Browsing by Author "Suleman, Muhammad"

Now showing items 1-19 of 19

    • Abrogation of ORF8-IRF3 binding interface with Carbon nanotube derivatives to rescue the host immune system against SARS-CoV-2 by using molecular screening and simulation approaches. 

      Suleman, Muhammad; Murshed, Abduh; Imran, Kashif; Khan, Abbas; Ali, Zafar; ... more authors ( BMC , 2024 , Article)
      The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to over six million deaths worldwide. In human immune system, the type 1 interferon (IFN) pathway plays a crucial role in fighting viral infections. However, ...

    • Complement C5a and Clinical Markers as Predictors of COVID-19 Disease Severity and Mortality in a Multi-Ethnic Population 

      Cyprian, Farhan S.; Suleman, Muhammad; Abdelhafez, Ibrahim; Doudin, Asmma; Masud Danjuma, Ibn Mohammed; ... more authors ( Frontiers Media S.A. , 2021 , Article)
      Coronavirus disease-2019 (COVID-19) was declared as a pandemic by WHO in March 2020. SARS-CoV-2 causes a wide range of illness from asymptomatic to life-threatening. There is an essential need to identify biomarkers to ...

    • Curcumin induces apoptosis via downregulation of SKP2 and induction of GADD45A/CDKN1A expression through generation of ROS in cutaneous T-cell lymphoma cells 

      Suleman, Muhammad; Ahmad, Fareed; Mariyam, Zahwa; Habeeba, Ummu; Prabhu, Kirti S.; ... more authors ( Elsevier , 2025 , Article)
      Curcumin, a plant derived natural product isolated from Curcuma longa. The aim of this study is to investigate the anti-proliferative effects and the underlying mechanisms of curcumin in Cutaneous T cell lymphoma (CTCL), ...

    • Engineered Anti-Microbial Peptides Inhibit Cell Viability, Promote Apoptosis, and Induce Cell Cycle Arrest in SW620 Human Colon Adenocarcinoma Cells. 

      Hashem, Sheema; Bhat, Ajaz A; Nisar, Sabah; Uddin, Shahab; Merhi, Maysaloun; ... more authors ( Elsevier , 2025 , Article)
      Colorectal cancer (CRC) is one of the most common malignancies worldwide, and despite advances in treatment, there remains a critical need for novel therapeutic approaches. Recently, anti-microbial peptides (AMPs) have ...

    • Forecasting the effects of smoking prevalence scenarios on years of life lost and life expectancy from 2022 to 2050: a systematic analysis for the Global Burden of Disease Study 2021 

      Dana, Bryazka; Reitsma, Marissa B; Abate, Yohannes Habtegiorgis; Abd Al Magied, Abdallah H A; Abdelkader, Atef; ... more authors ( Elsevier , 2024 , Article)
      BackgroundSmoking is the leading behavioural risk factor for mortality globally, accounting for more than 175 million deaths and nearly 4·30 billion years of life lost (YLLs) from 1990 to 2021. The pace of decline in smoking ...

    • Global age-sex-specific all-cause mortality and life expectancy estimates for 204 countries and territories and 660 subnational locations, 1950–2023: a demographic analysis for the Global Burden of Disease Study 2023 

      Austin E, Schumacher; Zheng, Peng; Barber, Ryan M; A, Bhoomadevi; Aalipour, Mohammad Amin; ... more authors ( Elsevier , 2025 , fla  &   Article)
      BackgroundComprehensive, comparable, and timely estimates of demographic metrics—including life expectancy and age-specific mortality—are essential for evaluating, understanding, and addressing trends in population health. ...

    • Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 

      Michael, Brauer; Roth, Gregory A; Aravkin, Aleksandr Y; Zheng, Peng; Abate, Kalkidan Hassen; ... more authors ( Elsevier Ltd. , 2024 , Article)
      Background: Understanding the health consequences associated with exposure to risk factors is necessary to inform public health policy and practice. To systematically quantify the contributions of risk factor exposures to ...

    • Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023 

      Mohsen, Naghavi; Kyu, Hmwe Hmwe; A, Bhoomadevi; Aalipour, Mohammad Amin; Aalruz, Hasan; ... more authors ( Elsevier , 2025 , fla  &   Article)
      BackgroundTimely and comprehensive analyses of causes of death stratified by age, sex, and location are essential for shaping effective health policies aimed at reducing global mortality. The Global Burden of Diseases, ...

    • Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021 

      Natalia V, Bhattacharjee; Schumacher, Austin E; Aali, Amirali; Abate, Yohannes Habtegiorgis; Abbasgholizadeh, Rouzbeh; ... more authors ( Elsevier , 2024 , Article)
      Background Accurate assessments of current and future fertility—including overall trends and changing population age structures across countries and regions—are essential to help plan for the profound social, economic, ...

    • Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 

      Alize J, Ferrari; Santomauro, Damian Francesco; Aali, Amirali; Abate, Yohannes Habtegiorgis; Abbafati, Cristiana; ... more authors ( Elsevier , 2024 , Article)
      Background Detailed, comprehensive, and timely reporting on population health by underlying causes of disability and premature death is crucial to understanding and responding to complex patterns of disease and injury ...

    • Global, regional, and national age-sex-specific burden of diarrhoeal diseases, their risk factors, and aetiologies, 1990–2021, for 204 countries and territories: a systematic analysis for the Global Burden of Disease Study 2021 

      Hmwe Hmwe, Kyu; Vongpradith, Avina; Dominguez, Regina-Mae Villanueva; Ma, Jianing; Albertson, Samuel B; ... more authors ( Elsevier , 2024 , Article)
      BackgroundDiarrhoeal diseases claim more than 1 million lives annually and are a leading cause of death in children younger than 5 years. Comprehensive global estimates of the diarrhoeal disease burden for specific age ...

    • Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021 

      Kanyin Liane, Ong; Stafford, Lauryn K; McLaughlin, Susan A; Boyko, Edward J; Vollset, Stein Emil; ... more authors ( Elsevier , 2023 , Article)
      BackgroundDiabetes is one of the leading causes of death and disability worldwide, and affects people regardless of country, age group, or sex. Using the most recent evidentiary and analytical framework from the Global ...

    • Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 

      Jaimie D, Steinmetz; Seeher, Katrin Maria; Schiess, Nicoline; Nichols, Emma; Cao, Bochen; ... more authors ( Elsevier , 2024 , Article)
      Background Disorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous ...

    • Global, regional, and national burden of upper respiratory infections and otitis media, 1990–2021: a systematic analysis from the Global Burden of Disease Study 2021 

      Sirota, Sarah Brooke; Doxey, Matthew C; Dominguez, Regina-Mae Villanueva; Bender, Rose Grace; Vongpradith, Avina; ... more authors ( Elsevier Ltd. , 2024 , Article)
      Background: Upper respiratory infections (URIs) are the leading cause of acute disease incidence worldwide and contribute to a substantial health-care burden. Although acute otitis media is a common complication of URIs, ...

    • Global, regional, and national stillbirths at 20 weeks' gestation or longer in 204 countries and territories, 1990–2021: findings from the Global Burden of Disease Study 2021 

      Comfort, Haley; McHugh, Theresa A; Schumacher, Austin E; Harris, Ashley; May, Erin A; ... more authors ( Elsevier Ltd. , 2024 , Article)
      Background: Stillbirth is a devastating and often avoidable adverse pregnancy outcome. Monitoring stillbirth levels and trends—in a comprehensive manner that leaves no one uncounted—is imperative for continuing progress ...

    • In silico design of multi-epitope vaccines against the hantaviruses by integrated structural vaccinology and molecular modeling approaches 

      Ali, Liaqat; Rauf, Sobiah; Khan, Abbas; Rasool, Samreen; Raza, Rabail Zehra; ... more authors ( Public Library of Science , 2024 , Article)
      Hantaviruses are single-stranded RNA viruses belonging to the family Bunyaviridae that causes hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS) worldwide. Currently, there is no ...

    • Molecular Screening and Free Energy Calculations-Based Exploration of Medicinal Phytocompounds Chemical Space to Abrogate G9R-E4R Complex from Monkeypox: A Current Global Health Threat 

      Suleman, Muhammad; Ejaz, Hadiqa; Waheed, Yasir; Hussain, Zahid; Iqbal, Arshad; ... more authors ( Wiley-VCH , 2025 , Article)
      The current monkeypox virus outbreak is probably linked with the novel substitutions in the G9R protein of the replication complex. The G9R-E4R interface act as a potential druggable site for the inhibition of monkeypox ...

    • Repurposing Nirmatrelvir for Hepatocellular Carcinoma: Network Pharmacology and Molecular Dynamics Simulations Identify HDAC3 as a Key Molecular Target 

      Suleman, Muhammad; Arbab, Hira; Yassine, Hadi M.; Sayaf, Abrar Mohammad; Ilahi, Usama; ... more authors ( MDPI , 2025 , Article)
      Background: Hepatocellular carcinoma (HCC) is one of the most common and fatal malignancies worldwide, characterized by remarkable molecular heterogeneity and poor clinical outcomes. Despite advancements in diagnosis and ...

    • Temporal patterns of cancer burden in Asia, 1990–2019: a systematic examination for the Global Burden of Disease 2019 study 

      Rajesh, Sharma; Abbastabar, Hedayat; Abdulah, Deldar Morad; Abidi, Hassan; Abolhassani, Hassan; ... more authors ( Elsevier , 2024 , Article)
      BackgroundCancers represent a challenging public health threat in Asia. This study examines the temporal patterns of incidence, mortality, disability and risk factors of 29 cancers in Asia in the last three decades. ...