Browsing by Author "El-Kadi, Ayman O.S."
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5-, 12- and 15-Hydroxyeicosatetraenoic acids induce cellular hypertrophy in the human ventricular cardiomyocyte, RL-14 cell line, through MAPK- and NF-κB-dependent mechanism
Maayah, Zaid H.; El-Kadi, Ayman O.S. ( Springer Verlag , 2016 , Article)Recent studies have established the role of mid-chain hydroxyeicosatetraenoic acids (HETEs) in the development of cardiovascular disease. Mid-chain HETEs have been reported to have vasoconstrictive and pro-inflammatory ... -
Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms
Anwar-Mohamed, Anwar; Elshenawy, Osama H.; Soshilov, Anatoly A.; Denison, Michael S.; Le, X. Chris; Klotz, Lars-Oliver; El-Kadi, Ayman O.S.... more authors ... less authors ( Elsevier Inc. , 2014 , Article)Activation of the aryl hydrocarbon receptor (AhR) ultimately leads to the induction of the carcinogen-activating enzyme cytochrome P450 1A1 (CYP1A1), and activation of the nuclear factor-erythroid 2 p45-related factor 2 ... -
The role of mid-chain hydroxyeicosatetraenoic acids in the pathogenesis of hypertension and cardiac hypertrophy
Maayah, Zaid H.; El-Kadi, Ayman O.S. ( Springer Verlag , 2016 , Article Review)The incidence, prevalence, and hospitalization rates associated with cardiovascular diseases (CVDs) are projected to increase substantially in the world. Understanding of the biological and pathophysiological mechanisms ...