تصفح حسب المؤلف "Kumar, D. Thirumal"
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Bioinformatics classification of mutations in patients with Mucopolysaccharidosis IIIA
Tanwar, Himani; Kumar, D Thirumal; Doss, C George Priya; Zayed, Hatem ( Springer US , 2019 , Article)Mucopolysaccharidosis (MPS) IIIA, also known as Sanfilippo syndrome type A, is a severe, progressive disease that affects the central nervous system (CNS). MPS IIIA is inherited in an autosomal recessive manner and is ... -
Genotype-phenotype correlation in patients with isovaleric acidaemia: comparative structural modelling and computational analysis of novel variants.
Zaki, Osama K; Priya Doss C, George; Ali, Salsabil A; Murad, Ghadeer G; Elashi, Shaima A; Ebnou, Maryam S A; Kumar D, Thirumal; Khalifa, Ola; Gamal, Radwa; El Abd, Heba S A; Nasr, Bilal N; Zayed, Hatem... more authors ... less authors ( Oxford University Press (OUP) , 2017 , Article)Isovaleric acidaemia (IVA) is an autosomal recessive inborn error of leucine metabolism. It is caused by a deficiency in the mitochondrial isovaleryl-CoA dehydrogenase (IVD) enzyme. In this study, we investigated eight ... -
Integrative Bioinformatics Approaches to Map Potential Novel Genes and Pathways Involved in Ovarian Cancer.
Kumar, S Udhaya; Kumar, D Thirumal; R, Siva; Doss, C George Priya; Zayed, Hatem ( Frontiers Media , 2019 , Article)Ovarian cancer (OC) is the seventh most commonly detected cancer among women. This study aimed to map the hub and core genes and potential pathways that might be involved in the molecular pathogenesis of OC. In the present ... -
Molecular dynamics, residue network analysis, and cross-correlation matrix to characterize the deleterious missense mutations in GALE causing galactosemia III.
Kumar, S Udhaya; Sankar, Srivarshini; Kumar, D Thirumal; Younes, Salma; Younes, Nadin; Siva, R; Doss, C George Priya; Zayed, Hatem... more authors ... less authors ( Springer , 2021 , Article)Epimerase-deficiency galactosemia (EDG) is caused by mutations in the UDP-galactose 4'-epimerase enzyme, encoded by gene GALE. Catalyzing the last reaction in the Leloir pathway, UDP-galactose-4-epimerase catalyzes the ... -
A review of novel coronavirus disease (COVID-19): based on genomic structure, phylogeny, current shreds of evidence, candidate vaccines, and drug repurposing
Kumar, S. Udhaya; Priya, N. Madhana; Nithya, S. R.; Kannan, Priyanka; Jain, Nikita; Kumar, D. Thirumal; Magesh, R.; Younes, Salma; Zayed, Hatem; Doss, C. George Priya... more authors ... less authors ( Springer Verlag , 2021 , Article Review)Coronavirus disease (COVID-19) pandemic is instigated by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As of March 13, 2021, more than 118.9 million cases were infected with COVID-19 worldwide. SARS-CoV-2 ... -
Structure-Based Virtual Screening to Identify Novel Potential Compound as an Alternative to Remdesivir to Overcome the RdRp Protein Mutations in SARS-CoV-2.
Kumar D, Thirumal; Shaikh, Nishaat; Kumar S, Udhaya; Doss C, George Priya; Zayed, Hatem ( Frontiers Media , 2021 , Article)The number of confirmed COVID-19 cases is rapidly increasing with no direct treatment for the disease. Few repurposed drugs, such as Remdesivir, Chloroquine, Hydroxychloroquine, Lopinavir, and Ritonavir, are being tested ...