Browsing by Author "Sorio, Claudio"
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Description of PTPRG genetic variants identified in a cohort of Chronic Myeloid Leukemia patients and their ability to influence response to Tyrosine kinase Inhibitors
Mohamed A., Ismail; Nasrallah, Gheyath K.; Monne, Maria; AlSayab, Ali; Yassin, Mohamed A.; Varadharaj, Govindarajulu; Younes, Salma; Sorio, Claudio; Cook, Richard; Modjtahedi, Helmout; Al-Dewik, Nader I.... more authors ... less authors ( Elsevier , 2022 , Article)Tyrosine kinase inhibitors (TKIs) have remarkably transformed Ph+ chronic myeloid leukemia (CML) management; however, TKI resistance remains a major clinical challenge. Mutations in BCR-ABL1 are well studied but fail to ... -
Management of chronic myeloid leukaemia: current treatment options, challenges, and future strategies.
Younes, Salma; Ismail, Mohamed A; Al-Jurf, Rana; Ziyada, Ayah; Nasrallah, Gheyath K; Abdulrouf, Palli Valapila; Nagy, Mohamed; Zayed, Hatem; Farrell, Thomas; Sorio, Claudio; Morsi, Hisham; Qoronfleh, M Walid; Al-Dewik, Nader I... more authors ... less authors ( taylor and francis online , 2023 , Article)Small molecule therapy is a critical component of targeted anticancer treatment, with tyrosine kinase inhibitors (TKIs) being the first compounds to treat the clonal Chronic Myelogenous Leukaemia (CML) translocation t ...