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Can atorvastatin with metformin change the natural history of prostate cancer as characterized by molecular, metabolomic, imaging and pathological variables? A randomized controlled trial protocol

Roberts, Matthew J.; Yaxley, John W.; Coughlin, Geoffrey D.; Gianduzzo, Troy R.J.; Esler, Rachel C.; Dunglison, Nigel T.; Chambers, Suzanne K.; Medcraft, Robyn J.; Chow, Clement W.K.; Schirra, Horst Joachim; Richards, Renee S.; Kienzle, Nicholas; Lu, Macy; Brereton, Ian; Samaratunga, Hema; Perry-Keene, Joanna; Payton, Diane; Oyama, Chikara; Doi, Suhail A.; Lavin, Martin F.; Gardiner, Robert A.... more authors ... less authors ( Elsevier , 2016 , Article)
Background Atorvastatin and metformin are known energy restricting mimetic agents that act synergistically to produce molecular and metabolic changes in advanced prostate cancer (PCa). This trial seeks to determine whether ...