تصفح حسب المؤلف "Bedhiafi, Takwa"
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Curcumin and Derivatives in Nanoformulations with Therapeutic Potential on Colorectal Cancer
Idoudi, Sourour; Bedhiafi, Takwa; Hijji, Yousef Mohammad; Billa, Nashiru ( Springer Science and Business Media Deutschland GmbH , 2022 , Article)There is growing concern in the rise of colorectal cancer (CRC) cases globally, and with this rise is the presentation of drug resistance. Like other cancers, current treatment options are either invasive or manifest severe ... -
Nano-vitamin C: A promising candidate for therapeutic applications
Bedhiafi, Takwa; Idoudi, Sourour; Fernandes, Queenie; Al-Zaidan, Lobna; Uddin, Shahab; Dermime, Said; Billa, Nashiru; Merhi, Maysaloun... more authors ... less authors ( Elsevier , 2023 , Article Review)Vitamin C is an important nutrient implicated in different physiological functions in humans. Despite its important biological functions, therapeutic applications of vitamin C are rare and its use is further impacted by ... -
A novel approach of encapsulating curcumin and succinylated derivative in mannosylated-chitosan nanoparticles
Idoudi, Sourour; Hijji, Yousef; Bedhiafi, Takwa; Korashy, Hesham M.; Uddin, Shahab; Merhi, Maysaloun; Dermime, Said; Billa, Nashiru... more authors ... less authors ( Elsevier , 2022 , Article)Curcumin (CUR) manifests anti-colon cancer activity but suffers from low solubility, bioavailability, and instability, rendering it not as effective as its chemotherapeutic cousins. Here, we conjugate CUR to succinic ... -
Role of HMGB1 and its associated signaling pathways in human malignancies
Sourour, Idoudi; Bedhiafi, Takwa; Pedersen, Shona; Elahtem, Mohamed; Alremawi, Izzaldin; Akhtar, Sabah; Dermime, Said; Merhi, Maysaloun; Uddin, Shahab... more authors ... less authors ( Elsevier , 2023 , Article)The High-Mobility Group Box-1 (HMGB1), a non-histone chromatin-associated protein, plays a crucial role in cancer growth and response to therapy as it retains a pivotal role in promoting both cell death and survival. HMGB1 ... -
Shrinking the battlefield in cancer therapy: Nanotechnology against cancer stem cells
Queenie, Fernandes; Therachiyil, Lubna; Khan, Abdul Q.; Bedhiafi, Takwa; Korashy, Hesham M; Bhat, Ajaz A.; Uddin, Shahab... more authors ... less authors ( Elsevier , 2023 , Article)Cancer remains one of the leading causes of mortality worldwide, presenting a significant healthcare challenge owing to the limited efficacy of current treatments. The application of nanotechnology in cancer treatment ... -
Studies on anti-colon cancer potential of nanoformulations of curcumin and succinylated curcumin in mannosylated chitosan
Sourour, Idoudi; Bedhiafi, Takwa; Sahir, Fairooz; Hijji, Yousef; Uddin, Shahab; Merhi, Maysaloun; Dermime, Said; Billa, Nashiru... more authors ... less authors ( Elsevier , 2023 , Article)Colon cancer (CRC) is the second leading cause of death and the third most diagnosed cancer worldwide. Although curcumin (CUR) has demonstrated a potent anticancer activity, it is characterized by its poor solubility, low ...