Browsing by Author "Burgon, Patrick G."

Now showing items 1-8 of 8

    • Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes (hiPSC-CMs) as a Platform for Modeling Arrhythmias 

      Lin, Lisa; Barszczewski, Tiffany; Burgon, Patrick G.; Tibbits, Glen F. ( Springer Nature , 2022 , Book chapter)
      Cardiac arrhythmias can arise due to a host of both genetic and acquired factors. Specifically, the genetic basis of arrhythmogenesis is not fully understood due to the lack of robust models that reliably recapitulate human ...

    • MicroRNA205: A Key Regulator of Cardiomyocyte Transition from Proliferative to Hypertrophic Growth in the Neonatal Heart 

      Weldrick, Jonathan J.; Yi, Rui; Megeney, Lynn A.; Burgon, Patrick G. ( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Article)
      The mammalian myocardium grows rapidly during early development due to cardiomyocyte proliferation, which later transitions to cell hypertrophy to sustain the heart’s postnatal growth. Although this cell transition in the ...

    • MLIP and Its Potential Influence on Key Oncogenic Pathways 

      Hamwi, Mahmoud N.; Elsayed, Engy; Dabash, Hanan; Abuawad, Amani; Aweer, Noor A.; ... more authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2024 , Other)
      Muscle-enriched A-type lamin-interacting protein (MLIP) is an emerging protein involved in cellular homeostasis and stress adaptation. Eukaryotic cells regulate various cellular processes, including metabolism, DNA repair, ...

    • MLIP causes recessive myopathy with rhabdomyolysis, myalgia and baseline elevated serum creatine kinase 

      Lopes Abath Neto, Osorio; Medne, Livija; Donkervoort, Sandra; Rodríguez-García, Maria Elena; Bolduc, Véronique; ... more authors ( Oxford University Press , 2021 , Article)
      Striated muscle needs to maintain cellular homeostasis in adaptation to increases in physiological and metabolic demands. Failure to do so can result in rhabdomyolysis. The identification of novel genetic conditions ...

    • Muscle enriched lamin interacting protein (Mlip) binds chromatin and is required for myoblast differentiation 

      Ahmady, Elmira; Blais, Alexandre; Burgon, Patrick G. ( MDPI , 2021 , Article)
      Muscle‐enriched A‐type lamin‐interacting protein (Mlip) is a recently discovered Amniota gene that encodes proteins of unknown biological function. Here we report Mlip’s direct interaction with chromatin, and it may function ...

    • Regulatory Mechanisms That Guide the Fetal to Postnatal Transition of Cardiomyocytes 

      Burgon, Patrick G.; Weldrick, Jonathan J.; Talab, Omar Mohamed Sayed Ahmed; Nadeer, Muhammad; Nomikos, Michail; ... more authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2023 , Article)
      Heart disease remains a global leading cause of death and disability, necessitating a comprehensive understanding of the heart’s development, repair, and dysfunction. This review surveys recent discoveries that explore the ...

    • STAC3-related myopathy: A Report of a Cohort of Seven Saudi Arabian Patients 

      Almomen, Momen; Amer, Fawzia; Alfaraj, Fatima; Burgon, Patrick G.; Bashir, Shahid; ... more authors ( Georg Thieme Verlag , 2024 , Article)
      Aim The study aims to review all the genetically confirmed STAC3-related myopathy being followed in a single center in the Eastern Province of Saudi Arabia. Methodology A retrospective review of all genetically confirmed ...

    • Why Craniofacial Surgeons/Researchers Need to be Aware of Native American Myopathy? 

      Almomen, Momen; Burgon, Patrick G. ( Georg Thieme Verlag , 2024 , Other)
      Congenital myopathy type 13 (CMYO13), also known as Native American myopathy, is a rare muscle disease characterized by early-onset hypotonia, muscle weakness, delayed motor milestones, and susceptibility to malignant ...