Browsing by Author "Uddin, Shahab"
Now showing items 1-20 of 104
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Analysis of signaling cascades from myeloma cells treated with pristimerin
( Elsevier , 2022 , Book chapter)Multiple myeloma (MM) is the 2nd most frequently diagnosed blood cancer after non-Hodgkin's lymphoma. The present study aimed to identify the differentially expressed genes (DEGs) between the control and pristimerin-treated ... -
Anti-hypertrophic effect of Na+/H+ exchanger-1 inhibition is mediated by reduced cathepsin B
( Elsevier , 2020 , Article)Previous studies have established the role of Na+/H+ exchanger isoform-1 (NHE1) and cathepsin B (Cat B) in the development of cardiomyocyte hypertrophy (CH). Both NHE1 and Cat B are activated under acidic conditions ... -
Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells
( Elsevier , 2022 , Article)Neosetophomone B (NSP–B), a meroterpenoid fungal secondary metabolite, was investigated for its anticancer potential in leukemic cell lines (K562 and U937). NSP-B treatment of leukemic cells suppressed cell viability by ... -
Anticancer activity of Neosetophomone B, A Fungal Secondary Metabolite, against Hematological Malignancies
( Qatar University Press , 2021 , Poster)Cancer is one of the most life threatening diseases, causing nearly 13% death in the worldwide. Leukemia, cancer of the hematopoetic cells is the main cause of cancer death in adults and children. Therapeutic agents used ... -
Anticancer Potential and Molecular Targets of Pristimerin in Human Malignancies
( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article Review)The growing global burden of malignant tumors with increasing incidence and mortality rates underscores the urgent need for more effective and less toxic therapeutic options. Herbal compounds are being increasingly studied ... -
Anticancer potential of sanguinarine for various human malignancies
( Future Medicine Ltd. , 2017 , Article Review)Sanguinarine (Sang) - a benzophenanthridine alkaloid extracted from Sanguinaria canadensis - exhibits antioxidant, anti-inflammatory, proapoptotic and growth inhibitory activities on tumor cells of various cancer types as ... -
Applications of polydopaminic nanomaterials in mucosal drug delivery
( Elsevier , 2023 , Article Review)Polydopamine (PDA) is a biopolymer with unique physicochemical properties, including free-radical scavenging, high photothermal conversion efficiency, biocompatibility, biodegradability, excellent fluorescent and theranostic ... -
Aryl Hydrocarbon Receptor Promotes Cell Growth, Stemness Like Characteristics, and Metastasis in Human Ovarian Cancer via Activation of PI3K/Akt, β-Catenin, and Epithelial to Mesenchymal Transition Pathways
( Multidisciplinary Digital Publishing Institute (MDPI) , 2022 , Article)Ovarian cancer (OC) ranks first in cancer-related deaths out of all female reproductive malignancies with high-pitched tumor relapse and chemoresistance. Several reports correlate cancer occurrences with exposure to ... -
Association between exposure to polycyclic aromatic hydrocarbons and reproductive health outcomes: a systematic review and meta-analysis
( Springer Nature , 2025 , Article)Background: Polycyclic aromatic hydrocarbons (PAHs) are widespread environmental pollutants with known harmful effects on human health. However, their specific impact on reproductive outcomes, both cancer-related and ... -
Association between maternal exposure to polycyclic aromatic hydrocarbons and birth anthropometric outcomes: A systematic review and meta-analysis
( Elsevier , 2024 , Article Review)BackgroundPrevious research has proposed that exposure to polycyclic aromatic hydrocarbons (PAHs) during pregnancy could potentially lead to a higher risk of adverse birth anthropometric outcomes. However, the current ... -
Association between metabolic risk, oxidative stress and psychological parameters amongst sample of nurses working in Doha, Qatar
( Elsevier , 2025 , Article)BackgroundShift workers are recognized to experience circadian rhythm disturbances, metabolic risks, and oxidative stress, increasing their susceptibility to numerous diseases. This study compared day and rotating shift ... -
Association of genes with phenotype in autism spectrum disorder.
( Impact Journals , 2019 , Article Review)Autism spectrum disorder (ASD) is a genetic heterogeneous neurodevelopmental disorder that is characterized by impairments in social interaction and speech development and is accompanied by stereotypical behaviors such as ... -
Beyond genetics: Exploring the role of epigenetic alterations in breast cancer
( Elsevier , 2024 , Article Review)Breast cancer remains a major global health challenge. Its rising incidence is attributed to factors such as delayed diagnosis, the complexity of its subtypes, and increasing drug resistance, all contributing to less-than-ideal ... -
Bioinformatics Analysis Reveals FOXM1/BUB1B Signaling Pathway as a Key Target of Neosetophomone B in Human Leukemic Cells: A Gene Network-Based Microarray Analysis
( Frontiers Media S.A. , 2022 , Article)Abnormal expression of Forkhead box protein M1 (FOXM1) and serine/threonine kinase Budding uninhibited by benzimidazoles 1 (BUB1B) contributes to the development and progression of several cancers, including chronic ... -
Bortezomib exerts its anti-cancer activity through the regulation of Skp2/p53 axis in non-melanoma skin cancer cells and C. elegans
( Springer Nature , 2024 , Article)Non-melanoma skin cancer (NMSC), encompassing basal and squamous cell carcinoma, is the most prevalent cancer in the United States. While surgical removal remains the conventional therapy with a 95% 5-year cure rate, there ... -
Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance
( Springer , 2024 , Article Review)Cancer is a complex disease displaying a variety of cell states and phenotypes. This diversity, known as cancer cell plasticity, confers cancer cells the ability to change in response to their environment, leading to ... -
Chronic inflammation and cancer; the two sides of a coin
( Elsevier , 2024 , Article Review)The correlation between chronic inflammation and cancer was initially identified in the 19th century. Biomolecules like interleukins, chemokines, tumor necrosis factors, growth factors, and adhesion molecules, which regulate ... -
Circulating exosomal immuno-oncological checkpoints and cytokines are potential biomarkers to monitor tumor response to anti-PD-1/PD-L1 therapy in non-small cell lung cancer patients
( Frontiers Media S.A. , 2023 , Article)Immune checkpoint inhibitors (ICIs) including anti-PD-1 and anti-PD-L1 antibodies, have significantly changed the treatment outcomes of NSCLC patients with better overall survival. However, 15-40% of the patients still ... -
Claudin-1, A Double-Edged Sword in Cancer.
( MDPI , 2020 , Article Review)Claudins, a group of membrane proteins involved in the formation of tight junctions, are mainly found in endothelial or epithelial cells. These proteins have attracted much attention in recent years and have been implicated ... -
Correction to: Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance (Molecular Cancer, (2020), 19, 1, (57), 10.1186/s12943-020-01175-9)
( BMC , 2020 , Article)Following the publication of the original article [1], authors have noticed that one of the authors, Syed Shadab Raza, was missing in the Authors’ Contributions section. Please see below updated section.
