Browsing by Author "Sif, Said"
Now showing items 1-6 of 6
-
Opposing calcium-dependent signalling pathways control skeletal muscle differentiation by regulating a chromatin remodelling enzyme
Nasipak, Brian T.; Padilla-Benavides, Teresita; Green, Karin M.; Leszyk, John D.; Mao, Wenjie; Konda, Silvana; Sif, Said; Shaffer, Scott A.; Ohkawa, Yasuyuki; Imbalzano, Anthony N.... more authors ... less authors ( Nature Publishing Group , 2015 , Article)Calcium signalling is important for differentiation-dependent gene expression, but is also involved in other cellular functions. Therefore, mechanisms must exist to distinguish calcium signalling relevant to differentiation. ... -
Protein arginine methyltransferase 5 (PRMT5) promotes survival of lymphoma cells via activation of WNT/B-catenin and AKT/GSK3B proliferative signaling
Chung, Jihyun; Karkhanis, Vrajesh; Baiocchi, Robert A.; Sif, Said ( American Society for Biochemistry and Molecular Biology Inc. , 2019 , Article)Epigenetic regulation by the type II protein arginine methyltransferase, PRMT5, plays an essential role in the control of cancer cell proliferation and tumorigenesis. In this report, we investigate the relationship between ... -
Role of Protein Arginine Methyltransferase 5 (PRMT5) in WNT/β--CATENIN proliferative signaling in breast cancer
Shailesh, Harshita (2020 , Dissertation)Protein arginine methyltransferase 5 (PRMT5) activity is dysregulated in many aggressive cancers and its enhanced levels are associated with increased tumor growth and survival. In this study, we show that PRMT5 is ... -
Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation
Alinari, Lapo; Mahasenan, Kiran V.; Yan, Fengting; Karkhanis, Vrajesh; Chung, Ji-Hyun; Smith, Emily M.; Quinion, Carl; Smith, Porsha L.; Kim, Lisa; Patton, John T.; Lapalombella, Rosa; Yu, Bo; Wu, Yun; Roy, Satavisha; De Leo, Alessandra; Pileri, Stefano; Agostinelli, Claudio; Ayers, Leona; Bradner, James E.; Chen-Kiang, Selina; Elemento, Olivier; Motiwala, Tasneem; Majumder, Sarmila; Byrd, John C.; Jacob, Samson; Sif, Said; Li, Chenglong; Baiocchi, Robert A.... more authors ... less authors ( American Society of Hematology , 2015 , Article)Epigenetic events that are essential drivers of lymphocyte transformation remain incompletely characterized. We used models of Epstein-Barr virus (EBV)–induced B-cell transformation to document the relevance of protein ... -
Towards understanding the genetics of Autism
Shailesh, Harshita; Gupta, Ishita; Sif, Said; Ouhtit, Allal ( Frontiers in Bioscience , 2016 , Article Review)Autism spectrum disorder (ASD) includes a group of neurodevelopmental disorders that affect communication skills, social interaction and intellectual ability. Despite evidence suggesting a strong genetic link with ASD, the ... -
Transcriptional and post-transcriptional control of adipocyte differentiation by Jumonji domain-containing protein 6
Hu, Yu-Jie; Belaghzal, Houda; Hsiao, Wen-Yu; Qi, Jun; Bradner, James E.; Guertin, David A.; Sif, Said; Imbalzano, Anthony N.... more authors ... less authors ( Oxford University Press , 2015 , Article)Jumonji domain-containing protein 6 (JMJD6) is a nuclear protein involved in histone modification, transcription and RNA processing. Although JMJD6 is crucial for tissue development, the link between its molecular functions ...