Browsing by Author "Marei, Isra"
Now showing items 1-8 of 8
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Activation and Contraction of Human “Vascular” Smooth Muscle Cells Grown From Circulating Blood Progenitors
Ahmetaj-Shala, Blerina; Marei, Isra; Kawai, Ryota; Rothery, Stephen; Pericleous, Charis; Mohamed, Nura A.; Gashaw, Hime; Bokea, Kalliopi; Samuel, Jake; Vandenheste, Annabelle; Shala, Fisnik; Kirkby, Nicholas S.; Mitchell, Jane A.... more authors ... less authors ( Frontiers Media , 2021 , Article)Blood outgrowth smooth muscle cells (BO-SMCs) offer the means to study vascular cells without the requirement for surgery providing opportunities for drug discovery, tissue engineering, and personalized medicine. However, ... -
Assessment of Metal Organic Framework as Potential Drug Carriers in Cardiovascular Diseases
Al-Ansari, Dana E.; Mohamed, Nura A.; Marei, Isra; Yalcin, Huseyin; Abou-Saleh, Haissam ( Qatar University Press , 2020 , Poster)Background: Cardiovascular diseases (CVDs) are considered the major cause of death worldwide. Therapeutic delivery to the cardiovascular system may play an important role in the successful treatment of a variety of CVDs, ... -
Association of adiponectin gene polymorphism (+T45G) with acute coronary syndrome and circulating adiponectin levels
Rizk, Nasser M.; El-Menyar, Ayman; Marei, Isra; Sameer, Maha; Musad, Tasneem; Younis, Dima; Farag, Fathi; Basem, Nora; Al-Ali, Khalid; Suwaidi, Jassim Al... more authors ... less authors ( SAGE , 2012 , Article)We investigated the association of adiponectin gene polymorphisms (+T45G and +G276T) and adiponectin levels with acute coronary syndrome (ACS) among Arabs in Qatar. A case-control study was performed in 142 Arab patients ... -
Effect of Hyperglycemia on eNOS function in EPCs
Elshiekh, Duaa Ibnomer; Hendawi, Hadeel; Goul, Aya; Awartani, Dina; Marei, Isra; Triggle, Christopher; Abou Saleh, Haissam... more authors ... less authors ( Qatar University Press , 2020 , Poster)Type 2 diabetes mullites (T2DM) results in different cardiovascular complications. The main cause of these complications is endothelial dysfunction, which affects the endothelium physiologically and pathologically. The ... -
Effect of hyperglycemia on EPCs function and regenerative ability
Hendawi, Hadeel Khalil; Awartani, Dina Nehad; Ghoul, Aya; Marei, Isra; Abou Saleh, Haissam; Triggle, Christopher... more authors ... less authors ( Qatar University Press , 2020 , Poster)Diabetes induced hyperglycemia increases the risk of cardiovascular complications as it impacts vascular endothelial cells causing vascular dysfunction. Endothelial progenitor cells (EPCs) have been suggested to participate ... -
Internalization of metal-organic framework nanoparticles in human vascular cells: Implications for cardiovascular disease therapy
Al-Ansari, Dana E.; Mohamed, Nura A.; Marei, Isra; Zekri, Atef; Kameno, Yu; Davies, Robert P.; Lickiss, Paul D.; Rahman, Md Mizanur; Abou-Saleh, Haissam... more authors ... less authors ( Multidisciplinary Digital Publishing Institute (MDPI) , 2020 , Article)Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide. Alteration of endothelial cells and the underlying vasculature plays a central role in the pathogenesis of various CVDs. The ... -
Recent Developments in Nanomaterials-Based Drug Delivery and Upgrading Treatment of Cardiovascular Diseases
Mohamed, Nura A.; Marei, Isra; Crovella, Sergio; Abou-Saleh, Haissam ( MDPI , 2022 , Article)Cardiovascular diseases (CVDs) are the leading causes of morbidity and mortality worldwide. However, despite the recent developments in the management of CVDs, the early and long outcomes vary considerably in patients, ... -
Studies on metal–organic framework (MOF) nanomedicine preparations of sildenafil for the future treatment of pulmonary arterial hypertension
Mohamed, Nura A.; Abou-Saleh, Haissam; Kameno, Yu; Marei, Isra; de Nucci, Gilberto; Ahmetaj-Shala, Blerina; Shala, Fisnik; Kirkby, Nicholas S.; Jennings, Lewis; Al-Ansari, Dana E.; Davies, Robert P.; Lickiss, Paul D.; Mitchell, Jane A.... more authors ... less authors ( nature , 2021 , Article)Pulmonary arterial hypertension (PAH) is an incurable disease, although symptoms are treated with a range of dilator drugs. Despite their clinical benefits, these drugs are limited by systemic side-effects. It is, therefore, ...