Browsing by Author "Kheraldine, Hadeel"
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Dasatinib and PD-L1 inhibitors provoke toxicity and inhibit angiogenesis in the embryo
Maha, Al-Asmakh; Bawadi, Hiba; Hamdan, Munia; Gupta, Ishita; Kheraldine, Hadeel; Jabeen, Ayesha; Rizeq, Balsam; Al Moustafa, Ala-Eddin... more authors ... less authors ( Elsevier , 2021 , Article)Dasatinib is a targeted cancer therapy, while programmed death ligand 1 (PD-L1) inhibitors are a form of immune checkpoint therapy used to treat various types of cancers. Several studies showed the potential efficacy of ... -
Effects of neratinib on angiogenesis and the early stage of the embryo using chicken embryo as a model.
Kheraldine, Hadeel; Hassan, Arij Fouzat; Alhussein, Hashim; Al-Thawadi, Hamda; Vranic, Semir; Al Moustafa, Ala-Eddin... more authors ... less authors ( the Association of Basic Medical Sciences , 2023 , Article)Angiogenesis is the process of forming new blood capillaries from pre-existing vessels. Even though it is essential during normal development, it plays a major role in cancer progression. Neratinib is a pan-human epidermal ... -
The Impact of Pamam Dendrimers on Her2-Positive Breast Cancer and the Early Stages of Embryogenesis
Kheraldine, Hadeel (2020 , Master Thesis)Poly (amidoamine) (PAMAM) dendrimers are widely used in drug delivery systems and gene transfection as drug carriers. They also exert several biological effects including modulating gene expression and interfering with ... -
Mesoporous silica coated carbon nanofibers reduce embryotoxicity via ERK and JNK pathways
Abdo, Ghada G.; Gupta, Ishita; Kheraldine, Hadeel; Rizeq, Balsam; Zagho, Moustafa M.; Khalil, Ashraf; Elzatahry, Ahmed; Al Moustafa, Ala-Eddin... more authors ... less authors ( Elsevier Ltd , 2021 , Article)Carbon nanofibers (CNFs) have been implicated in biomedical applications, yet, they are still considered as a potential hazard. Conversely, mesoporous silica is a biocompatible compound that has been used in various ... -
Metformin and HER2-positive breast cancer: Mechanisms and therapeutic implications
Bashraheel, Sara S.; Kheraldine, Hadeel; Khalaf, Sarah; Moustafa, Ala Eddin Al ( Elsevier , 2023 , Article)Due to the strong association between diabetes and cancer incidents, several anti-diabetic drugs, including metformin, have been examined for their anticancer activity. Metformin is a biguanide antihyperglycemic agent used ... -
Quantification of the growth suppression of HER2+ breast cancer colonies under the effect of trastuzumab and PD-1/PD-L1 inhibitor.
Padmanabhan, Regina; Kheraldine, Hadeel; Gupta, Ishita; Meskin, Nader; Hamad, Anas; Vranic, Semir; Al Moustafa, Ala-Eddin... more authors ... less authors ( Frontiers Media , 2022 , Article)Immune checkpoint blockade (ICB)-based therapy is revolutionizing cancer treatment by fostering successful immune surveillance and effector cell responses against various types of cancers. However, patients with HER2+ ... -
Significant Toxic Effect of Carbon Nanofibers at the Early Stage of Embryogenesis
Abdo, Ghada G.; Kheraldine, Hadeel; Gupta, Ishita; Rizeq, Balsam; Elzatahry, Ahmed; Al Moustafa, Ala-Eddin; Khalil, Ashraf... more authors ... less authors ( NLM (Medline) , 2020 , Article)Implementation of carbon nanofibers (CNFs) in biomedical applications have successful outcomes, however, they are still considered as a potential hazard. We herein used avian embryos at 3 days and its chorioallantoic ... -
Targeting HER2-positive breast cancer cells by a combination of dasatinib and BMS-202: Insight into the molecular pathways.
Kheraldine, Hadeel; Gupta, Ishita; Cyprian, Farhan Sachal; Vranic, Semir; Al-Farsi, Halema F; Merhi, Maysaloun; Dermime, Said; Al Moustafa, Ala-Eddin... more authors ... less authors ( Springer Nature , 2024 , Article)Recent investigations have reported the benefits of using a tyrosine kinase inhibitor, dasatinib (DA), as well as programmed death-ligand 1 (PD-L1) inhibitors in the management of several solid tumors, including breast ...