Browsing by Author "Maamoun, Hatem"
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Crosstalk Between Oxidative Stress and Endoplasmic Reticulum (ER) Stress in Endothelial Dysfunction and Aberrant Angiogenesis Associated With Diabetes: A Focus on the Protective Roles of Heme Oxygenase (HO)-1
Maamoun, Hatem; Benameur, Tarek; Pintus, Gianfranco; Munusamy, Shankar; Agouni, Abdelali ( Frontiers Media , 2019 , Article Review)Type-2 diabetes prevalence is continuing to rise worldwide due to physical inactivity and obesity epidemic. Diabetes and fluctuations of blood sugar are related to multiple micro- and macrovascular complications, that are ... -
Endoplasmic reticulum stress and oxidative stress drive endothelial dysfunction induced by high selenium
Zachariah, Matshediso; Maamoun, Hatem; Milano, Larissa; Rayman, Margaret P.; Meira, Lisiane B.; Agouni, Abdelali... more authors ... less authors ( Wiley , 2020 , Article)Selenium is an essential trace element important for human health. A balanced intake is, however, crucial to maximize the health benefits of selenium. At physiological concentrations, selenium mediates antioxidant, ... -
Endoplasmic Reticulum Stress: A Critical Molecular Driver of Endothelial Dysfunction and Cardiovascular Disturbances Associated with Diabetes.
Maamoun, Hatem; Abdelsalam, Shahenda S; Zeidan, Asad; Korashy, Hesham M; Agouni, Abdelali ( MDPI , 2019 , Article)Physical inactivity and sedentary lifestyle contribute to the widespread epidemic of obesity among both adults and children leading to rising cases of diabetes. Cardiovascular disease complications associated with obesity ... -
Heme oxygenase (HO)-1 induction prevents Endoplasmic Reticulum stress-mediated endothelial cell death and impaired angiogenic capacity
Maamoun, Hatem; Zachariah, Matshediso; McVey, John H.; Green, Fiona R.; Agouni, Abdelali ( Elsevier , 2016 , Article)Most of diabetic cardiovascular complications are attributed to endothelial dysfunction and impaired angiogenesis. Endoplasmic Reticulum (ER) and oxidative stresses were shown to play a pivotal role in the development of ... -
High Selenium Intake is Associated with Endothelial Dysfunction: Critical Role for Endoplasmic Reticulum Stress
Agouni, Abdelali; Zachariah, Matshediso; Maamoun, Hatem; Rayman, Margaret ( Hamad bin Khalifa University Press (HBKU Press) , 2016 , Conference Paper)Selenium is associated with insulin resistance and may therefore affect endothelial function, increasing type II diabetes risk and associated cardiovascular-disease risk. However the underpinning molecular mechanisms ...