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المؤلفAli M.H.M.
المؤلفRakib F.
المؤلفNischwitz V.
المؤلفUllah E.
المؤلفMall R.
المؤلفShraim A.M.
المؤلفAhmad M.I.
المؤلفGhouri Z.K.
المؤلفMcNaughton D.
المؤلفKuppers S.
المؤلفAhmed T.
المؤلفAl-Saad K.
تاريخ الإتاحة2019-11-03T11:47:37Z
تاريخ النشر2018
اسم المنشورApplied Sciences (Switzerland)
المصدرScopus
الرقم المعياري الدولي للكتاب20763417
معرّف المصادر الموحدhttp://dx.doi.org/10.3390/app8122436
معرّف المصادر الموحدhttp://hdl.handle.net/10576/12210
الملخصFourier Transform Infrared Spectroscopy (FTIR) is a non-destructive analytical technique that has been employed in this research to characterize the biochemical make-up of various rat brain regions. The sensorimotor cortex, caudate putamen, thalamus, and the hippocampus were found to have higher olefinic content-an indicator of a higher degree of unsaturated fatty acids-rich in short-chain fatty acids, and low in ester and lipid contents. While the regions of the corpus callosum, internal, and external capsule were found to contain long-chained and higher-esterified saturated fatty acids. These molecular differences may reflect the roles of the specific regions in information processing and can provide a unique biochemical platform for future studies on the earlier detection of pathology development in the brain, as a consequence of disease or injury. Laser Ablation Inductively Coupled Plasma Mass Spectroscopy (LA-ICP-MS) is another vital analytical technique that was used in this work to analyze the elements' distribution patterns in various regions of the brain. The complementary data sets allowed the characterization of the brain regions, the chemical dominating groups, and the elemental composition. This set-up may be used for the investigation of changes in the brain caused by diseases and help create a deeper understanding of the interactions between the organic and elemental composition.
راعي المشروعQatar Biomedical Research Institute (QBRI), Hamad Bin Khalifa University (HBKU), Doha 34110, Qatar; taahmed@qf.org.qa Department of Chemistry and Earth Sciences, Qatar University, Doha 2713, Qatar; fazle@qu.edu.qa (F.R.); amjad@qu.edu.qa (A.M.S.); kalsaad@qu.edu.qa (K.A.-S.) Forschungszentrum J�lich GmbH, Zentralinstitut f�r Engineering, 52425 Elektronik und Analytik, Germany; v.nischwitz@fz-juelich.de (V.N.); s.kueppers@fz-juelich.de (S.K.) Qatar Computing Research Institute (QCRI), Hamad Bin Khalifa University, Doha 34110, Qatar; eullah@hbku.edu.qa (E.U.); rmall@hbku.edu.qa (R.M.) Central Laboratories Unit, Qatar University, Doha 2713, Qatar; mohammad.ibrahim@qu.edu.qa Chemical Engineering Program, Texas A&M University at Qatar, Doha 23874, Qatar; zafarkhanghouri@hotmail.com Centre for Biospectroscopy and the School of Chemistry, Monash University, Clayton, Victoria 3800, Australia; donald.mcnaughton@monash.edu Correspondence: mohamali@hbku.edu.qa
اللغةen
الناشرMDPI AG
الموضوعBiochemical analysis
Brain
FTIR imaging spectroscopy
LA-ICP-MS
العنوانApplication of FTIR and LA-ICPMS spectroscopies as a possible approach for biochemical analyses of different rat brain regions
النوعArticle
رقم العدد12
رقم المجلد8
dc.accessType Abstract Only


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