تصفح حسب المؤلف "Issa, Khodr"
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Cadmium induces migration of colon cancer cells: Roles of reactive oxygen species, p38 and cyclooxygenase-2
Naji, Sara; Issa, Khodr; Eid, Assaad; Iratni, Rabah; Eid, Ali H. ( Cell Physiol Biochem Press GmbH & Co KG , 2019 , Article)Background/Aims: Cadmium (Cd) is a heavy metal contaminant whose toxicity is associated with colorectal cancer (CRC). However, the underlying molecular mechanisms of Cd-induced CRC malignancy remain obscure. Methods: A ... -
Estrogen increases expression of vascular alpha 2C adrenoceptor through the cAMP/Epac/JNK/AP-1 pathway and potentiates cold-induced vasoconstriction
Fardoun, Manal M.; Issa, Khodr; Maaliki, Dina; Nasser, Suzanne A.; Baydoun, Elias; Eid, Ali H.... more authors ... less authors ( Elsevier , 2020 , Article)Cutaneous cold-induced vasoconstriction is a normal physiological reaction mediated by alpha 2C-adrenergic receptors (α2C-ARs) expressed in vascular smooth muscle cells (VSMCs). When this reaction is exaggerated, Raynaud's ... -
Marjoram Relaxes Rat Thoracic Aorta Via a PI3-K/eNOS/cGMP Pathway.
Badran, Adnan; Baydoun, Elias; Samaha, Ali; Pintus, Gianfranco; Mesmar, Joelle; Iratni, Rabah; Issa, Khodr; Eid, Ali H... more authors ... less authors ( MDPI , 2019 , Article)Despite pharmacotherapeutic advances, cardiovascular disease (CVD) remains the primary cause of global mortality. Alternative approaches, such as herbal medicine, continue to be sought to reduce this burden. is recognized ... -
MicroRNAs as Potential Pharmaco-targets in Ischemia-Reperfusion Injury Compounded by Diabetes.
Dehaini, Hassan; Awada, Hussein; El-Yazbi, Ahmed; Zouein, Fouad A; Issa, Khodr; Eid, Assaad A; Ibrahim, Maryam; Badran, Adnan; Baydoun, Elias; Pintus, Gianfranco; Eid, Ali H... more authors ... less authors ( MDPI , 2019 , Article)Ischemia-Reperfusion (I/R) injury is the tissue damage that results from re-oxygenation of ischemic tissues. There are many players that contribute to I/R injury. One of these factors is the family of microRNAs (miRNAs), ... -
SARS-CoV-2 infection triggers more potent antibody-dependent cellular cytotoxicity (ADCC) responses than mRNA-, vector-, and inactivated virus-based COVID-19 vaccines
Zedan, Hadeel T.; Smatti, Maria K.; Al-Sadeq, Duaa W.; Al Khatib, Hebah A.; Nicolai, Eleonora; Pieri, Massimo; Bernardini, Sergio; Hssain, Ali Ait; Taleb, Sara; Qotba, Hamda; Issa, Khodr; Abu Raddad, Laith J.; Althani, Asmaa A.; Nasrallah, Gheyath K.; Yassine, Hadi M.... more authors ... less authors ( Wiley , 2024 , Article)Neutralizing antibodies (NAbs) are elicited after infection and vaccination and have been well studied. However, their antibody-dependent cellular cytotoxicity (ADCC) functionality is still poorly characterized. Here, we ... -
The role of α2-adrenergic receptors in hypertensive preeclampsia: A hypothesis
Maaliki, Dina; Issa, Khodr; Al Shehabi, Tuqa; El-Yazbi, Ahmed; Eid, Ali H. ( Wiley Blackwell , 2019 , Article Review)Preeclampsia, a major disorder of human pregnancy, manifests as persistent hypertension and proteinuria presenting after 20 weeks of pregnancy. Multiple systemic symptoms might be associated with preeclampsia including ... -
The therapeutic effects of adipose-derived mesenchymal stem cells on obesity and its associated diseases in diet-induced obese mice
jaber, Hala; Issa, Khodr; Eid, Ali; Saleh, Fatima A. ( Nature Research , 2021 , Article)Obesity is a global public health concern associated with increased risk of several comorbidities. Due to the limited effectiveness of current therapies, new treatment strategies are needed. Our aim was to examine the ... -
Ziziphus nummularia Inhibits Inflammation-Induced Atherogenic Phenotype of Human Aortic Smooth Muscle Cells
Fardoun, Manal; Al-Shehabi, Tuqa; El-Yazbi, Ahmed; Issa, Khodr; Zouein, Fouad; Maaliki, Dina; Iratni, Rabah; Eid, Ali H.... more authors ... less authors ( Hindawi Limited , 2017 , Article)Cardiovascular disease (CVD) continues to be the leading cause of death worldwide. Atherosclerosis is a CVD characterized by plaque formation resulting from inflammation-induced insults to endothelial cells, monocytes, and ...