However, despite the recent developments in the management of CVDs, the early and long outcomes vary considerably in patients, ... -
SARS-CoV-2 does not replicate in HaCaT spontaneously immortalized human keratinocytes: implications for the pathogenesis of COVID-19-associated skin manifestations
Zupin, Luisa; Moltrasio, Chiara; Genovese, Giovanni; Milani, Margherita; Fontana, Francesco; Ruscio, Maurizio; Valerio Marzano, Angelo; Crovella, Sergio... more authors ... less authors ( John Libbey Eurotext , 2022 , Article)Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-related cutaneous manifestations have been reported [1], however, the direct or indirect role of SARS-CoV-2 infection in their pathophysiology is still debated ... -
SARS-CoV-2 modulates virus receptor expression in placenta and can induce trophoblast fusion, inflammation and endothelial permeability
Agostinis, Chiara; Toffoli, Miriam; Spazzapan, Mariagiulia; Balduit, Andrea; Zito, Gabriella; Mangogna, Alessandro; Zupin, Luisa; Salviato, Tiziana; Maiocchi, Serena; Romano, Federico; Crovella, Sergio; Fontana, Francesco; Braga, Luca; Confalonieri, Marco; Ricci, Giuseppe; Kishore, Uday; Bulla, Roberta... more authors ... less authors ( Frontiers Media , 2022 , Article)SARS-CoV-2 is a devastating virus that induces a range of immunopathological mechanisms including cytokine storm, apoptosis, inflammation and complement and coagulation pathway hyperactivation. However, how the infection ... -
SARS-CoV-2 RNA Recovery from Air Sampled on Quartz Fiber Filters: A Matter of Sample Preservation?
Licen, Sabina; Zupin, Luisa; Martello, Lorenzo; Torboli, Valentina; Semeraro, Sabrina; Gardossi, Anna Lilian; Greco, Enrico; Fontana, Francesco; Crovella, Sergio; Ruscio, Maurizio; Palmisani, Jolanda; Di Gilio, Alessia; Piscitelli, Prisco; Pallavicini, Alberto; Barbieri, Pierluigi... more authors ... less authors ( MDPI , 2022 , Report)The airborne route of transmission of SARS-CoV-2 was confirmed by the World Health Organization in April 2021. There is an urge to establish standardized protocols for assessing the concentration of SARS-CoV-2 RNA in air ...