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المؤلفSmith E.
المؤلفZhou W.
المؤلفShindiapina P.
المؤلفSif S.
المؤلفLi C.
المؤلفBaiocchi R.A.
تاريخ الإتاحة2019-09-25T11:18:31Z
تاريخ النشر2018
اسم المنشورExpert Opinion on Therapeutic Targets
المصدرScopus
الرقم المعياري الدولي للكتاب14728222
معرّف المصادر الموحدhttp://dx.doi.org/10.1080/14728222.2018.1474203
معرّف المصادر الموحدhttp://hdl.handle.net/10576/11944
الملخصIntroduction: Exploration in the field of epigenetics has revealed the diverse roles of the protein arginine methyltransferase (PRMT) family of proteins in multiple disease states. These findings have led to the development of specific inhibitors and discovery of several new classes of drugs with potential to treat both benign and malignant conditions. Areas covered: We provide an overview on the role of PRMT enzymes in healthy and malignant cells, highlighting the role of arginine methylation in specific pathways relevant to cancer pathogenesis. Additionally, we describe structure and catalytic activity of PRMT and discuss the mechanisms of action of novel small molecule inhibitors of specific members of the arginine methyltransferase family. Expert opinion: As the field of PRMT biology advances, it’s becoming clear that this class of enzymes is highly relevant to maintaining normal physiologic processes as well and disease pathogenesis. We discuss the potential impact of PRMT inhibitors as a broad class of drugs, including the pleiotropic effects, off target effects the need for more detailed PRMT-centric interactomes, and finally, the potential for targeting this class of enzymes in clinical development of experimental therapeutics for cancer. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
راعي المشروعThe study was funded by the Qatar National Research Fund (QNRF) through the National Priorities Research Program (NPRP) grant [NPRP8-617-3-131].
اللغةen
الناشرTaylor and Francis Ltd
الموضوعarginine-methylation
Cancer
epigenetics
therapeutic target
العنوانRecent advances in targeting protein arginine methyltransferase enzymes in cancer therapy
النوعArticle Review
الصفحات527-545
رقم العدد6
رقم المجلد22
dc.accessType Open Access


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